HULC: an oncogenic long non‐coding RNA in human cancer
Highly up‐regulated in liver cancer (HULC) was originally identified as the most overexpressed long non‐coding RNA in hepatocellular carcinoma. Since its discovery, the aberrant up‐regulation of HULC has been demonstrated in other cancer types, including gastric cancer, pancreatic cancer, osteosarco...
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| Published in: | Journal of cellular and molecular medicine Vol. 21; no. 2; pp. 410 - 417 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
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England
John Wiley & Sons, Inc
01.02.2017
John Wiley and Sons Inc |
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| ISSN: | 1582-1838, 1582-4934, 1582-4934 |
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| Abstract | Highly up‐regulated in liver cancer (HULC) was originally identified as the most overexpressed long non‐coding RNA in hepatocellular carcinoma. Since its discovery, the aberrant up‐regulation of HULC has been demonstrated in other cancer types, including gastric cancer, pancreatic cancer, osteosarcoma and hepatic metastasis of colorectal cancer. Recent discoveries have also shed new light on the upstream molecular mechanisms underlying HULC deregulation. As an oncogene, HULC promotes tumorigenesis by regulating multiple pathways, such as down‐regulation of EEF1E1, promotion of abnormal lipid metabolism, and up‐regulation of sphingosine kinase 1. Pertinent to clinical practice, a genetic variant in the HULC gene has been found to alter the risk for hepatocellular carcinoma and oesophageal cancer, whereas cancer patients with high or low expression of HULC exhibit different clinical outcome. These findings highlighted the pathogenic role and clinical utility of HULC in human cancers. Further efforts are warranted to promote the development of HULC‐directed therapeutics. |
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| AbstractList | Highly up‐regulated in liver cancer (HULC) was originally identified as the most overexpressed long non‐coding RNA in hepatocellular carcinoma. Since its discovery, the aberrant up‐regulation of HULC has been demonstrated in other cancer types, including gastric cancer, pancreatic cancer, osteosarcoma and hepatic metastasis of colorectal cancer. Recent discoveries have also shed new light on the upstream molecular mechanisms underlying HULC deregulation. As an oncogene, HULC promotes tumorigenesis by regulating multiple pathways, such as down‐regulation of EEF1E1, promotion of abnormal lipid metabolism, and up‐regulation of sphingosine kinase 1. Pertinent to clinical practice, a genetic variant in the HULC gene has been found to alter the risk for hepatocellular carcinoma and oesophageal cancer, whereas cancer patients with high or low expression of HULC exhibit different clinical outcome. These findings highlighted the pathogenic role and clinical utility of HULC in human cancers. Further efforts are warranted to promote the development of HULC‐directed therapeutics. Highly up-regulated in liver cancer (HULC) was originally identified as the most overexpressed long non-coding RNA in hepatocellular carcinoma. Since its discovery, the aberrant up-regulation of HULC has been demonstrated in other cancer types, including gastric cancer, pancreatic cancer, osteosarcoma and hepatic metastasis of colorectal cancer. Recent discoveries have also shed new light on the upstream molecular mechanisms underlying HULC deregulation. As an oncogene, HULC promotes tumorigenesis by regulating multiple pathways, such as down-regulation of EEF1E1, promotion of abnormal lipid metabolism, and up-regulation of sphingosine kinase 1. Pertinent to clinical practice, a genetic variant in the HULC gene has been found to alter the risk for