A Randomized Trial of Protocol-Based Care for Early Septic Shock
In septic shock, the first few hours of care are critical for survival. In this study, two protocols for the care of patients with septic shock were compared with usual care with respect to 60-day mortality and other outcomes. There were no significant differences in outcome. There are more than 750...
Uloženo v:
| Vydáno v: | The New England journal of medicine Ročník 370; číslo 18; s. 1683 - 1693 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Waltham, MA
Massachusetts Medical Society
01.05.2014
|
| Témata: | |
| ISSN: | 0028-4793, 1533-4406, 1533-4406 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | In septic shock, the first few hours of care are critical for survival. In this study, two protocols for the care of patients with septic shock were compared with usual care with respect to 60-day mortality and other outcomes. There were no significant differences in outcome.
There are more than 750,000 cases of severe sepsis and septic shock in the United States each year.
1
Most patients who present with sepsis receive initial care in the emergency department, and the short-term mortality is 20% or more.
2
,
3
In 2001, Rivers et al. reported that among patients with severe sepsis or septic shock in a single urban emergency department, mortality was significantly lower among those who were treated according to a 6-hour protocol of early goal-directed therapy (EGDT) than among those who were given standard therapy (30.5% vs. 46.5%).
4
On the basis of the premise that usual care . . . |
|---|---|
| AbstractList | In a single-center study published more than a decade ago involving patients presenting to the emergency department with severe sepsis and septic shock, mortality was markedly lower among those who were treated according to a 6-hour protocol of early goal-directed therapy (EGDT), in which intravenous fluids, vasopressors, inotropes, and blood transfusions were adjusted to reach central hemodynamic targets, than among those receiving usual care. We conducted a trial to determine whether these findings were generalizable and whether all aspects of the protocol were necessary.BACKGROUNDIn a single-center study published more than a decade ago involving patients presenting to the emergency department with severe sepsis and septic shock, mortality was markedly lower among those who were treated according to a 6-hour protocol of early goal-directed therapy (EGDT), in which intravenous fluids, vasopressors, inotropes, and blood transfusions were adjusted to reach central hemodynamic targets, than among those receiving usual care. We conducted a trial to determine whether these findings were generalizable and whether all aspects of the protocol were necessary.In 31 emergency departments in the United States, we randomly assigned patients with septic shock to one of three groups for 6 hours of resuscitation: protocol-based EGDT; protocol-based standard therapy that did not require the placement of a central venous catheter, administration of inotropes, or blood transfusions; or usual care. The primary end point was 60-day in-hospital mortality. We tested sequentially whether protocol-based care (EGDT and standard-therapy groups combined) was superior to usual care and whether protocol-based EGDT was superior to protocol-based standard therapy. Secondary outcomes included longer-term mortality and the need for organ support.METHODSIn 31 emergency departments in the United States, we randomly assigned patients with septic shock to one of three groups for 6 hours of resuscitation: protocol-based EGDT; protocol-based standard therapy that did not require the placement of a central venous catheter, administration of inotropes, or blood transfusions; or usual care. The primary end point was 60-day in-hospital mortality. We tested sequentially whether protocol-based care (EGDT and standard-therapy groups combined) was superior to usual care and whether protocol-based EGDT was superior to protocol-based standard therapy. Secondary outcomes included longer-term mortality and the need for organ support.We enrolled 1341 patients, of whom 439 were randomly assigned to protocol-based EGDT, 446 to protocol-based standard therapy, and 456 to usual care. Resuscitation strategies differed significantly with respect to the monitoring of central venous pressure and oxygen and the use of intravenous fluids, vasopressors, inotropes, and blood transfusions. By 60 days, there were 92 deaths in the protocol-based EGDT group (21.0%), 81 in the protocol-based