Cardiac arrhythmia induced by genetic silencing of ‘funny’ (f) channels is rescued by GIRK4 inactivation

The mechanisms underlying cardiac automaticity are still incompletely understood and controversial. Here we report the complete conditional and time-controlled silencing of the ‘funny’ current ( I f ) by expression of a dominant-negative, non-conductive HCN4-channel subunit (hHCN4-AYA). Heart-specif...

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Veröffentlicht in:	Nature communications Jg. 5; H. 1; S. 4664
Hauptverfasser:	Mesirca, Pietro, Alig, Jacqueline, Torrente, Angelo G., Müller, Jana Christina, Marger, Laurine, Rollin, Anne, Marquilly, Claire, Vincent, Anne, Dubel, Stefan, Bidaud, Isabelle, Fernandez, Anne, Seniuk, Anika, Engeland, Birgit, Singh, Jasmin, Miquerol, Lucile, Ehmke, Heimo, Eschenhagen, Thomas, Nargeot, Joel, Wickman, Kevin, Isbrandt, Dirk, Mangoni, Matteo E.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 21.08.2014 Nature Publishing Group
Schlagworte:	14/32 14/34 42/41 631/208/2489/144 631/208/2489/201 631/443/592/75/29 9/74 Animals Arrhythmias, Cardiac - drug therapy Arrhythmias, Cardiac - genetics Arrhythmias, Cardiac - physiopathology Benzazepines - pharmacology Calcium Signaling - genetics Cardiology and cardiovascular system Disease Models, Animal Female G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism Genetics Heart Rate - drug effects Human health and pathology Humanities and Social Sciences Humans Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - genetics Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism Inactivation Life Sciences Male Mice Mice, Inbred C57BL Mice, Transgenic multidisciplinary Muscle Proteins - genetics Muscle Proteins - metabolism Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Oocytes - physiology Patch-Clamp Techniques Potassium Channels - genetics Potassium Channels - metabolism Pregnancy Science Science (multidisciplinary) Xenopus Gene therapy Arrhythmias Disease genetics
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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