Single-cell analysis of skeletal muscle macrophages reveals age-associated functional subpopulations

Tissue-resident macrophages represent a group of highly responsive innate immune cells that acquire diverse functions by polarizing toward distinct subpopulations. The subpopulations of macrophages that reside in skeletal muscle (SKM) and their changes during aging are poorly characterized. By singl...

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Bibliographic Details
Published in:	eLife Vol. 11
Main Authors:	Krasniewski, Linda K, Chakraborty, Papiya, Cui, Chang-Yi, Mazan-Mamczarz, Krystyna, Dunn, Christopher, Piao, Yulan, Fan, Jinshui, Shi, Changyou, Wallace, Tonya, Nguyen, Cuong, Rathbun, Isabelle A, Munk, Rachel, Tsitsipatis, Dimitrios, De, Supriyo, Sen, Payel, Ferrucci, Luigi, Gorospe, Myriam
Format:	Journal Article
Language:	English
Published:	England eLife Sciences Publications Ltd 19.10.2022 eLife Sciences Publications, Ltd
Subjects:	Aging Animals Approximation Biomarkers - metabolism Cell adhesion & migration Cell Biology Cell growth Cytokines Flow cytometry Gene expression Genomics Inflammation Lyve1 Macrophages Macrophages - metabolism Male MHCII Mice Muscle, Skeletal - metabolism muscle-resident macrophages Musculoskeletal system Neutrophils Ontology Phagocytes Phagocytes - metabolism Proteins Senescence Single-Cell Analysis Skeletal muscle Transcriptome Transcriptomics mouse Lyve1 cell biology MHCII flow cytometry aging muscle-resident macrophages single-cell analysis
ISSN:	2050-084X, 2050-084X
Online Access:	Get full text
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