standard-therapy group (18.2%), and 86 in the usual-care group (18.9%) (relative risk with protocol-based therapy vs. usual care, 1.04; 95% confidence interval [CI], 0.82 to 1.31; P=0.83; relative risk with protocol-based EGDT vs. protocol-based standard therapy, 1.15; 95% CI, 0.88 to 1.51; P=0.31). There were no significant differences in 90-day mortality, 1-year mortality, or the need for organ support.RESULTSWe enrolled 1341 patients, of whom 439 were randomly assigned to protocol-based EGDT, 446 to protocol-based standard therapy, and 456 to usual care. Resuscitation strategies differed significantly with respect to the monitoring of central venous pressure and oxygen and the use of intravenous fluids, vasopressors, inotropes, and blood transfusions. By 60 days, there were 92 deaths in the protocol-based EGDT group (21.0%), 81 in the protocol-based standard-therapy group (18.2%), and 86 in the usual-care group (18.9%) (relative risk with protocol-based therapy vs. usual care, 1.04; 95% confidence interval [CI], 0.82 to 1.31; P=0.83; relative risk with protocol-based EGDT vs. protocol-based standard therapy, 1.15; 95% CI, 0.88 to 1.51; P=0.31). There were no significant differences in 90-day mortality, 1-year mortality, or the need for organ support.In a multicenter trial conducted in the tertiary care setting, protocol-based resuscitation of patients in whom septic shock was diagnosed in the emergency department did not improve outcomes. (Funded by the National Institute of General Medical Sciences; ProCESS ClinicalTrials.gov number, NCT00510835.).CONCLUSIONSIn a multicenter trial conducted in the tertiary care setting, protocol-based resuscitation of patients in whom septic shock was diagnosed in the emergency department did not improve outcomes. (Funded by the National Institute of General Medical Sciences; ProCESS ClinicalTrials.gov number, NCT00510835.). BackgroundIn a single-center study published more than a decade ago involving patients presenting to the emergency department with severe sepsis and septic shock, mortality was markedly lower among those who were treated according to a 6-hour protocol of early goal-directed therapy (EGDT), in which intravenous fluids, vasopressors, inotropes, and blood transfusions were adjusted to reach central hemodynamic targets, than among those receiving usual care. We conducted a trial to determine whether these findings were generalizable and whether all aspects of the protocol were necessary.MethodsIn 31 emergency departments in the United States, we randomly assigned patients with septic shock to one of three groups for 6 hours of resuscitation: protocol-based EGDT; protocol-based standard therapy that did not require the placement of a central venous catheter, administration of inotropes, or blood transfusions; or usual care. The primary end point was 60-day in-hospital mortality. We tested sequentially whether protocol-based care (EGDT and standard-therapy groups combined) was superior to usual care and whether protocol-based EGDT was superior to protocol-based standard therapy. Secondary outcomes included longer-term mortality and the need for organ support.ResultsWe enrolled 1341 patients, of whom 439 were randomly assigned to protocol-based EGDT, 446 to protocol-based standard therapy, and 456 to usual care. Resuscitation strategies differed significantly with respect to the monitoring of central venous pressure and oxygen and the use of intravenous fluids, vasopressors, inotropes, and blood transfusions. By 60 days, there were 92 deaths in the protocol-based EGDT group (21.0%), 81 in the protocol-based standard-therapy group (18.2%), and 86 in the usual-care group (18.9%) (relative risk with protocol-based therapy vs. usual care, 1.04; 95% confidence interval [CI], 0.82 to 1.31; P=0.83; relative risk with protocol-based EGDT vs. protocol-based standard therapy, 1.15; 95% CI, 0.88 to 1.51; P=0.31). There were no significant differences in 90-day mortality, 1-year mortality, or the need for organ support.ConclusionsIn a multicenter trial conducted in the tertiary care setting, protocol-based resuscitation of patients in whom septic shock was diagnosed in the emergency department did not improve outcomes. (Funded by the National Institute of General Medical Sciences; ProCESS ClinicalTrials.gov number, NCT00510835.) In a single-center study published more than a decade ago involving patients presenting to the emergency department with severe sepsis and septic shock, mortality was markedly lower among those who were treated according to a 6-hour protocol of