Reference equations for pulse wave velocity, augmentation index, amplitude of forward and backward wave in a European general adult population

Pulsatile hemodynamics have been shown to be independent predictors of cardiovascular events. The aim of the current study was to describe four pulsatile hemodynamic markers in a large, well-established, population-based cohort and to provide reference equations for sex- and age-based standardizatio...

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Vydáno v:Scientific reports Ročník 14; číslo 1; s. 23151 - 13
Hlavní autoři: Azizzadeh, Mohammad, Karimi, Ahmad, Breyer-Kohansal, Robab, Hartl, Sylvia, Breyer, Marie-Kathrin, Gross, Christoph, Boutouyrie, Pierre, Bruno, Rosa Maria, Hametner, Bernhard, Wassertheurer, Siegfried, Burghuber, Otto Chris, Weber, Thomas
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 05.10.2024
Nature Publishing Group
Nature Portfolio
Témata:
692/308
692/4019
692/700
Adult
Age groups
Aged
Aging
Amplitude of forward wave
Augmentation index
Backward wave
Cardiovascular diseases
Coefficient of variation
Cohort Studies
Diabetes mellitus
Drug therapy
Dyslipidemia
Female
Females
Hemodynamics
Hemodynamics - physiology
Humanities and Social Sciences
Humans
Hypertension
Lead
Male
Males
Middle Aged
multidisciplinary
Population studies
Pulse Wave Analysis - methods
Pulse wave velocity
Reference equation
Reference Values
Science
Science (multidisciplinary)
Sex differences
Standardization
Vascular Stiffness - physiology
Velocity
Wave velocity
Young Adult
Z-score
Pulse wave velocity
Z-score
Augmentation index
Reference equation
Amplitude of forward wave
Backward wave
ISSN:2045-2322, 2045-2322
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Abstract Pulsatile hemodynamics have been shown to be independent predictors of cardiovascular events. The aim of the current study was to describe four pulsatile hemodynamic markers in a large, well-established, population-based cohort and to provide reference equations for sex- and age-based standardization of these measurements. 6828 adult participants from the Austrian LEAD (Lung, hEart, sociAl, boDy) cohort study, who were free from overt cardiovascular disease, non-diabetic based on blood test results, and had no history of pharmacological treatment for hypertension, dyslipidemia, and diabetes, comprised the “reference population”. Carotid-femoral pulse wave velocity (cfPWV), augmentation index (AIx), amplitude of forward wave (Pf), and backward wave (Pb) were described in different age categories for both sexes. Sex-specific reference equations for cfPWV, AIx, Pf, and Pb with age as the predictive variable were created using the Lambda-Mu-Sigma (LMS) method. All four parameters increased with age. CfPWV and Pf were higher in males than females, especially in young and middle-age groups ( P  < 0.001). AIx was higher in females than males in all age categories ( P  < 0.001). Pb was also higher in females than males in age groups older than 40 years ( P  < 0.01). Reference equations for the skewness (Lambda), median (Mu), and coefficient of variation (Sigma) values were determined, enabling the calculation of sex- and age-standardized values (z-scores) for each individual’s pulsatile hemodynamic measurement, and an online application was developed. Reference equations derived from a large population-based dataset constitute a suitable tool for the standardization of pulsatile hemodynamics and for the accurate interpretation of vascular aging.
AbstractList Pulsatile hemodynamics have been shown to be independent predictors of cardiovascular events. The aim of the current study was to describe four pulsatile hemodynamic markers in a large, well-established, population-based cohort and to provide reference equations for sex- and age-based standardization of these measurements. 6828 adult participants from the Austrian LEAD (Lung, hEart, sociAl, boDy) cohort study, who were free from overt cardiovascular disease, non-diabetic based on blood test results, and had no history of pharmacological treatment for hypertension, dyslipidemia, and diabetes, comprised the “reference population”. Carotid-femoral pulse wave velocity (cfPWV), augmentation index (AIx), amplitude of forward wave (Pf), and backward wave (Pb) were described in different age categories for both sexes. Sex-specific reference equations for cfPWV, AIx, Pf, and Pb with age as the predictive variable were created using the Lambda-Mu-Sigma (LMS) method. All four parameters increased with age. CfPWV and Pf were higher in males than females, especially in young and middle-age groups ( P  < 0.001). AIx was higher in females than males in all age categories ( P  < 0.001). Pb was also higher in females than males in age groups older than 40 years ( P  < 0.01). Reference equations for the skewness (Lambda), median (Mu), and coefficient of variation (Sigma) values were determined, enabling the calculation of sex- and age-standardized values (z-scores) for each individual’s pulsatile hemodynamic measurement, and an online application was developed. Reference equations derived from a large population-based dataset constitute a suitable tool for the standardization of pulsatile hemodynamics and for the accurate interpretation of vascular aging.
