Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability

The Psychiatric Genomics Consortium-Posttraumatic Stress Disorder group (PGC-PTSD) combined genome-wide case-control molecular genetic data across 11 multiethnic studies to quantify PTSD heritability, to examine potential shared genetic risk with schizophrenia, bipolar disorder, and major depressive...

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Vydáno v:	Molecular psychiatry Ročník 23; číslo 3; s. 666
Hlavní autoři:	Duncan, L E, Ratanatharathorn, A, Aiello, A E, Almli, L M, Amstadter, A B, Ashley-Koch, A E, Baker, D G, Beckham, J C, Bierut, L J, Bisson, J, Bradley, B, Chen, C-Y, Dalvie, S, Farrer, L A, Galea, S, Garrett, M E, Gelernter, J E, Guffanti, G, Hauser, M A, Johnson, E O, Kessler, R C, Kimbrel, N A, King, A, Koen, N, Kranzler, H R, Logue, M W, Maihofer, A X, Martin, A R, Miller, M W, Morey, R A, Nugent, N R, Rice, J P, Ripke, S, Roberts, A L, Saccone, N L, Smoller, J W, Stein, D J, Stein, M B, Sumner, J A, Uddin, M, Ursano, R J, Wildman, D E, Yehuda, R, Zhao, H, Daly, M J, Liberzon, I, Ressler, K J, Nievergelt, C M, Koenen, K C
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Nature Publishing Group 01.03.2018
Témata:	Adult Bipolar disorder Bipolar Disorder - genetics Black or African American - genetics Case-Control Studies Depressive Disorder, Major - genetics Female Genetic disorders Genetic diversity Genetic Predisposition to Disease - genetics Genome-Wide Association Study Genomes Heritability Humans Male Mental depression Mental disorders Middle Aged Multifactorial Inheritance - genetics Polymorphism, Single Nucleotide Post traumatic stress disorder Risk Factors Schizophrenia Schizophrenia - genetics Sex Characteristics Sex differences Sex Factors Single-nucleotide polymorphism Statistical analysis Stress Disorders, Post-Traumatic - genetics Systematic review White People - genetics
ISSN:	1359-4184, 1476-5578, 1476-5578
On-line přístup:	Získat plný text
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