Skeletal muscle alterations in patients with acute Covid‐19 and post‐acute sequelae of Covid‐19

Skeletal muscle‐related symptoms are common in both acute coronavirus disease (Covid)‐19 and post‐acute sequelae of Covid‐19 (PASC). In this narrative review, we discuss cellular and molecular pathways that are affected and consider these in regard to skeletal muscle involvement in other conditions,...

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Vydáno v:Journal of cachexia, sarcopenia and muscle Ročník 13; číslo 1; s. 11 - 22
Hlavní autoři: Soares, Madu N., Eggelbusch, Moritz, Naddaf, Elie, Gerrits, Karin H. L., Schaaf, Marike, Borst, Bram, Wiersinga, W. Joost, Vugt, Michele, Weijs, Peter J.M., Murray, Andrew J., Wüst, Rob C.I.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Germany John Wiley & Sons, Inc 01.02.2022
John Wiley and Sons Inc
Wiley
Témata:
Atrophy
Chronic obstructive pulmonary disease
Coronaviruses
COVID-19
Disease Progression
Dyspnea
Guillain-Barre syndrome
Hospitalization
Humans
Illnesses
Inflammation
Intensive care
Long COVID
Metabolism
Mortality
Muscle wasting
Muscle Weakness
Muscle, Skeletal
Musculoskeletal system
Patients
Respiratory diseases
Review
Reviews
Risk factors
Sarcopenia
SARS-CoV-2
Sepsis
Severe acute respiratory syndrome coronavirus 2
Skeletal muscle
Ventilators
Inflammation
Covid-19
Metabolism
Muscle wasting
Skeletal muscle
ISSN:2190-5991, 2190-6009, 2190-6009
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Abstract Skeletal muscle‐related symptoms are common in both acute coronavirus disease (Covid)‐19 and post‐acute sequelae of Covid‐19 (PASC). In this narrative review, we discuss cellular and molecular pathways that are affected and consider these in regard to skeletal muscle involvement in other conditions, such as acute respiratory distress syndrome, critical illness myopathy, and post‐viral fatigue syndrome. Patients with severe Covid‐19 and PASC suffer from skeletal muscle weakness and exercise intolerance. Histological sections present muscle fibre atrophy, metabolic alterations, and immune cell infiltration. Contributing factors to weakness and fatigue in patients with severe Covid‐19 include systemic inflammation, disuse, hypoxaemia, and malnutrition. These factors also contribute to post‐intensive care unit (ICU) syndrome and ICU‐acquired weakness and likely explain a substantial part of Covid‐19‐acquired weakness. The skeletal muscle weakness and exercise intolerance associated with PASC are more obscure. Direct severe acute respiratory syndrome coronavirus (SARS‐CoV)‐2 viral infiltration into skeletal muscle or an aberrant immune system likely contribute. Similarities between skeletal muscle alterations in PASC and chronic fatigue syndrome deserve further study. Both SARS‐CoV‐2‐specific factors and generic consequences of acute disease likely underlie the observed skeletal muscle alterations in both acute Covid‐19 and PASC.
AbstractList Skeletal muscle-related symptoms are common in both acute coronavirus disease (Covid)-19 and post-acute sequelae of Covid-19 (PASC). In this narrative review, we discuss cellular and molecular pathways that are affected and consider these in regard to skeletal muscle involvement in other conditions, such as acute respiratory distress syndrome, critical illness myopathy, and post-viral fatigue syndrome. Patients with severe Covid-19 and PASC suffer from skeletal muscle weakness and exercise intolerance. Histological sections present muscle fibre atrophy, metabolic alterations, and immune cell infiltration. Contributing factors to weakness and fatigue in patients with severe Covid-19 include systemic inflammation, disuse, hypoxaemia, and malnutrition. These factors also contribute to post-intensive care unit (ICU) syndrome and ICU-acquired weakness and likely explain a substantial part of Covid-19-acquired weakness. The skeletal muscle weakness and exercise intolerance associated with PASC are more obscure. Direct severe acute respiratory syndrome coronavirus (SARS-CoV)-2 viral infiltration into skeletal muscle or an aberrant immune system likely contribute. Similarities between skeletal muscle alterations in PASC and chronic fatigue syndrome deserve further study. Both SARS-CoV-2-specific factors and generic consequences of acute disease likely underlie the observed skeletal muscle alterations in both acute Covid-19 and PASC.
Abstract Skeletal muscle‐related symptoms are common in both acute coronavirus disease (Covid)‐19 and post‐acute sequelae of Covid‐19 (PASC). In this narrative review, we discuss cellular and molecular pathways that are affected and consider these in regard to skeletal muscle involvement in other conditions, such as acute respiratory distress syndrome, critical illness myopathy, and post‐viral fatigue syndrome. Patients with severe Covid‐19 and PASC suffer from skeletal muscle weakness and exercise intolerance. Histological sections present muscle fibre atrophy, metabolic alterations, and immune cell infiltration. Contributing factors to weakness and fatigue in patients with severe Covid‐19 include systemic inflammation, disuse, hypoxaemia, and malnutrition. These factors also contribute to post‐intensive care unit (ICU) syndrome and ICU‐acquired weakness and likely explain a substantial part of Covid‐19‐acquired weakness. The skeletal muscle weakness and exercise intolerance associated with PASC are more obscure. Direct severe acute respiratory syndrome coronavirus (SARS‐CoV)‐2 viral infiltration into skeletal muscle or an aberrant immune system likely contribute. Similarities between skeletal muscle alterations in PASC and chronic fatigue syndrome deserve further study. Both SARS‐CoV‐2‐specific factors and generic consequences of acute disease likely underlie the observed skeletal muscle alterations in both acute Covid‐19 and PASC.
