Mesenchymal ovarian cancer cells promote CD8+ T cell exhaustion through the LGALS3-LAG3 axis

Cancer cells often metastasize by undergoing an epithelial-mesenchymal transition (EMT). Although abundance of CD8 + T-cells in the tumor microenvironment correlates with improved survival, mesenchymal cancer cells acquire greater resistance to antitumor immunity in some cancers. We hypothesized the...

Full description

Saved in:

Bibliographic Details
Published in:	NPJ systems biology and applications Vol. 9; no. 1; pp. 61 - 17
Main Authors:	Yakubovich, Edward, Cook, David P., Rodriguez, Galaxia M., Vanderhyden, Barbara C.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 12.12.2023 Nature Publishing Group Nature Portfolio
Subjects:	631/114 631/250 631/553/2711 631/67 Bioinformatics Biomedical and Life Sciences CD8 antigen CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - pathology Computational Biology/Bioinformatics Computer Appl. in Life Sciences Female Galectin 3 - genetics Galectin 3 - metabolism Humans Immunity Inflammation Life Sciences Lymphocytes Lymphocytes T Mesenchyme Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Systems Biology T-Cell Exhaustion Tumor Microenvironment Tumors
ISSN:	2056-7189, 2056-7189
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!