early goal-directed therapy (EGDT), in which intravenous fluids, vasopressors, inotropes, and blood transfusions were adjusted to reach central hemodynamic targets, than among those receiving usual care. We conducted a trial to determine whether these findings were generalizable and whether all aspects of the protocol were necessary. In 31 emergency departments in the United States, we randomly assigned patients with septic shock to one of three groups for 6 hours of resuscitation: protocol-based EGDT; protocol-based standard therapy that did not require the placement of a central venous catheter, administration of inotropes, or blood transfusions; or usual care. The primary end point was 60-day in-hospital mortality. We tested sequentially whether protocol-based care (EGDT and standard-therapy groups combined) was superior to usual care and whether protocol-based EGDT was superior to protocol-based standard therapy. Secondary outcomes included longer-term mortality and the need for organ support. We enrolled 1341 patients, of whom 439 were randomly assigned to protocol-based EGDT, 446 to protocol-based standard therapy, and 456 to usual care. Resuscitation strategies differed significantly with respect to the monitoring of central venous pressure and oxygen and the use of intravenous fluids, vasopressors, inotropes, and blood transfusions. By 60 days, there were 92 deaths in the protocol-based EGDT group (21.0%), 81 in the protocol-based standard-therapy group (18.2%), and 86 in the usual-care group (18.9%) (relative risk with protocol-based therapy vs. usual care, 1.04; 95% confidence interval [CI], 0.82 to 1.31; P=0.83; relative risk with protocol-based EGDT vs. protocol-based standard therapy, 1.15; 95% CI, 0.88 to 1.51; P=0.31). There were no significant differences in 90-day mortality, 1-year mortality, or the need for organ support. In a multicenter trial conducted in the tertiary care setting, protocol-based resuscitation of patients in whom septic shock was diagnosed in the emergency department did not improve outcomes. (Funded by the National Institute of General Medical Sciences; ProCESS ClinicalTrials.gov number, NCT00510835.). In septic shock, the first few hours of care are critical for survival. In this study, two protocols for the care of patients with septic shock were compared with usual care with respect to 60-day mortality and other outcomes. There were no significant differences in outcome. There are more than 750,000 cases of severe sepsis and septic shock in the United States each year. 1 Most patients who present with sepsis receive initial care in the emergency department, and the short-term mortality is 20% or more. 2 , 3 In 2001, Rivers et al. reported that among patients with severe sepsis or septic shock in a single urban emergency department, mortality was significantly lower among those who were treated according to a 6-hour protocol of early goal-directed therapy (EGDT) than among those who were given standard therapy (30.5% vs. 46.5%). 4 On the basis of the premise that usual care . . . |
| Author | KELLUM, John A TERNDRUP, Thomas SHAPIRO, Nathan I FILBIN, Michael R WEISSFELD, Lisa A ANGUS, Derek C WANG, Henry E LOVECCHIO, Frank HUANG, David T PIKE, Francis BARNATO, Amber E YEALY, Donald M HOU, Peter C |
| Author_xml | – sequence: 1 givenname: Donald M surname: YEALY fullname: YEALY, Donald M organization: University of Pittsburgh, Pittsburgh, United States – sequence: 2 givenname: John A surname: KELLUM fullname: KELLUM, John A organization: University of Pittsburgh, Pittsburgh, United States – sequence: 3 givenname: Michael R surname: FILBIN fullname: FILBIN, Michael R organization: Massachusetts General Hospital, Boston, United States – sequence: 4 givenname: Nathan I surname: SHAPIRO fullname: SHAPIRO, Nathan I organization: Beth Israel Deaconess Medical Center, Boston, United States – sequence: 5 givenname: Derek C surname: ANGUS fullname: ANGUS, Derek C organization: University of Pittsburgh, Pittsburgh, United States – sequence: 6 givenname: David T surname: HUANG fullname: HUANG, David T organization: University of Pittsburgh, Pittsburgh, United States – sequence: 7 givenname: Amber E surname: BARNATO fullname: BARNATO, Amber E organization: University of Pittsburgh, Pittsburgh, United States – sequence: 8 givenname: Lisa A surname: WEISSFELD fullname: WEISSFELD, Lisa A organization: University of Pittsburgh, Pittsburgh, United States – sequence: 9 givenname: Francis surname: PIKE fullname: PIKE, Francis organization: University of Pittsburgh, Pittsburgh, United States – sequence: 10 givenname: Thomas surname: TERNDRUP fullname: TERNDRUP, Thomas organization: Ohio State University, Columbus, United States – sequence: 11 givenname: Henry E surname: WANG fullname: WANG, Henry E organization: University of Alabama at Birmingham, Birmingham, United States – sequence: 12 givenname: Peter C surname: HOU fullname: HOU, Peter C organization: Brigham and Women's Hospital, Boston, United States – sequence: 13 givenname: Frank surname: LOVECCHIO fullname: LOVECCHIO, Frank organization: Maricopa Medical Center, Phoenix, United States |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28361396$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/24635773$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kctv1DAQhy1URLeFI1cUCSFxCYyfSS6oZbW8VB6i5WxNHJt6SezFzlZq_3oSdQu0Un2x5Pnm0288B2QvxGAJeUrhFQWpXn9ZffockQqgCtgDsqCS81IIUHtkAcDqUlQN3ycHOa9hOlQ0j8g-E4rLquILcnRcfMfQxcFf2a44Sx77IrriW4pjNLEv32Ke3peYbOFiKlaY-svi1G5Gb4rT82h-PSYPHfbZPtndh-THu9XZ8kN58vX9x-XxSWmkoGNp2wo7oZxCUUvBOOtMjY3hVroKWmcYbylAbaq2bqpGUtcwio3jqgWQrAN-SN5cezfbdrCdsWFM2OtN8gOmSx3R69uV4M_1z3ihBQVawSx4uROk-Htr86gHn43teww2brOmklHOhKjkhD6_g67jNoVpvJmCKT7IWfjs_0R_o9x87gS82AGYDfYuYTA-_-Nqrihv1MTxa86kmHOyThs_4ujjPIjvNQU9r1rfWvXUVd7puhHfx-_SDEPWwa6He7g_m5eywA |
| CODEN | NEJMAG |
| CitedBy_id | crossref_primary_10_1016_j_ajem_2017_04_055 crossref_primary_10_1016_j_cnc_2021_08_003 crossref_primary_10_1111_aas_12810 crossref_primary_10_1016_j_cveq_2015_09_001 crossref_primary_10_3389_fmed_2020_550182 crossref_primary_10_1097_CCM_0000000000001149 crossref_primary_10_1016_j_ajem_2017_12_055 crossref_primary_10_4103_ijccm_IJCCM_41_17 crossref_primary_10_1111_anae_12893 crossref_primary_10_7759_cureus_76418 crossref_primary_10_1007_s00423_019_01752_7 crossref_primary_10_1186_s13613_020_00659_7 crossref_primary_10_1016_j_jcrc_2017_05_036 crossref_primary_10_1097_CCM_0000000000001157 crossref_primary_10_1016_j_medine_2017_01_003 crossref_primary_10_1097_CCM_0000000000002244 crossref_primary_10_4103_0972_5229_160281 crossref_primary_10_1177_2050312119835043 crossref_primary_10_1183_13993003_01818_2017 crossref_primary_10_1038_ki_2014_211 crossref_primary_10_1155_2015_729075 crossref_primary_10_1016_j_ccc_2019_08_009 crossref_primary_10_1136_bmjopen_2024_094792 crossref_primary_10_3390_ph15121496 crossref_primary_10_1016_j_jemermed_2018_09_035 crossref_primary_10_1177_1060028019843664 crossref_primary_10_1186_s13017_017_0141_6 crossref_primary_10_1097_SHK_0000000000000555 crossref_primary_10_1016_j_bpa_2016_11_001 crossref_primary_10_1186_s13613_020_00711_6 crossref_primary_10_1016_j_semnephrol_2018_10_001 crossref_primary_10_1097_TA_0000000000000799 crossref_primary_10_1016_j_ccc_2017_12_004 crossref_primary_10_1097_01_NAJ_0000525851_44945_70 crossref_primary_10_1186_2110_5820_4_16 crossref_primary_10_1136_bmjopen_2025_101200 crossref_primary_10_1016_j_jcrc_2015_01_009 crossref_primary_10_1097_CCM_0000000000001142 crossref_primary_10_1513_AnnalsATS_201409_415OC crossref_primary_10_1186_s13054_016_1243_3 crossref_primary_10_1097_CCM_0000000000002235 crossref_primary_10_1186_s13104_018_3988_z crossref_primary_10_1002_jhm_2394 crossref_primary_10_1016_j_jcrc_2025_155269 crossref_primary_10_1177_0885066616663169 crossref_primary_10_1080_14787210_2018_1547192 crossref_primary_10_1097_JCMA_0000000000000911 crossref_primary_10_1016_j_ajem_2016_09_017 crossref_primary_10_1097_MD_0000000000002601 crossref_primary_10_1016_j_bjane_2018_04_009 crossref_primary_10_1016_j_jcrc_2017_05_024 crossref_primary_10_1182_blood_2023022385 crossref_primary_10_1053_j_semperi_2017_11_003 crossref_primary_10_1186_s12871_015_0005_0 crossref_primary_10_12688_f1000research_6565_1 crossref_primary_10_1007_s00063_015_0108_x crossref_primary_10_1016_S0140_6736_15_60733_4 crossref_primary_10_1016_j_intimp_2023_110083 crossref_primary_10_1371_journal_pcbi_1004314 crossref_primary_10_1016_j_amjms_2020_01_012 crossref_primary_10_1097_ACO_0000000000000303 crossref_primary_10_3390_ijms25115924 crossref_primary_10_2217_fmb_15_133 crossref_primary_10_1097_ACO_0000000000000305 crossref_primary_10_1186_s13054_020_2734_9 crossref_primary_10_1164_rccm_201509_1900ED crossref_primary_10_1186_s13054_016_1276_7 crossref_primary_10_3389_fmed_2022_997992 crossref_primary_10_1016_j_bja_2022_04_008 crossref_primary_10_1007_s00540_019_02683_9 crossref_primary_10_1016_j_gastre_2016_10_004 crossref_primary_10_1016_j_jemermed_2016_12_009 crossref_primary_10_1097_CCM_0000000000001179 crossref_primary_10_1177_2333721416638980 crossref_primary_10_1016_j_mayocp_2014_07_009 crossref_primary_10_1016_j_mpaic_2015_10_009 