Pulsatile hemodynamics have been shown to be independent predictors of cardiovascular events. The aim of the current study was to describe four pulsatile hemodynamic markers in a large, well-established, population-based cohort and to provide reference equations for sex- and age-based standardization of these measurements. 6828 adult participants from the Austrian LEAD (Lung, hEart, sociAl, boDy) cohort study, who were free from overt cardiovascular disease, non-diabetic based on blood test results, and had no history of pharmacological treatment for hypertension, dyslipidemia, and diabetes, comprised the "reference population". Carotid-femoral pulse wave velocity (cfPWV), augmentation index (AIx), amplitude of forward wave (Pf), and backward wave (Pb) were described in different age categories for both sexes. Sex-specific reference equations for cfPWV, AIx, Pf, and Pb with age as the predictive variable were created using the Lambda-Mu-Sigma (LMS) method. All four parameters increased with age. CfPWV and Pf were higher in males than females, especially in young and middle-age groups (P < 0.001). AIx was higher in females than males in all age categories (P < 0.001). Pb was also higher in females than males in age groups older than 40 years (P < 0.01). Reference equations for the skewness (Lambda), median (Mu), and coefficient of variation (Sigma) values were determined, enabling the calculation of sex- and age-standardized values (z-scores) for each individual's pulsatile hemodynamic measurement, and an online application was developed. Reference equations derived from a large population-based dataset constitute a suitable tool for the standardization of pulsatile hemodynamics and for the accurate interpretation of vascular aging.
Pulsatile hemodynamics have been shown to be independent predictors of cardiovascular events. The aim of the current study was to describe four pulsatile hemodynamic markers in a large, well-established, population-based cohort and to provide reference equations for sex- and age-based standardization of these measurements. 6828 adult participants from the Austrian LEAD (Lung, hEart, sociAl, boDy) cohort study, who were free from overt cardiovascular disease, non-diabetic based on blood test results, and had no history of pharmacological treatment for hypertension, dyslipidemia, and diabetes, comprised the "reference population". Carotid-femoral pulse wave velocity (cfPWV), augmentation index (AIx), amplitude of forward wave (Pf), and backward wave (Pb) were described in different age categories for both sexes. Sex-specific reference equations for cfPWV, AIx, Pf, and Pb with age as the predictive variable were created using the Lambda-Mu-Sigma (LMS) method. All four parameters increased with age. CfPWV and Pf were higher in males than females, especially in young and middle-age groups (P < 0.001). AIx was higher in females than males in all age categories (P < 0.001). Pb was also higher in females than males in age groups older than 40 years (P < 0.01). Reference equations for the skewness (Lambda), median (Mu), and coefficient of variation (Sigma) values were determined, enabling the calculation of sex- and age-standardized values (z-scores) for each individual's pulsatile hemodynamic measurement, and an online application was developed. Reference equations derived from a large population-based dataset constitute a suitable tool for the standardization of pulsatile hemodynamics and for the accurate interpretation of vascular aging.Pulsatile hemodynamics have been shown to be independent predictors of cardiovascular events. The aim of the current study was to describe four pulsatile hemodynamic markers in a large, well-established, population-based cohort and to provide reference equations for sex- and age-based standardization of these measurements. 6828 adult participants from the Austrian LEAD (Lung, hEart, sociAl, boDy) cohort study, who were free from overt cardiovascular disease, non-diabetic based on blood test results, and had no history of pharmacological treatment for hypertension, dyslipidemia, and diabetes, comprised the "reference population". Carotid-femoral pulse wave velocity (cfPWV), augmentation index (AIx), amplitude of forward wave (Pf), and backward wave (Pb) were described in different age categories for both sexes. Sex-specific reference equations for cfPWV, AIx, Pf, and Pb with age as the predictive variable were created using the Lambda-Mu-Sigma (LMS) method. All four parameters increased with age. CfPWV and Pf were higher in males than females, especially in young and middle-age groups (P < 0.001). AIx was higher in females than males in all age categories (P < 0.001). Pb was also higher in females than males in age groups older than 40 years (P < 0.01). Reference equations for the skewness (Lambda), median (Mu), and coefficient of variation (Sigma) values were determined, enabling the calculation of sex- and age-standardized values (z-scores) for each individual's pulsatile hemodynamic measurement, and an online application was developed. Reference equations derived from a large population-based dataset constitute a suitable tool for the standardization of pulsatile hemodynamics and for the accurate interpretation of vascular aging.
