RPL36 as a prognostic marker in hepatocellular carcinoma

Ribosomal proteins (RP) play key roles in the regulation of apoptosis, multidrug resistance and carcinogenesis. The aim of this study was to investigate the expression of ribosomal protein L36 (RPL36) in hepatocellular carcinoma (HCC) and to correlate it with clinicopathological parameters and clini...

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Bibliographic Details
Published in:Pathology international Vol. 61; no. 11; pp. 638 - 644
Main Authors: Song, Myeong Jun, Jung, Chan Kwon, Park, Chung-Hwa, Hur, Wonhee, Choi, Jung Eun, Bae, Si Hyun, Choi, Jong Young, Choi, Sang Wook, Han, Nam Ik, Yoon, Seung Kew
Format: Journal Article
Language:English
Published: Melbourne, Australia Blackwell Publishing Asia 01.11.2011
Subjects:
Adult
Aged
Analysis of Variance
Animals
Biomarkers, Tumor - metabolism
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Cell Line, Tumor
Demography
Female
Follow-Up Studies
Gene Expression Regulation, Neoplastic
Hepatectomy
hepatocellular carcinoma
Humans
Liver - metabolism
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Male
Mice
Middle Aged
Prognosis
prognostic factor
Recurrence
ribosomal protein
Ribosomal Proteins - genetics
Ribosomal Proteins - metabolism
Survival Analysis
ISSN:1320-5463, 1440-1827, 1440-1827
Online Access:Get full text
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Summary:Ribosomal proteins (RP) play key roles in the regulation of apoptosis, multidrug resistance and carcinogenesis. The aim of this study was to investigate the expression of ribosomal protein L36 (RPL36) in hepatocellular carcinoma (HCC) and to correlate it with clinicopathological parameters and clinical outcome. Liver specimens were obtained from 60 HCC patients who had undergone a partial hepatectomy. Expression of RPL36 in tumor tissue and surrounding non‐tumorous tissues was evaluated on a tissue microarray by immunohistochemistry. RPL36 was expressed in 45 of 60 (75%) HCC by immunohistochemistry, but was not detected in corresponding non‐tumors. RPL36 expression correlated significantly with serum levels of albumin (P= 0.044) and prothrombin time (P= 0.026), which reflect liver synthetic function. Moreover, expression of RPL36 was found to be higher in patients with early tumor stages (I/II) (P= 0.038) or without portal vein thrombosis (P= 0.005). In univariate analysis, patients with RPL36 expression revealed better overall survival (P= 0.037). By multivariate survival analysis, RPL36 expression was found to be an independent prognostic factor for overall survival (P= 0.026). Our data suggest that RPL36 may be involved in the early stage of hepatocarcinogenesis, and it can be used as an independent and potential prognostic marker for resected HCC.
Bibliography:istex:0346B1E2F35FC80C3CEC5BDDE1CB65CA0D0E341D
ArticleID:PIN2716
ark:/67375/WNG-S6PGSFSR-R
Ethics approval: Ethics approval was provided by the institutional Ethics Review Board, The Catholic University of Korea (KC10SISI0462).
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ISSN:1320-5463
1440-1827
1440-1827
DOI:10.1111/j.1440-1827.2011.02716.x