hepatocellular carcinoma and oesophageal cancer, whereas cancer patients with high or low expression of HULC exhibit different clinical outcome. These findings highlighted the pathogenic role and clinical utility of HULC in human cancers. Further efforts are warranted to promote the development of HULC-directed therapeutics.Highly up-regulated in liver cancer (HULC) was originally identified as the most overexpressed long non-coding RNA in hepatocellular carcinoma. Since its discovery, the aberrant up-regulation of HULC has been demonstrated in other cancer types, including gastric cancer, pancreatic cancer, osteosarcoma and hepatic metastasis of colorectal cancer. Recent discoveries have also shed new light on the upstream molecular mechanisms underlying HULC deregulation. As an oncogene, HULC promotes tumorigenesis by regulating multiple pathways, such as down-regulation of EEF1E1, promotion of abnormal lipid metabolism, and up-regulation of sphingosine kinase 1. Pertinent to clinical practice, a genetic variant in the HULC gene has been found to alter the risk for hepatocellular carcinoma and oesophageal cancer, whereas cancer patients with high or low expression of HULC exhibit different clinical outcome. These findings highlighted the pathogenic role and clinical utility of HULC in human cancers. Further efforts are warranted to promote the development of HULC-directed therapeutics. Highly up‐regulated in liver cancer ( HULC ) was originally identified as the most overexpressed long non‐coding RNA in hepatocellular carcinoma. Since its discovery, the aberrant up‐regulation of HULC has been demonstrated in other cancer types, including gastric cancer, pancreatic cancer, osteosarcoma and hepatic metastasis of colorectal cancer. Recent discoveries have also shed new light on the upstream molecular mechanisms underlying HULC deregulation. As an oncogene, HULC promotes tumorigenesis by regulating multiple pathways, such as down‐regulation of EEF 1E1, promotion of abnormal lipid metabolism, and up‐regulation of sphingosine kinase 1. Pertinent to clinical practice, a genetic variant in the HULC gene has been found to alter the risk for hepatocellular carcinoma and oesophageal cancer, whereas cancer patients with high or low expression of HULC exhibit different clinical outcome. These findings highlighted the pathogenic role and clinical utility of HULC in human cancers. Further efforts are warranted to promote the development of HULC ‐directed therapeutics. |
| Author | Yu, Xin Wu, William Ka Kei Zheng, Heyi Chan, Matthew T.V. |
| AuthorAffiliation | 3 State Key Laboratory of Digestive Disease LKS Institute of Health Sciences The Chinese University of Hong Kong Hong Kong China 1 Department of Dermatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China 2 Department of Anaesthesia and Intensive Care The Chinese University of Hong Kong Hong Kong China |
| AuthorAffiliation_xml | – name: 2 Department of Anaesthesia and Intensive Care The Chinese University of Hong Kong Hong Kong China – name: 1 Department of Dermatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China – name: 3 State Key Laboratory of Digestive Disease LKS Institute of Health Sciences The Chinese University of Hong Kong Hong Kong China |
| Author_xml | – sequence: 1 givenname: Xin surname: Yu fullname: Yu, Xin organization: Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 2 givenname: Heyi surname: Zheng fullname: Zheng, Heyi email: Zhenghy62@sina.com organization: Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 3 givenname: Matthew T.V. surname: Chan fullname: Chan, Matthew T.V. organization: The Chinese University of Hong Kong – sequence: 4 givenname: William Ka Kei surname: Wu fullname: Wu, William Ka Kei organization: The Chinese University of Hong Kong |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27781386$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1155/2013/136106 10.1371/journal.pone.0035145 10.1158/0008-5472.CAN-14-1192 10.1038/cddis.2015.203 10.1053/j.gastro.2006.08.026 10.1158/0008-5472.CAN-14-0686 10.1158/0008-5472.CAN-11-1021 10.1053/j.gastro.2009.08.005 10.1002/mc.20627 10.1038/sj.onc.1209091 10.1177/030089161109700321 10.1002/mc.20446 10.1093/hmg/ddl046 10.1159/000430387 10.1038/nsmb.3005 10.1038/onc.2012.193 10.1038/mt.2015.166 10.1016/j.neo.2014.11.004 10.1002/ijc.29022 10.5009/gnl13392 10.1186/s13045-015-0153-1 10.1186/s12885-015-1214-0 10.1038/nature11247 10.1016/B978-0-12-394274-6.00007-8 10.1016/j.cmet.2012.08.010 10.1093/nar/gkq285 10.1016/j.intimp.2015.04.028 10.1097/MEG.0b013e328306a3a2 10.1038/nature11508 10.1016/j.autrev.2015.05.004 10.1007/s12032-014-0346-4 10.1155/2015/191029 10.18632/oncotarget.4560 10.1038/mt.2015.170 10.3892/or.2013.2850 10.2174/15680096113136660102 10.1016/j.chom.2014.10.001 10.1007/s13277-015-3328-z 10.1158/0008-5472.CAN-05-3740 10.1016/j.prp.2013.07.010 10.1038/nature02538 10.1261/rna.037598.112 10.18632/oncotarget.6280 10.2174/1871520615666150716105955 10.1074/jbc.M112.342113 10.1155/2013/251098 10.1016/j.molcel.2013.08.027 10.1002/hep.26537 |
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| Copyright | 2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. 2017. This work is published under https://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| Keywords | cancer long non-coding RNAs oncogene prognosis HULC |
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| References | 2015; 15 2015; 37 2015; 14 2015; 36 2015; 6 2010; 38 2015; 17 2012; 287 2009; 21 2013; 209 2015; 75 2006; 15 2011; 97 2012; 16 2012; 489 2015; 8 2016; 16 2015; 7 2009; 137 2005; 24 2004; 429 2013; 19 2012; 491 2015; 23 2015; 28 2010; 49 2013; 58 2013; 32 2013; 2013 2013; 13 2006; 66 2015; 136 2011; 71 2007; 132 2015; 22 2013; 52 2013; 117 2014; 16 2008; 47 2015; 2015 2014; 74 2014; 8 2012; 7 2014; 31 e_1_2_8_28_1 e_1_2_8_24_1 e_1_2_8_47_1 e_1_2_8_26_1 e_1_2_8_49_1 e_1_2_8_3_1 e_1_2_8_5_1 Hua L (e_1_2_8_18_1) 2015; 8 e_1_2_8_7_1 e_1_2_8_9_1 e_1_2_8_20_1 e_1_2_8_43_1 e_1_2_8_22_1 e_1_2_8_45_1 e_1_2_8_41_1 e_1_2_8_17_1 e_1_2_8_19_1 e_1_2_8_13_1 e_1_2_8_36_1 e_1_2_8_15_1 e_1_2_8_38_1 e_1_2_8_32_1 e_1_2_8_11_1 e_1_2_8_34_1 e_1_2_8_51_1 e_1_2_8_30_1 e_1_2_8_29_1 e_1_2_8_25_1 e_1_2_8_46_1 e_1_2_8_27_1 e_1_2_8_48_1 e_1_2_8_2_1 e_1_2_8_4_1 e_1_2_8_6_1 e_1_2_8_8_1 e_1_2_8_21_1 e_1_2_8_44_1 e_1_2_8_40_1 e_1_2_8_39_1 e_1_2_8_14_1 e_1_2_8_35_1 e_1_2_8_16_1 e_1_2_8_37_1 Zhang Y (e_1_2_8_42_1) 2015; 8 e_1_2_8_10_1 e_1_2_8_31_1 e_1_2_8_12_1 Sun XH (e_1_2_8_23_1) 2015; 8 e_1_2_8_33_1 e_1_2_8_52_1 e_1_2_8_50_1 25592151 - Cancer Res. 2015 Mar 1;75(5):846-57 24054033 - Pathol Res Pract. 2013 Nov;209(11):700-4 24917520 - Int J Cancer. 2015 Feb 1;136(3):709-20 26540633 - Oncotarget. 2016 Jan 5;7(1):241-54 25966845 - J Hematol Oncol. 2015 May 14;8:50 24055342 - Mol Cell. 2013 Oct 10;52(1):101-12 20423907 - Nucleic Acids Res. 2010 Sep;38(16):5366-83 25880458 - BMC Cancer. 2015 Mar 26;15:182 26291312 - Cell Death Dis. 2015 Aug 20;6:e1858 16288291 - Oncogene. 2005 Nov 14;24(50):7443-54 17241883 - Gastroenterology. 2007 Jan;132(1):330-42 20232364 - Mol Carcinog. 2010 May;49(5):476-87 26356260 - Cell Physiol Biochem. 2015;37(2):687-96 25412939 - Med Oncol. 2014 Dec;31(12):346 23728852 - Hepatology. 2013 Nov;58(5):1703-12 23064229 - Nature. 2012 Nov 15;491(7424):454-7 24168186 - Curr Cancer Drug Targets. 2013 Nov;13(9):963-72 23040067 - Cell Metab. 2012 Oct 3;16(4):435-48 25277524 - Cancer Res. 2014 Dec 1;74(23):6890-902 15175754 - Nature. 2004 Jun 3;429(6991):571-4 23762823 - Biomed Res Int. 2013;2013:136106 25622901 - Neoplasia. 2015 Jan;17(1):79-88 16849534 - Cancer Res. 2006 Jul 15;66(14):6913-8 21862635 - Cancer Res. 2011 Oct 15;71(20):6320-6 16651366 - Hum Mol Genet. 