Selection Criteria for Lung-Cancer Screening

Low-dose CT scanning reduces lung-cancer mortality. Further improvements are possible if the screened population includes a larger proportion of high-risk persons. The authors added features to the criteria for screening that improved sensitivity and positive predictive value. The National Lung Scre...

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Bibliographic Details
Published in:The New England journal of medicine Vol. 368; no. 8; pp. 728 - 736
Main Authors: Tammemägi, Martin C, Katki, Hormuzd A, Hocking, William G, Church, Timothy R, Caporaso, Neil, Kvale, Paul A, Chaturvedi, Anil K, Silvestri, Gerard A, Riley, Tom L, Commins, John, Berg, Christine D
Format: Journal Article
Language:English
Published: Waltham, MA Massachusetts Medical Society 21.02.2013
Subjects:
Area Under Curve
Biological and medical sciences
Cancer screening
Chronic obstructive pulmonary disease
Computed tomography
General aspects
Humans
Logistic Models
Lung cancer
Lung Neoplasms - diagnostic imaging
Mass Screening
Medical research
Medical sciences
Medical screening
Methods
Ovarian cancer
Patient Selection
Pneumology
Prevention and actions
Prostate
Public health. Hygiene
Public health. Hygiene-occupational medicine
Radiography, Thoracic
Risk Assessment - methods
Risk Factors
Sensitivity and Specificity
Smoking
Tomography, X-Ray Computed
Tumors of the respiratory system and mediastinum
Medicine
Lung disease
Respiratory disease
Criterion
Lung cancer
Selection
Bronchus disease
Malignant tumor
Medical screening
Cancer
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Description
Summary:Low-dose CT scanning reduces lung-cancer mortality. Further improvements are possible if the screened population includes a larger proportion of high-risk persons. The authors added features to the criteria for screening that improved sensitivity and positive predictive value. The National Lung Screening Trial (NLST) showed that lung-cancer screening with the use of low-dose computed tomography (CT) resulted in a 20% reduction in mortality from lung cancer. 1 Some organizations now recommend adoption of lung-cancer screening in clinical practice for high-risk persons if high-quality imaging, diagnostic methods, and treatment are available. 2 – 4 Most of these recommendations identify persons to be screened by applying the NLST criteria, which include an age between 55 and 74 years, a history of smoking of at least 30 pack-years, a period of less than 15 years since cessation of smoking, or some variant of these . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1211776