Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

Molecular alterations in KRAS are associated with acquired resistance to anti-epidermal growth factor receptor (EGFR) treatment in colorectal cancer; resistant mutations can be identified in the blood of patients, months before clinical evidence of disease progression. Acquired resistance in anti-EG...

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Published in:	Nature (London) Vol. 486; no. 7404; pp. 532 - 536
Main Authors:	Misale, Sandra, Yaeger, Rona, Hobor, Sebastijan, Scala, Elisa, Janakiraman, Manickam, Liska, David, Valtorta, Emanuele, Schiavo, Roberta, Buscarino, Michela, Siravegna, Giulia, Bencardino, Katia, Cercek, Andrea, Chen, Chin-Tung, Veronese, Silvio, Zanon, Carlo, Sartore-Bianchi, Andrea, Gambacorta, Marcello, Gallicchio, Margherita, Vakiani, Efsevia, Boscaro, Valentina, Medico, Enzo, Weiser, Martin, Siena, Salvatore, Di Nicolantonio, Federica, Solit, David, Bardelli, Alberto
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 28.06.2012 Nature Publishing Group
Subjects:	631/208/68 631/67/1059/2326 631/67/1504/1885 Alleles Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Antineoplastic agents Biological and medical sciences Cancer therapies Cell Line, Tumor Cetuximab Cloning Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Disease Progression Drug resistance Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics ErbB Receptors - antagonists & inhibitors Experiments Gastroenterology. Liver. Pancreas. Abdomen Genes, ras - genetics Humanities and Social Sciences Humans Immunotherapy Kinases letter Mass spectrometry Medical sciences Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors multidisciplinary Mutation Mutation - genetics Panitumumab Pharmacology. Drug treatments Promoter Regions, Genetic - genetics Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins p21(ras) ras Proteins - genetics Science Science (multidisciplinary) Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors Antineoplastic agent Human Treatment resistance Rectal disease Colorectal cancer Monoclonal antibody Malignant tumor Epidermal growth factor receptor Colonic disease K ras Gene Cancerology Treatment C-Onc gene Immunotherapy Genetics Digestive diseases Intestinal disease Mutation Cetuximab Protooncogene Cancer
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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