2006 Apr 15;15 Spec No 1:R17-29 22614017 - Oncogene. 2013 Mar 28;32(13):1616-25 26179263 - Anticancer Agents Med Chem. 2016;16(4):414-23 26136615 - Dis Markers. 2015;2015:191029 19445043 - Eur J Gastroenterol Hepatol. 2009 Jun;21(6):688-92 26045809 - Int J Clin Exp Pathol. 2015 Mar 01;8(3):2994-3000 22685290 - J Biol Chem. 2012 Jul 27;287(31):26302-11 26347501 - Mol Ther. 2015 Dec;23 (12 ):1843-53 22493738 - PLoS One. 2012;7(4):e35145 23431328 - RNA. 2013 Apr;19(4):429-42 26550214 - Int J Clin Exp Med. 2015 Aug 15;8(8):12956-62 21789020 - Tumori. 2011 May-Jun;97(3):380-5 25368754 - Gut Liver. 2014 Nov;8(6):662-8 25952928 - Int Immunopharmacol. 2015 Oct;28(2):901-5 18444243 - Mol Carcinog. 2008 Dec;47(12):925-33 23862139 - Biomed Res Int. 2013;2013:251098 25874495 - Tumour Biol. 2015 Aug;36(8):6401-8 24247585 - Oncol Rep. 2014 Jan;31(1):358-64 25989481 - Autoimmun Rev. 2015 Sep;14(9):798-805 26370254 - Mol Ther. 2015 Dec;23 (12 ):1899-911 25525793 - Cell Host Microbe. 2014 Nov 12;16(5):616-26 26317792 - Oncotarget. 2015 Sep 22;6(28):26359-72 22955616 - Nature. 2012 Sep 6;489(7414):57-74 19686743 - Gastroenterology. 2009 Nov;137(5):1816-26.e1-10 25849144 - Nat Struct Mol Biol. 2015 May;22(5):370-6 26045820 - Int J Clin Exp Pathol. 2015 Mar 01;8(3):3076-82 23290781 - Adv Cancer Res. 2013;117:201-35 |
| References_xml | – volume: 23 start-page: 1899 year: 2015 end-page: 911 article-title: Gas5 exerts tumor‐suppressive functions in human glioma cells by targeting miR‐222 publication-title: Mol Ther – volume: 14 start-page: 798 year: 2015 end-page: 805 article-title: Emerging role of long noncoding RNAs in autoimmune diseases publication-title: Autoimmun Rev – volume: 32 start-page: 1616 year: 2013 end-page: 25 article-title: HOTAIR is a negative prognostic factor and exhibits pro‐oncogenic activity in pancreatic cancer publication-title: Oncogene – volume: 7 start-page: e35145 year: 2012 article-title: A genetic variant in long non‐coding RNA HULC contributes to risk of HBV‐related hepatocellular carcinoma in a Chinese population publication-title: PLoS ONE – volume: 28 start-page: 901 year: 2015 end-page: 5 article-title: LncRNA HULC affects the differentiation of Treg in HBV‐related liver cirrhosis publication-title: Int Immunopharmacol – volume: 66 start-page: 6913 year: 2006 end-page: 8 article-title: AIMP3 haploinsufficiency disrupts oncogene‐induced p53 activation and genomic stability publication-title: Cancer Res – volume: 13 start-page: 963 year: 2013 end-page: 72 article-title: the role of snail in EMT and tumorigenesis publication-title: Curr Cancer Drug Targets – volume: 132 start-page: 330 year: 2007 end-page: 42 article-title: Characterization of HULC, a novel gene with striking up‐regulation in hepatocellular carcinoma, as noncoding RNA publication-title: Gastroenterology – volume: 16 start-page: 414 year: 2016 end-page: 23 article-title: miR‐203 suppresses the proliferation and metastasis of hepatocellular carcinoma by targeting oncogene ADAM9 and oncogenic long non‐coding RNA HULC publication-title: Anti‐Cancer Agents Med Chem – volume: 8 start-page: 3076 year: 2015 end-page: 82 article-title: High expression of long non‐coding RNA ANRIL is associated with poor prognosis in hepatocellular carcinoma publication-title: Int J Clin Exp Pathol – volume: 7 start-page: 241 year: 2015 end-page: 54 article-title: Long non‐coding RNA HULC promotes tumor angiogenesis in liver cancer by up‐regulating sphingosine kinase 1 (SPHK1) publication-title: Oncotarget – volume: 52 start-page: 101 year: 2013 end-page: 12 article-title: The imprinted H19 lncRNA antagonizes let‐7 microRNAs publication-title: Mol Cell – volume: 8 start-page: 662 year: 2014 end-page: 8 article-title: High expression of ribonucleotide reductase subunit M2 correlates with poor prognosis of