Mechanistic biomarkers provide early and sensitive detection of acetaminophen‐induced acute liver injury at first presentation to hospital

Acetaminophen overdose is a common reason for hospital admission and the most frequent cause of hepatotoxicity in the Western world. Early identification would facilitate patient‐individualized treatment strategies. We investigated the potential of a panel of novel biomarkers (with enhanced liver ex...

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Bibliographic Details
Published in:	Hepatology (Baltimore, Md.) Vol. 58; no. 2; pp. 777 - 787
Main Authors:	Antoine, Daniel J., Dear, James W., Lewis, Philip Starkey, Platt, Vivien, Coyle, Judy, Masson, Moyra, Thanacoody, Ruben H., Gray, Alasdair J., Webb, David J., Moggs, Jonathan G., Bateman, D. Nicholas, Goldring, Christopher E., Park, B. Kevin
Format:	Journal Article
Language:	English
Published:	United States Wolters Kluwer Health, Inc 01.08.2013 WILEY-VCH Verlag
Subjects:	Acetaminophen - adverse effects Adult Alanine Transaminase - metabolism Biomarkers Biomarkers - blood Chemical and Drug Induced Liver Injury - blood Chemical and Drug Induced Liver Injury - diagnosis Disease Management Female Glutamate Dehydrogenase - metabolism Hepatology HMGB1 Protein - blood Hospitalization Humans Keratin-18 - blood Liver Liver - metabolism Liver Injury/Regeneration Male MicroRNAs - blood Middle Aged Patients Sensitivity and Specificity Time Factors
ISSN:	0270-9139, 1527-3350, 1527-3350
Online Access:	Get full text
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