Structural and mechanistic characterization of bifunctional heparan sulfate N-deacetylase-N-sulfotransferase 1

Heparan sulfate (HS) polysaccharides are major constituents of the extracellular matrix, which are involved in myriad structural and signaling processes. Mature HS polysaccharides contain complex, non-templated patterns of sulfation and epimerization, which mediate interactions with diverse protein...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 1326 - 17
Main Authors:	Mycroft-West, Courtney J., Abdelkarim, Sahar, Duyvesteyn, Helen M. E., Gandhi, Neha S., Skidmore, Mark A., Owens, Raymond J., Wu, Liang
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 13.02.2024 Nature Publishing Group Nature Portfolio
Subjects:	101/28 631/45/607/1172 631/45/72/1205 631/535/1258/1259 639/638/45/607 82/1 82/80 Biosynthesis Catalytic Domain Cooperativity Cryoelectron Microscopy Electron microscopy Extracellular matrix Extracellular Matrix - metabolism Glucosamine Heparan sulfate Heparitin Sulfate - metabolism Humanities and Social Sciences Humans multidisciplinary N-Deacetylase N-sulfotransferase Nanobodies Polysaccharides Saccharides Science Science (multidisciplinary) Structural analysis Substrates Sulfates Sulfation Sulfotransferase Sulfotransferases - metabolism Topology
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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