hepatocellular carcinoma publication-title: Gut Liv – volume: 8 start-page: 12956 year: 2015 end-page: 62 article-title: Molecular mechanism of HEIH and HULC in the proliferation and invasion of hepatoma cells publication-title: Int J Clin Exp Med – volume: 19 start-page: 429 year: 2013 end-page: 42 article-title: Noncoding RNA and Polycomb recruitment publication-title: RNA – volume: 15 start-page: R17 year: 2006 end-page: 29 article-title: Non‐coding RNA publication-title: Human Mol Genet – volume: 209 start-page: 700 year: 2013 end-page: 4 article-title: Downregulation of GLTSCR2 expression is correlated with breast cancer progression publication-title: Pathol Res Pract – volume: 6 start-page: e1858 year: 2015 article-title: A novel lncRNA, LUADT1, promotes lung adenocarcinoma proliferation the epigenetic suppression of p27 publication-title: Cell Death Dis – volume: 489 start-page: 57 year: 2012 end-page: 74 article-title: An integrated encyclopedia of DNA elements in the human genome publication-title: Nature – volume: 491 start-page: 454 year: 2012 end-page: 7 article-title: Long non‐coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat publication-title: Nature – volume: 49 start-page: 476 year: 2010 end-page: 87 article-title: Stathmin1 overexpression associated with polyploidy, tumor‐cell invasion, early recurrence, and poor prognosis in human hepatoma publication-title: Mol Carcinog – volume: 2013 start-page: 251098 year: 2013 article-title: Long noncoding RNA HOTAIR is associated with motility, invasion, and metastatic potential of metastatic melanoma publication-title: BioMed Res Int – volume: 37 start-page: 687 year: 2015 end-page: 96 article-title: HULC and Linc00152 act as novel biomarkers in predicting diagnosis of hepatocellular carcinoma publication-title: Cell Physiol Biochem – volume: 22 start-page: 370 year: 2015 end-page: 6 article-title: A lncRNA regulates alternative splicing establishment of a splicing‐specific chromatin signature publication-title: Nat Struct Mol Biol – volume: 117 start-page: 201 year: 2013 end-page: 35 article-title: Sphingosine kinase 1 in cancer publication-title: Adv Cancer Res – volume: 136 start-page: 709 year: 2015 end-page: 20 article-title: Loss of expression of the tumour suppressor gene AIMP3 predicts survival following radiotherapy in muscle‐invasive bladder cancer publication-title: Int J Cancer – volume: 16 start-page: 616 year: 2014 end-page: 26 article-title: NRAV, a long noncoding RNA, modulates antiviral responses through suppression of interferon‐stimulated gene transcription publication-title: Cell Host Microbe – volume: 71 start-page: 6320 year: 2011 end-page: 6 article-title: Long noncoding RNA HOTAIR regulates polycomb‐dependent chromatin modification and is associated with poor prognosis in colorectal cancers publication-title: Cancer Res – volume: 24 start-page: 7443 year: 2005 end-page: 54 article-title: Epithelial‐mesenchymal transition in development and cancer: role of phosphatidylinositol 3’ kinase/AKT pathways publication-title: Oncogene – volume: 8 start-page: 50 year: 2015 article-title: Long non‐coding RNA ANRIL is upregulated in hepatocellular carcinoma and regulates cell apoptosis by epigenetic silencing of KLF2 publication-title: J Hematol Oncol – volume: 429 start-page: 571 year: 2004 end-page: 4 article-title: Intergenic transcription is required to repress the SER3 gene publication-title: Nature – volume: 23 start-page: 1843 year: 2015 end-page: 53 article-title: Long noncoding RNA CUDR regulates HULC and beta‐catenin to govern human liver stem cell malignant differentiation publication-title: Mol Ther – volume: 2015 start-page: 191029 year: 2015 article-title: HULC and H19 played different roles in overall and disease‐free survival from hepatocellular carcinoma after curative hepatectomy: a