crossref_primary_10_1177_0885066620928299 crossref_primary_10_1016_j_kint_2020_04_020 crossref_primary_10_1016_S1553_7250_15_41063_3 crossref_primary_10_1016_j_bja_2017_11_090 crossref_primary_10_1016_j_kint_2019_08_023 crossref_primary_10_1016_j_medcle_2019_01_013 crossref_primary_10_1007_s00134_019_05858_w crossref_primary_10_1016_j_gastrohep_2015_09_019 crossref_primary_10_1016_j_amjms_2019_04_025 crossref_primary_10_1186_s40560_018_0319_3 crossref_primary_10_3390_geriatrics9020045 crossref_primary_10_1186_s13613_018_0364_z crossref_primary_10_1186_s13054_014_0481_5 crossref_primary_10_1177_0885066620973917 crossref_primary_10_1016_j_medine_2016_06_002 crossref_primary_10_1136_bmjoq_2023_002593 crossref_primary_10_1097_CCM_0000000000001164 crossref_primary_10_1126_scitranslmed_aab3719 crossref_primary_10_1016_j_jointm_2025_08_001 crossref_primary_10_1097_CCM_0000000000002257 crossref_primary_10_1056_NEJMc1406745 crossref_primary_10_1097_CCM_0000000000002255 crossref_primary_10_1111_imj_14199 crossref_primary_10_1186_s13063_016_1689_2 crossref_primary_10_1097_CCM_0000000000002254 crossref_primary_10_1007_s00134_017_4817_x crossref_primary_10_1016_j_jcrc_2014_07_012 crossref_primary_10_1007_s00134_017_4683_6 crossref_primary_10_3390_jcm11185332 crossref_primary_10_1016_j_mayocp_2015_02_002 crossref_primary_10_1097_SHK_0000000000000765 crossref_primary_10_1186_s13054_020_2756_3 crossref_primary_10_1186_s40560_015_0112_5 crossref_primary_10_1164_rccm_202007_2627ED crossref_primary_10_1016_j_ajic_2020_02_014 crossref_primary_10_1016_j_accpm_2020_04_004 crossref_primary_10_1186_s13063_024_07995_0 crossref_primary_10_1517_14740338_2016_1128411 crossref_primary_10_1016_j_medine_2017_02_003 crossref_primary_10_1097_CCM_0000000000001106 crossref_primary_10_1097_CCM_0000000000002436 crossref_primary_10_1186_s40560_019_0407_z crossref_primary_10_1016_j_ajem_2020_10_020 crossref_primary_10_1016_j_jcrc_2015_10_015 crossref_primary_10_1001_jama_2024_3917 crossref_primary_10_1016_j_jcrc_2015_10_017 crossref_primary_10_1053_j_tcam_2016_08_009 crossref_primary_10_1159_000525548 crossref_primary_10_1016_j_bpa_2016_04_007 crossref_primary_10_1016_j_jss_2022_05_034 crossref_primary_10_1371_journal_pone_0155767 crossref_primary_10_1055_s_0041_1733915 crossref_primary_10_1007_s12630_018_1172_5 crossref_primary_10_1016_j_accpm_2020_10_003 crossref_primary_10_1513_AnnalsATS_201702_180CME crossref_primary_10_1093_bja_aew067 crossref_primary_10_1002_ams2_914 crossref_primary_10_1016_j_semnephrol_2020_08_004 crossref_primary_10_1016_j_jemermed_2016_04_010 crossref_primary_10_1186_s12916_015_0335_2 crossref_primary_10_1016_j_jcrc_2017_06_028 crossref_primary_10_1186_s40635_017_0139_0 crossref_primary_10_1097_MD_0000000000008111 crossref_primary_10_1093_mmy_myv076 crossref_primary_10_1097_MD_0000000000022880 crossref_primary_10_1378_chest_14_1712 crossref_primary_10_1097_CCM_0000000000004845 crossref_primary_10_1186_cc13970 crossref_primary_10_1016_j_jcrc_2017_12_018 crossref_primary_10_1097_PCC_0000000000002029 crossref_primary_10_1007_s00268_022_06638_2 crossref_primary_10_1016_j_mpsur_2015_08_002 crossref_primary_10_1155_2016_6593232 crossref_primary_10_1177_10892532241249582 crossref_primary_10_1186_s13054_014_0702_y crossref_primary_10_3389_fped_2018_00002 crossref_primary_10_1016_j_mayocp_2015_01_022 crossref_primary_10_5114_aoms_172160 crossref_primary_10_1097_CCM_0000000000003762 crossref_primary_10_1038_s42003_019_0473_8 crossref_primary_10_1001_jamainternmed_2020_0180 crossref_primary_10_1007_s00134_016_4605_z crossref_primary_10_1007_s13546_015_1062_6 crossref_primary_10_3389_fped_2014_00056 crossref_primary_10_1513_AnnalsATS_202009_1130OC crossref_primary_10_1177_0310057X1504300109 crossref_primary_10_1186_s13054_014_0570_5 crossref_primary_10_1186_s13613_014_0021_0 crossref_primary_10_1007_s00134_016_4471_8 crossref_primary_10_1016_j_emc_2016_08_007 crossref_primary_10_1016_j_emc_2016_08_006 crossref_primary_10_1007_s13311_022_01315_7 crossref_primary_10_1016_j_emc_2016_08_004 crossref_primary_10_1016_j_emc_2016_08_002 crossref_primary_10_1016_j_emc_2016_08_001 crossref_primary_10_1056_NEJMc1413474 crossref_primary_10_1016_j_bja_2019_03_027 crossref_primary_10_1097_CCM_0000000000003791 crossref_primary_10_1007_s00134_015_3837_7 crossref_primary_10_1186_2197_425X_3_S1_A46 crossref_primary_10_1182_bloodadvances_2022007719 crossref_primary_10_1136_emermed_2019_209239 crossref_primary_10_1371_journal_pone_0281208 crossref_primary_10_1016_j_cpcardiol_2023_101805 crossref_primary_10_1186_s13613_017_0241_1 