Skeletal muscle-related symptoms are common in both acute coronavirus disease (Covid)-19 and post-acute sequelae of Covid-19 (PASC). In this narrative review, we discuss cellular and molecular pathways that are affected and consider these in regard to skeletal muscle involvement in other conditions, such as acute respiratory distress syndrome, critical illness myopathy, and post-viral fatigue syndrome. Patients with severe Covid-19 and PASC suffer from skeletal muscle weakness and exercise intolerance. Histological sections present muscle fibre atrophy, metabolic alterations, and immune cell infiltration. Contributing factors to weakness and fatigue in patients with severe Covid-19 include systemic inflammation, disuse, hypoxaemia, and malnutrition. These factors also contribute to post-intensive care unit (ICU) syndrome and ICU-acquired weakness and likely explain a substantial part of Covid-19-acquired weakness. The skeletal muscle weakness and exercise intolerance associated with PASC are more obscure. Direct severe acute respiratory syndrome coronavirus (SARS-CoV)-2 viral infiltration into skeletal muscle or an aberrant immune system likely contribute. Similarities between skeletal muscle alterations in PASC and chronic fatigue syndrome deserve further study. Both SARS-CoV-2-specific factors and generic consequences of acute disease likely underlie the observed skeletal muscle alterations in both acute Covid-19 and PASC.Skeletal muscle-related symptoms are common in both acute coronavirus disease (Covid)-19 and post-acute sequelae of Covid-19 (PASC). In this narrative review, we discuss cellular and molecular pathways that are affected and consider these in regard to skeletal muscle involvement in other conditions, such as acute respiratory distress syndrome, critical illness myopathy, and post-viral fatigue syndrome. Patients with severe Covid-19 and PASC suffer from skeletal muscle weakness and exercise intolerance. Histological sections present muscle fibre atrophy, metabolic alterations, and immune cell infiltration. Contributing factors to weakness and fatigue in patients with severe Covid-19 include systemic inflammation, disuse, hypoxaemia, and malnutrition. These factors also contribute to post-intensive care unit (ICU) syndrome and ICU-acquired weakness and likely explain a substantial part of Covid-19-acquired weakness. The skeletal muscle weakness and exercise intolerance associated with PASC are more obscure. Direct severe acute respiratory syndrome coronavirus (SARS-CoV)-2 viral infiltration into skeletal muscle or an aberrant immune system likely contribute. Similarities between skeletal muscle alterations in PASC and chronic fatigue syndrome deserve further study. Both SARS-CoV-2-specific factors and generic consequences of acute disease likely underlie the observed skeletal muscle alterations in both acute Covid-19 and PASC.
Author Soares, Madu N.
Gerrits, Karin H. L.
Murray, Andrew J.
Wüst, Rob C.I.
Vugt, Michele
Naddaf, Elie
Weijs, Peter J.M.
Wiersinga, W. Joost
Eggelbusch, Moritz
Schaaf, Marike
Borst, Bram
AuthorAffiliation 4 Department of Neurology Mayo Clinic Rochester MN USA
7 Faculty of Health, Center of Expertise Urban Vitality Amsterdam University of Applied Sciences Amsterdam The Netherlands
3 Faculty of Sports and Nutrition, Center of Expertise Urban Vitality Amsterdam University of Applied Sciences Amsterdam The Netherlands
6 Department of Rehabilitation Amsterdam UMC, University of Amsterdam, Amsterdam Movement Sciences Amsterdam The Netherlands
11 Department of Physiology, Development and Neuroscience University of Cambridge Cambridge UK
1 Laboratory for Myology, Faculty of Behavioural and Movement Sciences Amsterdam Movement Sciences, Vrije Universiteit Amsterdam Amsterdam The Netherlands
8 Department of Pulmonary Diseases Radboud University Medical Center Nijmegen The Netherlands
10 Department of Internal Medicine, Division of Infectious Diseases Amsterdam University Medical Centers ‐ Location AMC, University of Amsterdam Amsterdam The Netherlands
2 Department of Nutrition and Dietetics Amsterdam UMC
AuthorAffiliation_xml – name: 1 Laboratory for Myology, Faculty of Behavioural and Movement Sciences Amsterdam Movement Sciences, Vrije Universiteit Amsterdam Amsterdam The Netherlands
– name: 3 Faculty of Sports and Nutrition, Center of Expertise Urban Vitality Amsterdam University of Applied Sciences Amsterdam The Netherlands
– name: 6 Department of Rehabilitation Amsterdam UMC, University of Amsterdam, Amsterdam Movement Sciences Amsterdam The Netherlands
– name: 5 Merem Medical Rehabilitation Hilversum The Netherlands
– name: 8 Department of Pulmonary Diseases Radboud University Medical Center Nijmegen The Netherlands
– name: 11 Department of Physiology, Development and Neuroscience University of Cambridge Cambridge UK
– name: 7 Faculty of Health, Center of Expertise Urban Vitality Amsterdam University of Applied Sciences Amsterdam The Netherlands
– name: 4 Department of Neurology Mayo Clinic Rochester MN USA
– name: 9 Center for Experimental and Molecular Medicine (CEMM) Amsterdam University Medical Centers ‐ Location AMC, University of Amsterdam Amsterdam The Netherlands
– name: 10 Department of Internal Medicine, Division of Infectious Diseases Amsterdam University Medical Centers ‐ Location AMC, University of Amsterdam Amsterdam The Netherlands
– name: 2 Department of Nutrition and Dietetics Amsterdam UMC, Location VUmc, Amsterdam Movement Sciences Amsterdam The Netherlands
Author_xml – sequence: 1
  givenname: Madu N.