preliminary analysis from gene expression omnibus publication-title: Dis Markers – volume: 2013 start-page: 136106 year: 2013 article-title: Plasma HULC as a promising novel biomarker for the detection of hepatocellular carcinoma publication-title: BioMed Res Int – volume: 16 start-page: 435 year: 2012 end-page: 48 article-title: Human beta cell transcriptome analysis uncovers lncRNAs that are tissue‐specific, dynamically regulated, and abnormally expressed in type 2 diabetes publication-title: Cell Metab – volume: 97 start-page: 380 year: 2011 end-page: 5 article-title: Expression of AIMP1, 2 and 3, the scaffolds for the multi‐tRNA synthetase complex, is downregulated in gastric and colorectal cancer publication-title: Tumori – volume: 21 start-page: 688 year: 2009 end-page: 92 article-title: Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis publication-title: Eur J Gastro Hepatol – volume: 75 start-page: 846 year: 2015 end-page: 57 article-title: Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR‐9‐mediated RXRA signaling pathway publication-title: Cancer Res – volume: 287 start-page: 26302 year: 2012 end-page: 11 article-title: Elevation of highly up‐regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation down‐regulating p18 publication-title: J Biol Chem – volume: 31 start-page: 358 year: 2014 end-page: 64 article-title: Role of long non‐coding RNA HULC in cell proliferation, apoptosis and tumor metastasis of gastric cancer: a clinical and investigation publication-title: Oncol Rep – volume: 47 start-page: 925 year: 2008 end-page: 33 article-title: Disturbance of circadian gene expression in hepatocellular carcinoma publication-title: Mol Carcinog – volume: 15 start-page: 182 year: 2015 article-title: Low mir‐372 expression correlates with poor prognosis and tumor metastasis in hepatocellular carcinoma publication-title: BMC Cancer – volume: 8 start-page: 2994 year: 2015 end-page: 3000 article-title: Increased expression of lncRNA HULC indicates a poor prognosis and promotes cell metastasis in osteosarcoma publication-title: Int J Clin Exp Pathol – volume: 74 start-page: 6890 year: 2014 end-page: 902 article-title: Long noncoding RNA GAPLINC regulates CD44‐dependent cell invasiveness and associates with poor prognosis of gastric cancer publication-title: Cancer Res – volume: 38 start-page: 5366 year: 2010 end-page: 83 article-title: CREB up‐regulates long non‐coding RNA, HULC expression through interaction with microRNA‐372 in liver cancer publication-title: Nucleic Acids Res – volume: 17 start-page: 79 year: 2015 end-page: 88 article-title: A long noncoding RNA perturbs the circadian rhythm of hepatoma cells to facilitate hepatocarcinogenesis publication-title: Neoplasia – volume: 6 start-page: 26359 year: 2015 end-page: 72 article-title: Specificity protein (Sp) transcription factors and metformin regulate expression of the long non‐coding RNA HULC publication-title: Oncotarget – volume: 31 start-page: 346 year: 2014 article-title: Long noncoding RNA HULC is a novel biomarker of poor prognosis in patients with pancreatic cancer publication-title: Med Oncol – volume: 137 start-page: e1 year: 2009 end-page: 10 article-title: SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis publication-title: Gastroenterology – volume: 36 start-page: 6401 year: 2015 end-page: 8 article-title: Long noncoding RNAs POLR2E rs3787016 C/T and HULC rs7763881 A/C polymorphisms are associated with decreased risk of esophageal cancer publication-title: Tumour Biol – volume: 58 start-page: 1703 year: 2013 end-page: 12 article-title: Posttranscriptional destabilization of the liver‐specific long noncoding RNA HULC by the IGF2 mRNA‐binding protein 1 (IGF2BP1) publication-title: Hepatology – ident: e_1_2_8_29_1 doi: 10.1155/2013/136106 – ident: e_1_2_8_49_1 doi: 10.1371/journal.pone.0035145 – ident: e_1_2_8_24_1 doi: 10.1158/0008-5472.CAN-14-1192 – ident: e_1_2_8_13_1 doi: 10.1038/cddis.2015.203 – ident: e_1_2_8_19_1 doi: 10.1053/j.gastro.2006.08.026 – ident: e_1_2_8_11_1 doi: 10.1158/0008-5472.CAN-14-0686 – ident: e_1_2_8_12_1 doi: 10.1158/0008-5472.CAN-11-1021 – ident: e_1_2_8_45_1 doi: 10.1053/j.gastro.2009.08.005 – ident: e_1_2_8_46_1 doi: 10.1002/mc.20627 – ident: e_1_2_8_41_1 doi: 10.1038/sj.onc.1209091 – ident: e_1_2_8_34_1 doi: 10.1177/030089161109700321 – ident: e_1_2_8_39_1 doi: 10.1002/mc.20446 – ident: e_1_2_8_3_1 doi: 10.1093/hmg/ddl046 – ident: e_1_2_8_51_1 doi: 10.1159/000430387 – ident: e_1_2_8_5_1 doi: 10.1038/nsmb.3005 – ident: e_1_2_8_14_1 doi: 10.1038/onc.2012.193 – ident: e_1_2_8_31_1 doi: 10.1038/mt.2015.166 – ident: e_1_2_8_40_1 doi: 10.1016/j.neo.2014.11.004 – ident: e_1_2_8_35_1 doi: 10.1002/ijc.29022 – ident: e_1_2_8_44_1 doi: 10.5009/gnl13392 – ident: e_1_2_8_17_1 doi: 10.1186/s13045-015-0153-1 – ident: e_1_2_8_48_1 doi: 10.1186/s12885-015-1214-0 – ident: e_1_2_8_2_1 doi: 10.1038/nature11247 – ident: e_1_2_8_38_1 doi: 10.1016/B978-0-12-394274-6.00007-8 – ident: e_1_2_8_8_1 doi: 10.1016/j.cmet.2012.08.010 – ident: e_1_2_8_26_1 doi: 10.1093/nar/gkq285 – ident: e_1_2_8_37_1 doi: 10.1016/j.intimp.2015.04.028 – ident: e_1_2_8_20_1 doi: 10.1097/MEG.0b013e328306a3a2 – ident: e_1_2_8_7_1 doi: 10.1038/nature11508 – ident: e_1_2_8_10_1 doi: 10.1016/j.autrev.2015.05.004 – ident: e_1_2_8_22_1 doi: 10.1007/s12032-014-0346-4 – volume: 8 start-page: 3076 year: 2015 ident: e_1_2_8_18_1 article-title: High expression of long non‐coding RNA ANRIL is associated with poor prognosis in hepatocellular carcinoma publication-title: Int J Clin Exp Pathol – ident: e_1_2_8_52_1 doi: 10.1155/2015/191029 – ident: e_1_2_8_30_1 doi: 10.18632/oncotarget.4560 – ident: e_1_2_8_15_1 doi: 10.1038/mt.2015.170 – ident: e_1_2_8_21_1 doi: 10.3892/or.2013.2850 – volume: 8 start-page: 12956 year: 2015 ident: e_1_2_8_42_1 article-title: Molecular mechanism of HEIH and HULC in the proliferation and invasion of hepatoma cells publication-title: Int J Clin Exp Med – ident: e_1_2_8_43_1 doi: 10.2174/15680096113136660102 – ident: e_1_2_8_9_1 doi: 10.1016/j.chom.2014.10.001 – ident: e_1_2_8_50_1 doi: 10.1007/s13277-015-3328-z – ident: e_1_2_8_33_1 doi: 10.1158/0008-5472.CAN-05-3740 – ident: e_1_2_8_47_1 doi: 10.1016/j.prp.2013.07.010 – ident: e_1_2_8_36_1 doi: 10.1038/nature02538 – ident: e_1_2_8_4_1 doi: 10.1261/rna.037598.112 – ident: e_1_2_8_25_1 doi: 10.18632/oncotarget.6280 – ident: e_1_2_8_32_1 doi: 10.2174/1871520615666150716105955 – volume: 8 start-page: 2994 year: 2015 ident: e_1_2_8_23_1 article-title: Increased expression of lncRNA HULC indicates a poor prognosis and promotes cell metastasis in osteosarcoma publication-title: Int J Clin Exp Pathol – ident: e_1_2_8_27_1 doi: 10.1074/jbc.M112.342113 – ident: e_1_2_8_16_1 doi: 10.1155/2013/251098 – ident: e_1_2_8_6_1 doi: 10.1016/j.molcel.2013.08.027 – ident: e_1_2_8_28_1 doi: 10.1002/hep.26537 – reference: 26540633 - Oncotarget. 2016 Jan 5;7(1):241-54 – reference: 20423907 - Nucleic Acids Res. 2010 Sep;38(16):5366-83 – reference: 22493738 - PLoS One. 2012;7(4):e35145 – reference: 20232364 - Mol Carcinog. 2010 May;49(5):476-87 – reference: 17241883 - Gastroenterology. 2007 Jan;132(1):330-42 – reference: 21789020 - Tumori. 2011 May-Jun;97(3):380-5 – reference: 23728852 - Hepatology. 2013 Nov;58(5):1703-12 – reference: 26317792 - Oncotarget. 2015 Sep 22;6(28):26359-72 – reference: 26045809 - Int J Clin Exp Pathol. 2015 Mar 01;8(3):2994-3000 – reference: 25849144 - Nat Struct Mol Biol. 2015 May;22(5):370-6 – reference: 26550214 - Int J Clin Exp Med. 2015 Aug 15;8(8):12956-62 – reference: 22614017 - Oncogene. 2013 Mar 28;32(13):1616-25 – reference: 25874495 - Tumour Biol. 2015 Aug;36(8):6401-8 – reference: 22955616 - Nature. 