Inhibitory suppression of heterogeneously tuned excitation enhances spatial coding in CA1 place cells

The authors investigate the role of inhibition in shaping spatial selectivity of CA1 place cells. Combining whole-cell recordings, optogenetics and computational modeling, they demonstrate that inhibition enhances both rate and temporal coding of space by counteracting noise from broad out-of-field...

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Bibliographic Details
Published in:	Nature neuroscience Vol. 20; no. 3; pp. 417 - 426
Main Authors:	Grienberger, Christine, Milstein, Aaron D, Bittner, Katie C, Romani, Sandro, Magee, Jeffrey C
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.03.2017 Nature Publishing Group
Subjects:	631/378/116/2392 631/378/1595/1554 631/378/2629/2630 631/378/3920 64 64/60 9/74 Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedicine CA1 Region, Hippocampal - physiology Electrophysiology Female Hippocampus (Brain) Interneurons - physiology Locomotion - physiology Male Membrane Potentials - physiology Mice Models, Neurological Neural Inhibition - physiology Neurobiology Neurosciences Place Cells - physiology Pyramidal Cells - physiology United States
ISSN:	1097-6256, 1546-1726
Online Access:	Get full text
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