crossref_primary_10_1016_j_cjtee_2017_06_005 crossref_primary_10_1016_j_ajem_2025_04_060 crossref_primary_10_1016_j_suc_2023_05_011 crossref_primary_10_1186_s13054_019_2644_x crossref_primary_10_1097_CCM_0000000000002206 crossref_primary_10_1097_CCM_0000000000003779 crossref_primary_10_2147_OAEM_S289148 crossref_primary_10_3390_jpm14020149 crossref_primary_10_1097_CCM_0000000000002688 crossref_primary_10_1186_s12245_016_0106_7 crossref_primary_10_1007_s10877_014_9598_y crossref_primary_10_1186_s40360_016_0063_z crossref_primary_10_1093_infdis_jiaa247 crossref_primary_10_2196_15997 crossref_primary_10_1186_s12873_016_0095_0 crossref_primary_10_1186_s12893_025_03000_w crossref_primary_10_1097_CCM_0000000000001361 crossref_primary_10_1177_1357633X17691862 crossref_primary_10_1186_s13054_014_0496_y crossref_primary_10_1186_s13054_015_0936_3 crossref_primary_10_1186_s13613_021_00928_z crossref_primary_10_1016_j_medine_2017_02_006 crossref_primary_10_1097_CCM_0000000000003544 crossref_primary_10_1186_s12871_017_0316_4 crossref_primary_10_1681_ASN_2017010069 crossref_primary_10_1016_j_medine_2017_02_004 crossref_primary_10_1097_CCM_0000000000002211 crossref_primary_10_1016_j_medine_2014_12_001 crossref_primary_10_3389_fmed_2023_1042487 crossref_primary_10_1007_s10049_015_0094_9 crossref_primary_10_1016_j_ajem_2015_01_051 crossref_primary_10_1097_PTS_0000000000000923 crossref_primary_10_1515_med_2017_0059 crossref_primary_10_3390_jcm14093027 crossref_primary_10_1136_tsaco_2019_000411 crossref_primary_10_1111_cbdd_13039 crossref_primary_10_1097_CCM_0000000000003723 crossref_primary_10_3390_cells11182833 crossref_primary_10_1186_s40635_014_0036_8 crossref_primary_10_1016_j_annemergmed_2015_09_010 crossref_primary_10_1097_CCM_0000000000001308 crossref_primary_10_1111_crj_13218 crossref_primary_10_1213_ANE_0000000000002085 crossref_primary_10_1016_j_jcrc_2016_08_002 crossref_primary_10_1007_s00134_015_3783_4 crossref_primary_10_1186_s40560_019_0360_x crossref_primary_10_1371_journal_pone_0153305 crossref_primary_10_1016_j_resuscitation_2015_07_038 crossref_primary_10_1186_s13054_018_1959_3 crossref_primary_10_5492_wjccm_v13_i1_90176 crossref_primary_10_1001_jama_2019_5791 crossref_primary_10_3390_medicina58010026 crossref_primary_10_1177_0885066618784861 crossref_primary_10_1016_j_ccc_2023_12_003 crossref_primary_10_1097_JS9_0000000000002668 crossref_primary_10_1186_s12871_021_01553_w crossref_primary_10_1007_s00134_016_4675_y crossref_primary_10_1177_1357633X231170038 crossref_primary_10_3389_fmed_2020_517999 crossref_primary_10_1007_s00063_016_0162_z crossref_primary_10_1016_j_ccc_2014_08_006 crossref_primary_10_2217_cer_2020_0141 crossref_primary_10_1016_j_jcrc_2020_02_004 crossref_primary_10_1007_s15033_015_0139_2 crossref_primary_10_4037_ajcc2016564 crossref_primary_10_1097_SHK_0000000000000396 crossref_primary_10_1093_intqhc_mzad006 crossref_primary_10_1097_TA_0000000000001246 crossref_primary_10_1097_CCM_0000000000000443 crossref_primary_10_1097_SHK_0000000000002576 crossref_primary_10_1136_bmjopen_2015_008330 crossref_primary_10_1177_0310057X1604400104 crossref_primary_10_1186_s12967_018_1700_7 crossref_primary_10_1186_s13054_020_03241_6 crossref_primary_10_1097_CM9_0000000000000221 crossref_primary_10_1186_s13613_023_01178_x crossref_primary_10_1097_CCM_0000000000003960 crossref_primary_10_3892_etm_2017_4742 crossref_primary_10_1097_CCM_0000000000000693 crossref_primary_10_1186_s13054_014_0579_9 crossref_primary_10_1186_s13049_020_00745_6 crossref_primary_10_1016_j_bjan_2015_07_003 crossref_primary_10_1177_2049936119856517 crossref_primary_10_3390_ijms242216185 crossref_primary_10_1177_1060028014541792 crossref_primary_10_1007_s00063_013_0273_8 crossref_primary_10_1097_SHK_0000000000001239 crossref_primary_10_1007_s00101_020_00857_9 crossref_primary_10_1016_j_jcrc_2024_154985 crossref_primary_10_1111_jep_13881 crossref_primary_10_1097_CCM_0000000000003746 crossref_primary_10_1097_SHK_0000000000001474 crossref_primary_10_1097_CCM_0000000000003507 crossref_primary_10_1016_j_jcrc_2016_09_030 crossref_primary_10_1097_CCM_0000000000004842 crossref_primary_10_1177_1062860618796947 crossref_primary_10_1097_CCM_0000000000001572 crossref_primary_10_1080_07853890_2017_1332776 crossref_primary_10_1016_j_annemergmed_2016_04_056 crossref_primary_10_1016_j_jcrc_2016_09_031 crossref_primary_10_1016_j_mpsur_2015_07_019 crossref_primary_10_1016_j_resuscitation_2015_07_018 crossref_primary_10_1007_s00134_016_4444_y crossref_primary_10_1016_j_ajem_2018_01_060 crossref_primary_10_1097_ACO_0000000000000959 crossref_primary_10_1136_tsaco_2017_000088 