Abstract Pulsatile hemodynamics have been shown to be independent predictors of cardiovascular events. The aim of the current study was to describe four pulsatile hemodynamic markers in a large, well-established, population-based cohort and to provide reference equations for sex- and age-based standardization of these measurements. 6828 adult participants from the Austrian LEAD (Lung, hEart, sociAl, boDy) cohort study, who were free from overt cardiovascular disease, non-diabetic based on blood test results, and had no history of pharmacological treatment for hypertension, dyslipidemia, and diabetes, comprised the “reference population”. Carotid-femoral pulse wave velocity (cfPWV), augmentation index (AIx), amplitude of forward wave (Pf), and backward wave (Pb) were described in different age categories for both sexes. Sex-specific reference equations for cfPWV, AIx, Pf, and Pb with age as the predictive variable were created using the Lambda-Mu-Sigma (LMS) method. All four parameters increased with age. CfPWV and Pf were higher in males than females, especially in young and middle-age groups (P < 0.001). AIx was higher in females than males in all age categories (P < 0.001). Pb was also higher in females than males in age groups older than 40 years (P < 0.01). Reference equations for the skewness (Lambda), median (Mu), and coefficient of variation (Sigma) values were determined, enabling the calculation of sex- and age-standardized values (z-scores) for each individual’s pulsatile hemodynamic measurement, and an online application was developed. Reference equations derived from a large population-based dataset constitute a suitable tool for the standardization of pulsatile hemodynamics and for the accurate interpretation of vascular aging.
ArticleNumber 23151
Author Breyer, Marie-Kathrin
Hametner, Bernhard
Azizzadeh, Mohammad
Bruno, Rosa Maria
Weber, Thomas
Karimi, Ahmad
Wassertheurer, Siegfried
Breyer-Kohansal, Robab
Gross, Christoph
Burghuber, Otto Chris
Hartl, Sylvia
Boutouyrie, Pierre
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  organization: Ludwig Boltzmann Institute for Lung Health, Faculty of Medicine, Sigmund Freud Private University
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  organization: Ludwig Boltzmann Institute for Lung Health, Faculty of Medicine, Sigmund Freud Private University
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  surname: Breyer-Kohansal
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  organization: Ludwig Boltzmann Institute for Lung Health, Department of Respiratory and Pulmonary Diseases, Clinic Hietzing, Vienna Healthcare Group
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  surname: Weber
  fullname: Weber, Thomas
  organization: Department of Cardiology, Klinikum Wels-Grieskirchen
BackLink https://www.ncbi.nlm.nih.gov/pubmed/39367200$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords Pulse wave velocity
Z-score
Augmentation index
Reference equation
Amplitude of forward wave
Backward wave
Language English
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  doi: 10.1371/journal.pone.0141656
– volume: 46
  start-page: 1753
  year: 2005
  ident: 74162_CR7
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2005.07.037
– volume: 54
  start-page: 3
  year: 2009
  ident: 74162_CR18
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.109.129114
– volume: 27
  start-page: 2588
  year: 2006
  ident: 74162_CR3
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehl254
– volume: 33
  start-page: 531
  year: 2019
  ident: 74162_CR36
  publication-title: J. Hum. Hypertens.
  doi: 10.1038/s41371-019-0187-x
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Snippet Pulsatile hemodynamics have been shown to be independent predictors of cardiovascular events. The aim of the current study was to describe four pulsatile...
Abstract Pulsatile hemodynamics have been shown to be independent predictors of cardiovascular events. The aim of the current study was to describe four...
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SubjectTerms 692/308
692/4019
692/700
Adult
Age groups
Aged
Aging
Amplitude of forward wave
Augmentation index
Backward wave
Cardiovascular diseases
Coefficient of variation
Cohort Studies
Diabetes mellitus
Drug therapy
Dyslipidemia
Female
Females
Hemodynamics
Hemodynamics - physiology
Humanities and Social Sciences
Humans
Hypertension
Lead
Male
Males
Middle Aged
multidisciplinary
Population studies
Pulse Wave Analysis - methods
Pulse wave velocity
Reference equation
Reference Values
Science
Science (multidisciplinary)
Sex differences
Standardization
Vascular Stiffness - physiology
Velocity
Wave velocity
Young Adult
Z-score
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Title Reference equations for pulse wave velocity, augmentation index, amplitude of forward and backward wave in a European general adult population
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