Applications of Multicomponent Reactions to the Synthesis of Diverse Heterocyclic Scaffolds

The sequencing of multicomponent reactions (MCRs) and subsequent cyclization reactions is a powerful stratagem for the rapid synthesis of diverse heterocyclic scaffolds. The optimal MCR is sufficiently flexible that it can be employed to generate adducts bearing a variety of functional groups that m...

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Bibliographic Details
Published in:Chemistry : a European journal Vol. 15; no. 6; pp. 1300 - 1308
Main Authors: Sunderhaus, James D., Martin, Stephen F.
Format: Journal Article
Language:English
Published: Weinheim WILEY-VCH Verlag 26.01.2009
WILEY‐VCH Verlag
Subjects:
Amides - chemical synthesis
Amides - chemistry
Biological Products - chemical synthesis
Biological Products - chemistry
Cyclization
diversity-oriented synthesis
heterocycles
Heterocyclic Compounds - chemical synthesis
Heterocyclic Compounds - chemistry
molecular diversity
multicomponent reactions
ISSN:0947-6539, 1521-3765, 1521-3765
Online Access:Get full text
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Summary:The sequencing of multicomponent reactions (MCRs) and subsequent cyclization reactions is a powerful stratagem for the rapid synthesis of diverse heterocyclic scaffolds. The optimal MCR is sufficiently flexible that it can be employed to generate adducts bearing a variety of functional groups that may then be selectively paired to enable different cyclization manifolds, thereby leading to a diverse collection of products. The growing interest in diversity‐oriented synthesis has led to increased attention to this paradigm for library synthesis, which has inspired many advances in the design and implementation of MCRs for the construction of diverse heterocyclic scaffolds. So much from so little! The sequencing of multicomponent reactions (MCRs) with subsequent cyclization reactions is a powerful method for generating diverse collections of functionalized heterocyclic scaffolds (see scheme).
Bibliography:National Institutes of Health - No. GM 25439
ark:/67375/WNG-XCCFPZ9C-T
Merck Research Laboratories
Pfizer
istex:1F3E8C6B70F934DD3343DF99941B964F44377A36
Robert A. Welch Foundation
ArticleID:CHEM200802140
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0947-6539
1521-3765
1521-3765
DOI:10.1002/chem.200802140