crossref_primary_10_1097_CCM_0000000000002409 crossref_primary_10_1097_SHK_0000000000002559 crossref_primary_10_2478_prilozi_2018_0024 crossref_primary_10_1038_s41598_021_01856_5 crossref_primary_10_1055_s_0041_1736382 crossref_primary_10_1001_jamanetworkopen_2022_51453 crossref_primary_10_1016_j_ajem_2015_10_039 crossref_primary_10_1016_j_jcrc_2016_08_010 crossref_primary_10_4187_respcare_06015 crossref_primary_10_1007_s11739_015_1371_9 crossref_primary_10_1002_ams2_322 crossref_primary_10_1586_14787210_2016_1135052 crossref_primary_10_1016_j_drudis_2018_01_015 crossref_primary_10_1097_AIA_0000000000000219 crossref_primary_10_1016_j_ajem_2018_01_078 crossref_primary_10_1177_0391398820917150 crossref_primary_10_1136_bmjquality_u210706_w4335 crossref_primary_10_1186_s12873_015_0057_y crossref_primary_10_1186_s40560_017_0210_7 crossref_primary_10_1080_07853890_2021_1987511 crossref_primary_10_1080_10903127_2019_1629134 crossref_primary_10_1371_journal_pone_0182351 crossref_primary_10_1007_s00134_015_3928_5 crossref_primary_10_1016_j_ajic_2017_04_005 crossref_primary_10_1007_s00134_015_3906_y crossref_primary_10_1016_j_chest_2020_03_029 crossref_primary_10_1056_NEJMoa1701380 crossref_primary_10_3390_medicina60050751 crossref_primary_10_1097_CCM_0000000000001505 crossref_primary_10_3390_jcm10030527 crossref_primary_10_1007_s10049_014_1962_4 crossref_primary_10_1097_CCM_0000000000002834 crossref_primary_10_63096_medtigo3092112 crossref_primary_10_1001_jama_2019_14607 crossref_primary_10_1097_CCE_0000000000001015 crossref_primary_10_1016_j_jtct_2023_12_013 crossref_primary_10_1097_CCM_0000000000001990 crossref_primary_10_1002_jhm_2347 crossref_primary_10_1007_s40140_015_0124_7 crossref_primary_10_1016_j_chest_2020_10_078 crossref_primary_10_1016_j_suc_2017_07_003 crossref_primary_10_1097_SHK_0000000000001209 crossref_primary_10_1111_aas_12848 crossref_primary_10_1016_j_jcrc_2015_12_010 crossref_primary_10_1016_j_bjan_2018_04_001 crossref_primary_10_1016_j_jcrc_2014_04_011 crossref_primary_10_1097_MCC_0000000000000834 crossref_primary_10_1097_SHK_0000000000001442 crossref_primary_10_1097_CCM_0000000000002824 crossref_primary_10_1016_j_jcrc_2018_02_012 crossref_primary_10_1093_ofid_ofab321 crossref_primary_10_1186_s13613_014_0030_z crossref_primary_10_1093_cid_ciaa059 crossref_primary_10_1164_rccm_202209_1831CI crossref_primary_10_3390_jcm7090247 crossref_primary_10_1136_bmjopen_2023_074847 crossref_primary_10_1016_j_ajog_2019_01_216 crossref_primary_10_1001_jamainternmed_2020_2756 crossref_primary_10_1164_rccm_202303_0521ED crossref_primary_10_1016_j_medine_2022_03_007 crossref_primary_10_1097_CCM_0000000000002610 crossref_primary_10_1186_s13054_018_2173_z crossref_primary_10_1007_s11908_015_0493_6 crossref_primary_10_1186_s13613_019_0545_4 crossref_primary_10_1097_CM9_0000000000000887 crossref_primary_10_1097_CCM_0000000000003703 crossref_primary_10_1186_s12871_020_00987_y crossref_primary_10_1186_s13054_015_0921_x crossref_primary_10_1007_s11739_017_1607_y crossref_primary_10_1177_0885066616689548 crossref_primary_10_1111_1742_6723_14168 crossref_primary_10_1177_102490791502200305 crossref_primary_10_1016_j_medin_2016_10_015 crossref_primary_10_1177_0885066616686035 crossref_primary_10_1007_s12630_016_0803_y crossref_primary_10_1186_s12879_016_1896_1 crossref_primary_10_1128_IAI_00031_20 crossref_primary_10_1186_s13054_015_0989_3 crossref_primary_10_1056_NEJMc1506514 crossref_primary_10_1007_s13546_014_1015_5 crossref_primary_10_1164_rccm_201412_2297LE crossref_primary_10_1097_CCM_0000000000001997 crossref_primary_10_1007_s00101_021_00953_4 crossref_primary_10_1007_s00101_015_0035_5 crossref_primary_10_4103_0972_5229_160275 crossref_primary_10_1097_01_JAA_0000453869_69947_10 crossref_primary_10_1097_AIA_0000000000000416 crossref_primary_10_1097_CCM_0000000000002851 crossref_primary_10_1016_j_cct_2015_11_003 crossref_primary_10_1097_PCC_0000000000000263 crossref_primary_10_1080_00325481_2015_1022494 crossref_primary_10_1111_sdi_12669 crossref_primary_10_1371_journal_pone_0225700 crossref_primary_10_3390_microorganisms11051119 crossref_primary_10_1177_102490791702400302 crossref_primary_10_1056_NEJMoa1406617 crossref_primary_10_1186_s13054_015_0970_1 crossref_primary_10_1007_s40124_014_0073_5 crossref_primary_10_1182_bloodadvances_2020002504 crossref_primary_10_1016_j_accpm_2017_07_004 crossref_primary_10_1586_14787210_2016_1154787 crossref_primary_10_1097_MEJ_0000000000000460 crossref_primary_10_1016_j_ajem_2018_10_047 crossref_primary_10_1016_S0140_6736_17_31329_6 crossref_primary_10_1016_j_ccc_2017_08_009 