2012 Sep 6;489(7414):57-74 – reference: 26136615 - Dis Markers. 2015;2015:191029 – reference: 25525793 - Cell Host Microbe. 2014 Nov 12;16(5):616-26 – reference: 24055342 - Mol Cell. 2013 Oct 10;52(1):101-12 – reference: 18444243 - Mol Carcinog. 2008 Dec;47(12):925-33 – reference: 24054033 - Pathol Res Pract. 2013 Nov;209(11):700-4 – reference: 26179263 - Anticancer Agents Med Chem. 2016;16(4):414-23 – reference: 25622901 - Neoplasia. 2015 Jan;17(1):79-88 – reference: 22685290 - J Biol Chem. 2012 Jul 27;287(31):26302-11 – reference: 26356260 - Cell Physiol Biochem. 2015;37(2):687-96 – reference: 25880458 - BMC Cancer. 2015 Mar 26;15:182 – reference: 23290781 - Adv Cancer Res. 2013;117:201-35 – reference: 21862635 - Cancer Res. 2011 Oct 15;71(20):6320-6 – reference: 16849534 - Cancer Res. 2006 Jul 15;66(14):6913-8 – reference: 15175754 - Nature. 2004 Jun 3;429(6991):571-4 – reference: 23040067 - Cell Metab. 2012 Oct 3;16(4):435-48 – reference: 25952928 - Int Immunopharmacol. 2015 Oct;28(2):901-5 – reference: 23762823 - Biomed Res Int. 2013;2013:136106 – reference: 25592151 - Cancer Res. 2015 Mar 1;75(5):846-57 – reference: 16651366 - Hum Mol Genet. 2006 Apr 15;15 Spec No 1:R17-29 – reference: 25412939 - Med Oncol. 2014 Dec;31(12):346 – reference: 25989481 - Autoimmun Rev. 2015 Sep;14(9):798-805 – reference: 25368754 - Gut Liver. 2014 Nov;8(6):662-8 – reference: 26045820 - Int J Clin Exp Pathol. 2015 Mar 01;8(3):3076-82 – reference: 23064229 - Nature. 2012 Nov 15;491(7424):454-7 – reference: 25277524 - Cancer Res. 2014 Dec 1;74(23):6890-902 – reference: 24168186 - Curr Cancer Drug Targets. 2013 Nov;13(9):963-72 – reference: 19445043 - Eur J Gastroenterol Hepatol. 2009 Jun;21(6):688-92 – reference: 26291312 - Cell Death Dis. 2015 Aug 20;6:e1858 – reference: 23862139 - Biomed Res Int. 2013;2013:251098 – reference: 26347501 - Mol Ther. 2015 Dec;23 (12 ):1843-53 – reference: 23431328 - RNA. 2013 Apr;19(4):429-42 – reference: 16288291 - Oncogene. 2005 Nov 14;24(50):7443-54 – reference: 19686743 - Gastroenterology. 2009 Nov;137(5):1816-26.e1-10 – reference: 24247585 - Oncol Rep. 2014 Jan;31(1):358-64 – reference: 25966845 - J Hematol Oncol. 2015 May 14;8:50 – reference: 24917520 - Int J Cancer. 2015 Feb 1;136(3):709-20 – reference: 26370254 - Mol Ther. 2015 Dec;23 (12 ):1899-911 |
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| Snippet | Highly up‐regulated in liver cancer (HULC) was originally identified as the most overexpressed long non‐coding RNA in hepatocellular carcinoma. Since its... Highly up‐regulated in liver cancer ( HULC ) was originally identified as the most overexpressed long non‐coding RNA in hepatocellular carcinoma. Since its... Highly up-regulated in liver cancer (HULC) was originally identified as the most overexpressed long non-coding RNA in hepatocellular carcinoma. Since its... |
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| SubjectTerms | Angiogenesis Biomarkers Bone cancer cancer Carcinogenesis - genetics Cell growth Cholesterol Colorectal cancer Colorectal carcinoma Drug development Esophageal cancer Esophagus Gastric cancer Gene expression Gene Expression Regulation, Neoplastic Genetic diversity Hepatitis Hepatitis B Hepatitis B virus - physiology Hepatocellular carcinoma HULC Humans Hyperplasia Kinases Lipid metabolism Liver cancer long non‐coding RNAs Lymphatic system Metastases Metastasis Models, Biological Molecular modelling Neoplasms - genetics Non-coding RNA oncogene Osteosarcoma Pancreatic cancer prognosis Proteins Review Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Sarcoma Sphingosine kinase Stem cells Studies Transcription factors Tumorigenesis Tumors |
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| Title | HULC: an oncogenic long non‐coding RNA in human cancer |
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