Applications of Multicomponent Reactions to the Synthesis of Diverse Heterocyclic Scaffolds

The sequencing of multicomponent reactions (MCRs) and subsequent cyclization reactions is a powerful stratagem for the rapid synthesis of diverse heterocyclic scaffolds. The optimal MCR is sufficiently flexible that it can be employed to generate adducts bearing a variety of functional groups that m...

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Vydáno v:	Chemistry : a European journal Ročník 15; číslo 6; s. 1300 - 1308
Hlavní autoři:	Sunderhaus, James D., Martin, Stephen F.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Weinheim WILEY-VCH Verlag 26.01.2009 WILEY‐VCH Verlag
Témata:	Amides - chemical synthesis Amides - chemistry Biological Products - chemical synthesis Biological Products - chemistry Cyclization diversity-oriented synthesis heterocycles Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry molecular diversity multicomponent reactions
ISSN:	0947-6539, 1521-3765, 1521-3765
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	The sequencing of multicomponent reactions (MCRs) and subsequent cyclization reactions is a powerful stratagem for the rapid synthesis of diverse heterocyclic scaffolds. The optimal MCR is sufficiently flexible that it can be employed to generate adducts bearing a variety of functional groups that may then be selectively paired to enable different cyclization manifolds, thereby leading to a diverse collection of products. The growing interest in diversity‐oriented synthesis has led to increased attention to this paradigm for library synthesis, which has inspired many advances in the design and implementation of MCRs for the construction of diverse heterocyclic scaffolds. So much from so little! The sequencing of multicomponent reactions (MCRs) with subsequent cyclization reactions is a powerful method for generating diverse collections of functionalized heterocyclic scaffolds (see scheme).
AbstractList	The sequencing of multicomponent reactions (MCRs) and subsequent cyclization reactions is a powerful stratagem for the rapid synthesis of diverse heterocyclic scaffolds. The optimal MCR is sufficiently flexible that it can be employed to generate adducts bearing a variety of functional groups that may then be selectively paired to enable different cyclization manifolds, thereby leading to a diverse collection of products. The growing interest in diversity-oriented synthesis has led to increased attention to this paradigm for library synthesis, which has inspired many advances in the design and implementation of MCRs for the construction of diverse heterocyclic scaffolds.The sequencing of multicomponent reactions (MCRs) and subsequent cyclization reactions is a powerful stratagem for the rapid synthesis of diverse heterocyclic scaffolds. The optimal MCR is sufficiently flexible that it can be employed to generate adducts bearing a variety of functional groups that may then be selectively paired to enable different cyclization manifolds, thereby leading to a diverse collection of products. The growing interest in diversity-oriented synthesis has led to increased attention to this paradigm for library synthesis, which has inspired many advances in the design and implementation of MCRs for the construction of diverse heterocyclic scaffolds. The sequencing of multicomponent reactions (MCRs) and subsequent cyclization reactions is a powerful stratagem for the rapid synthesis of diverse heterocyclic scaffolds. The optimal MCR is sufficiently flexible that it can be employed to generate adducts bearing a variety of functional groups that may then be selectively paired to enable different cyclization manifolds, thereby leading to a diverse collection of products. The growing interest in diversity-oriented synthesis has led to increased attention to this paradigm for library synthesis, which has inspired many advances in the design and implementation of MCRs for the construction of diverse heterocyclic scaffolds. The sequencing of multicomponent reactions (MCRs) and subsequent cyclization reactions is a powerful stratagem for the rapid synthesis of diverse heterocyclic scaffolds. The optimal MCR is sufficiently flexible that it can be employed to generate adducts bearing a variety of functional groups that may then be selectively paired to enable different cyclization manifolds, thereby leading to a diverse collection of products. The growing interest in diversity‐oriented synthesis has led to increased attention to this paradigm for library synthesis, which has inspired many advances in the design and implementation of MCRs for the construction of diverse heterocyclic scaffolds. So much from so little! The sequencing of multicomponent reactions (MCRs) with subsequent cyclization reactions is a powerful method for generating diverse collections of functionalized heterocyclic scaffolds (see scheme).
Author	Sunderhaus, James D. Martin, Stephen F.
Author_xml	– sequence: 1 givenname: James D. surname: Sunderhaus fullname: Sunderhaus, James D. organization: Department of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station A5300, Austin TX 78712 (USA), Fax: (+1) 512-471-4180 – sequence: 2 givenname: Stephen F. surname: Martin fullname: Martin, Stephen F. email: sfmartin@mail.utexas.edu organization: Department of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station A5300, Austin TX 78712 (USA), Fax: (+1) 512-471-4180
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/19132705$$D View this record in MEDLINE/PubMed
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Snippet	The sequencing of multicomponent reactions (MCRs) and subsequent cyclization reactions is a powerful stratagem for the rapid synthesis of diverse heterocyclic...
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SubjectTerms	Amides - chemical synthesis Amides - chemistry Biological Products - chemical synthesis Biological Products - chemistry Cyclization diversity-oriented synthesis heterocycles Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry molecular diversity multicomponent reactions
Title	Applications of Multicomponent Reactions to the Synthesis of Diverse Heterocyclic Scaffolds
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