STING protects breast cancer cells from intrinsic and genotoxic-induced DNA instability via a non-canonical, cell-autonomous pathway

STING (Stimulator of Interferon Genes) is an endoplasmic reticulum-anchored adaptor of the innate immunity best known to trigger pro-inflammatory cytokine expression in response to pathogen infection. In cancer, this canonical pathway can be activated by intrinsic or drug-induced genomic instability...

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Bibliographic Details
Published in:	Oncogene Vol. 40; no. 49; pp. 6627 - 6640
Main Authors:	Cheradame, Laura, Guerrera, Ida Chiara, Gaston, Julie, Schmitt, Alain, Jung, Vincent, Goudin, Nicolas, Pouillard, Marion, Radosevic-Robin, Nina, Modesti, Mauro, Judde, Jean-Gabriel, Cairo, Stefano, Goffin, Vincent
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 09.12.2021 Nature Publishing Group Nature Publishing Group [1987-....]
Subjects:	13/51 13/89 14/1 14/28 631/337/1427 631/67/1347 631/80/2373 82/29 82/58 96/109 96/21 Animals Antitumor activity Apoptosis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Breast Neoplasms - prevention & control Cancer Cancer cells Cell Biology Cell culture Cell Proliferation Cell survival Chemotherapy Deoxyribonucleic acid Development and progression DNA DNA Damage DNA-dependent protein kinase Endoplasmic reticulum Female Gene Expression Regulation, Neoplastic Genetic aspects Genomic Instability Genotoxicity Health aspects Human Genetics Humans Immune response Immunosurveillance Inflammation Innate immunity Interferon Internal Medicine Life Sciences Medicine Medicine & Public Health Membrane proteins Membrane Proteins - genetics Membrane Proteins - metabolism Mice Microsatellite instability Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - prevention & control Nucleotidyltransferases - genetics Nucleotidyltransferases - metabolism Oncology Oncology, Experimental Ovarian cancer Prognosis Survival Rate Tumor cell lines Tumor Cells, Cultured Tumors Xenograft Model Antitumor Assays France Cellular imaging Breast cancer DNA damage and repair
ISSN:	0950-9232, 1476-5594, 1476-5594
Online Access:	Get full text
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