  surname: Soares
  fullname: Soares, Madu N.
  organization: Amsterdam Movement Sciences, Vrije Universiteit Amsterdam
– sequence: 2
  givenname: Moritz
  orcidid: 0000-0002-4006-4063
  surname: Eggelbusch
  fullname: Eggelbusch, Moritz
  organization: Amsterdam University of Applied Sciences
– sequence: 3
  givenname: Elie
  orcidid: 0000-0001-6212-1236
  surname: Naddaf
  fullname: Naddaf, Elie
  organization: Mayo Clinic
– sequence: 4
  givenname: Karin H. L.
  surname: Gerrits
  fullname: Gerrits, Karin H. L.
  organization: Merem Medical Rehabilitation
– sequence: 5
  givenname: Marike
  surname: Schaaf
  fullname: Schaaf, Marike
  organization: Amsterdam University of Applied Sciences
– sequence: 6
  givenname: Bram
  orcidid: 0000-0002-4597-2722
  surname: Borst
  fullname: Borst, Bram
  organization: Radboud University Medical Center
– sequence: 7
  givenname: W. Joost
  orcidid: 0000-0003-2277-1343
  surname: Wiersinga
  fullname: Wiersinga, W. Joost
  organization: Amsterdam University Medical Centers ‐ Location AMC, University of Amsterdam
– sequence: 8
  givenname: Michele
  orcidid: 0000-0001-8365-2482
  surname: Vugt
  fullname: Vugt, Michele
  organization: Amsterdam University Medical Centers ‐ Location AMC, University of Amsterdam
– sequence: 9
  givenname: Peter J.M.
  orcidid: 0000-0001-8281-0426
  surname: Weijs
  fullname: Weijs, Peter J.M.
  organization: Amsterdam University of Applied Sciences
– sequence: 10
  givenname: Andrew J.
  orcidid: 0000-0002-0929-9315
  surname: Murray
  fullname: Murray, Andrew J.
  organization: University of Cambridge
– sequence: 11
  givenname: Rob C.I.
  orcidid: 0000-0003-3781-5177
  surname: Wüst
  fullname: Wüst, Rob C.I.
  email: r.wust@vu.nl
  organization: Amsterdam Movement Sciences, Vrije Universiteit Amsterdam
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34997689$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright 2021 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.
2022. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: 2021 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.
– notice: 2022. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Issue 1
Keywords Inflammation
Covid-19
Metabolism
Muscle wasting
Skeletal muscle
Language English
License Attribution-NonCommercial-NoDerivs
2021 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.
This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
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Notes Madu N. Soares and Moritz Eggelbusch have equal contribution.
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Snippet Skeletal muscle‐related symptoms are common in both acute coronavirus disease (Covid)‐19 and post‐acute sequelae of Covid‐19 (PASC). In this narrative review,...
Skeletal muscle-related symptoms are common in both acute coronavirus disease (Covid)-19 and post-acute sequelae of Covid-19 (PASC). In this narrative review,...
Abstract Skeletal muscle‐related symptoms are common in both acute coronavirus disease (Covid)‐19 and post‐acute sequelae of Covid‐19 (PASC). In this narrative...
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StartPage 11
SubjectTerms Atrophy
Chronic obstructive pulmonary disease
Coronaviruses
COVID-19
Disease Progression
Dyspnea
Guillain-Barre syndrome
Hospitalization
Humans
Illnesses
Inflammation
Intensive care
Long COVID
Metabolism
Mortality
Muscle wasting
Muscle Weakness
Muscle, Skeletal
Musculoskeletal system
Patients
Respiratory diseases
Review
Reviews
Risk factors
Sarcopenia
SARS-CoV-2
Sepsis
Severe acute respiratory syndrome coronavirus 2
Skeletal muscle
Ventilators
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Title Skeletal muscle alterations in patients with acute Covid‐19 and post‐acute sequelae of Covid‐19
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