A nuclear F-actin scaffold stabilizes ribonucleoprotein droplets against gravity in large cells

Actin is abundant in the nuclei of oocytes but its role has been unclear. Feric and Brangwynne find that actin forms a network that prevents the sedimentation of RNA and protein bodies caused by gravitational forces. The size of a typical eukaryotic cell is of the order of ∼10 μm. However, some cell...

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Vydáno v:	Nature cell biology Ročník 15; číslo 10; s. 1253 - 1259
Hlavní autoři:	Feric, Marina, Brangwynne, Clifford P.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 01.10.2013 Nature Publishing Group
Témata:	631/136/2434/1706 631/80/128/1276 Actin Actins - metabolism Amphibians Animals Brownian motion Cancer Research Cell Biology Cell Nucleus - metabolism Cell Size Cells Developmental Biology Eggs Female Gravitation Humans letter Life Sciences Microscopy, Confocal Models, Biological Nuclear Matrix - metabolism Oocytes - cytology Oocytes - growth & development Oocytes - metabolism Physiological aspects Ribonucleoproteins Ribonucleoproteins - metabolism Stem Cells Xenopus - metabolism United States
ISSN:	1465-7392, 1476-4679, 1476-4679
On-line přístup:	Získat plný text
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