The effect of Lu AG09222 on PACAP38- and VIP-induced vasodilation, heart rate increase, and headache in healthy subjects: an interventional, randomized, double-blind, parallel-group, placebo-controlled study

Background Pituitary adenylate cyclase-activating polypeptide (PACAP), structurally related to vasoactive intestinal peptide (VIP), is one of the important mediators in the pathogenesis of migraine and is known to dilate cranial arteries and induce headache and migraine. Our objective was to determi...

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Bibliographic Details
Published in:	Journal of headache and pain Vol. 24; no. 1; pp. 60 - 12
Main Authors:	Rasmussen, Nadja Bredo, Deligianni, Christina, Christensen, Casper Emil, Karlsson, William Kristian, Al-Khazali, Haidar Muhsen, Van de Casteele, Tom, Granhall, Charlotte, Amin, Faisal Mohammad, Ashina, Messoud
Format:	Journal Article
Language:	English
Published:	Milan Springer Milan 25.05.2023 Springer Nature B.V BMC
Subjects:	Antibodies, Monoclonal, Humanized - therapeutic use Arteries Blood flow Double-Blind Method Double-blind studies Headache Headaches Healthy Volunteers Heart Rate Humans Internal Medicine Medicine Medicine & Public Health Migraine Migraine disorders Migraine Disorders - therapy Migraine treatment Monoclonal antibodies Monoclonal antibody Neurology Pain Medicine Pituitary Adenylate Cyclase-Activating Polypeptide Placebos Vasoactive agents Vasoactive Intestinal Peptide Vasodilation Pituitary adenylate cyclase-activating polypeptide Migraine disorders Monoclonal antibody Migraine Migraine treatment
ISSN:	1129-2377, 1129-2369, 1129-2377
Online Access:	Get full text
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