Milk Fat Globule‐Epidermal Growth Factor 8 (MFG‐E8) Is a Novel Anti‐inflammatory Factor in Rheumatoid Arthritis in Mice and Humans

ABSTRACT Milk fat globule‐epidermal growth factor 8 (MFG‐E8) is an anti‐inflammatory glycoprotein that mediates the clearance of apoptotic cells and is implicated in the pathogenesis of autoimmune and inflammatory diseases. Because MFG‐E8 also controls bone metabolism, we investigated its role in rh...

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Bibliographic Details
Published in:	Journal of bone and mineral research Vol. 31; no. 3; pp. 596 - 605
Main Authors:	Albus, Elise, Sinningen, Kathrin, Winzer, Maria, Thiele, Sylvia, Baschant, Ulrike, Hannemann, Anke, Fantana, Julia, Tausche, Anne‐Kathrin, Wallaschofski, Henri, Nauck, Matthias, Völzke, Henry, Grossklaus, Sylvia, Chavakis, Triantafyllos, Udey, Mark C, Hofbauer, Lorenz C, Rauner, Martina
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01.03.2016
Subjects:	Aged Animals Anti-Inflammatory Agents - metabolism Antigens, Surface - blood Antigens, Surface - metabolism Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Bone Resorption - pathology Cytokines - metabolism Disease Progression Down-Regulation Female Humans INFLAMMATION Inflammation - pathology Inflammation Mediators - metabolism Joints - pathology Lipopolysaccharides Male MFG‐E8 Mice, Inbred C57BL Mice, Knockout Middle Aged Milk Proteins - blood Milk Proteins - metabolism Neutrophil Infiltration NEUTROPHILS; BONE LOSS RHEUMATOID ARTHRITIS Tumor Necrosis Factor-alpha RHEUMATOID ARTHRITIS MFG-E8 INFLAMMATION NEUTROPHILS; BONE LOSS
ISSN:	0884-0431, 1523-4681
Online Access:	Get full text
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