Cell-autonomous effect of cardiomyocyte branched-chain amino acid catabolism in heart failure in mice

Parallel to major changes in fatty acid and glucose metabolism, defect in branched-chain amino acid (BCAA) catabolism has also been recognized as a metabolic hallmark and potential therapeutic target for heart failure. However, BCAA catabolic enzymes are ubiquitously expressed in all cell types and...

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Veröffentlicht in:	Acta pharmacologica Sinica Jg. 44; H. 7; S. 1380 - 1390
Hauptverfasser:	Yu, Jia-yu, Cao, Nancy, Rau, Christoph D., Lee, Ro-Po, Yang, Jieping, Flach, Rachel J. Roth, Petersen, Lauren, Zhu, Cansheng, Pak, Yea-Lyn, Miller, Russell A., Liu, Yunxia, Wang, Yibin, Li, Zhaoping, Sun, Haipeng, Gao, Chen
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Singapore Springer Nature Singapore 01.07.2023 Nature Publishing Group
Schlagworte:	Amino acids Amino Acids, Branched-Chain - metabolism Amino Acids, Branched-Chain - therapeutic use Animal models Animals Biomedical and Life Sciences Biomedicine Cardiac function Cardiomyocytes Congestive heart failure Diabetes Mellitus Glucose metabolism Heart failure Heart Failure - metabolism Immunology Internal Medicine Kinases Medical Microbiology Metabolic disorders Metabolism Mice Myocytes, Cardiac - metabolism Obesity - metabolism Pharmacology/Toxicology Therapeutic targets Transcriptomes Vaccine heart failure branched-chain amino acid metabolism
ISSN:	1671-4083, 1745-7254, 1745-7254
Online-Zugang:	Volltext
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