Mesenchymal ovarian cancer cells promote CD8+ T cell exhaustion through the LGALS3-LAG3 axis

Cancer cells often metastasize by undergoing an epithelial-mesenchymal transition (EMT). Although abundance of CD8 + T-cells in the tumor microenvironment correlates with improved survival, mesenchymal cancer cells acquire greater resistance to antitumor immunity in some cancers. We hypothesized the...

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Veröffentlicht in:	NPJ systems biology and applications Jg. 9; H. 1; S. 61 - 17
Hauptverfasser:	Yakubovich, Edward, Cook, David P., Rodriguez, Galaxia M., Vanderhyden, Barbara C.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 12.12.2023 Nature Publishing Group Nature Portfolio
Schlagworte:	631/114 631/250 631/553/2711 631/67 Bioinformatics Biomedical and Life Sciences CD8 antigen CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - pathology Computational Biology/Bioinformatics Computer Appl. in Life Sciences Female Galectin 3 - genetics Galectin 3 - metabolism Humans Immunity Inflammation Life Sciences Lymphocytes Lymphocytes T Mesenchyme Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Systems Biology T-Cell Exhaustion Tumor Microenvironment Tumors
ISSN:	2056-7189, 2056-7189
Online-Zugang:	Volltext
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