crossref_primary_10_1016_j_jemermed_2018_05_031 crossref_primary_10_1016_j_jemermed_2022_06_002 crossref_primary_10_1097_NUR_0000000000000532 crossref_primary_10_1007_s11910_016_0623_z crossref_primary_10_1097_CCE_0000000000000767 crossref_primary_10_1164_rccm_201502_0307UP crossref_primary_10_5847_wjem_j_1920_8642_2015_04_001 crossref_primary_10_1016_j_ccc_2017_08_003 crossref_primary_10_3390_jcdd10050208 crossref_primary_10_1016_j_annemergmed_2018_06_046 crossref_primary_10_1001_jamainternmed_2021_2626 crossref_primary_10_1007_s00063_015_0124_x crossref_primary_10_1016_j_ccc_2017_08_005 crossref_primary_10_1089_sur_2019_126 crossref_primary_10_1186_s40697_016_0098_5 crossref_primary_10_1093_biostatistics_kxaf023 crossref_primary_10_1097_CCM_0000000000001938 crossref_primary_10_1016_j_jclinane_2016_08_031 crossref_primary_10_1186_s40635_022_00433_y crossref_primary_10_1002_j_2040_4603_2021_tb00162_x crossref_primary_10_3390_jcm11247277 crossref_primary_10_1186_s13054_014_0609_7 crossref_primary_10_7326_M14_2611 crossref_primary_10_1007_s00108_017_0338_5 crossref_primary_10_1097_EC9_0000000000000033 crossref_primary_10_1016_j_amjms_2018_06_012 crossref_primary_10_1159_000507999 crossref_primary_10_1007_s10877_022_00946_7 crossref_primary_10_1097_SHK_0000000000002176 crossref_primary_10_1186_s13054_018_2186_7 crossref_primary_10_1186_s40560_025_00801_2 crossref_primary_10_1097_CCM_0000000000006398 crossref_primary_10_1186_s13054_014_0707_6 crossref_primary_10_2146_ajhp150220 crossref_primary_10_1186_s13049_021_00958_3 crossref_primary_10_1136_emermed_2017_207245 crossref_primary_10_3109_00365513_2014_965736 crossref_primary_10_1371_journal_pone_0185320 crossref_primary_10_1002_ams2_70037 crossref_primary_10_1093_intqhc_mzy077 crossref_primary_10_1097_CCM_0000000000005061 crossref_primary_10_1053_j_jvca_2014_07_005 crossref_primary_10_1111_tog_12623 crossref_primary_10_4103_0366_6999_202734 crossref_primary_10_1016_S2213_2600_17_30213_8 crossref_primary_10_1016_j_jcrc_2015_04_003 crossref_primary_10_1097_PCC_0000000000000507 crossref_primary_10_1016_j_semnephrol_2015_01_006 crossref_primary_10_1016_j_chest_2020_08_2068 crossref_primary_10_1053_j_jvca_2014_07_009 crossref_primary_10_1097_MCC_0000000000000725 crossref_primary_10_1186_s13054_020_03109_9 crossref_primary_10_1007_s00134_020_05950_6 crossref_primary_10_1186_s13054_014_0697_4 crossref_primary_10_1186_s40560_016_0151_6 crossref_primary_10_1016_j_semnephrol_2015_01_003 crossref_primary_10_1016_j_tjem_2017_11_002 crossref_primary_10_1016_j_idc_2017_05_001 crossref_primary_10_1177_2333392820920082 crossref_primary_10_5005_jp_journals_10071_23262 crossref_primary_10_1038_ki_2015_26 crossref_primary_10_1007_s43678_022_00431_9 crossref_primary_10_1136_bcr_2015_210185 crossref_primary_10_1136_emermed_2020_209771 crossref_primary_10_1016_j_ajem_2017_01_061 crossref_primary_10_1177_1062860614551042 crossref_primary_10_1177_0885066616671689 crossref_primary_10_1007_s10877_017_0032_0 crossref_primary_10_1007_s11010_020_04019_8 crossref_primary_10_1016_j_ajem_2020_08_058 crossref_primary_10_2174_1381612826666200909124936 crossref_primary_10_1007_s00101_020_00849_9 crossref_primary_10_3390_jcm11237231 crossref_primary_10_1186_s12871_024_02662_y crossref_primary_10_1186_s13741_015_0024_x crossref_primary_10_1177_0885066619855000 crossref_primary_10_1177_2050313X17741013 crossref_primary_10_1007_s00134_018_5415_2 crossref_primary_10_1136_bmjopen_2025_104257 crossref_primary_10_3390_jpm11020157 crossref_primary_10_1097_MD_0000000000018519 crossref_primary_10_1097_CCE_0000000000000312 crossref_primary_10_1177_1062860615606801 crossref_primary_10_1007_s00063_015_0111_2 crossref_primary_10_4103_JTCCM_D_22_00016 crossref_primary_10_4103_JTCCM_D_22_00015 crossref_primary_10_1097_MD_0000000000025483 crossref_primary_10_1016_j_ajem_2019_02_007 crossref_primary_10_1097_MD_0000000000002124 crossref_primary_10_1016_j_emc_2016_04_005 crossref_primary_10_1111_nep_13500 crossref_primary_10_1097_MCC_0000000000000300 crossref_primary_10_1016_j_ajem_2015_10_007 crossref_primary_10_1016_j_ajem_2015_10_006 crossref_primary_10_1016_j_chstcc_2023_100043 crossref_primary_10_1016_j_medin_2022_02_010 crossref_primary_10_1080_14728222_2021_1897107 crossref_primary_10_1097_MCC_0000000000000551 crossref_primary_10_1111_sdi_12352 crossref_primary_10_1186_s13054_018_2240_5 crossref_primary_10_1016_j_ejphar_2017_05_012 crossref_primary_10_1093_ofid_ofx213 crossref_primary_10_1186_s13054_016_1421_3 crossref_primary_10_1097_MEJ_0000000000000419 crossref_primary_10_1371_journal_pone_0186687 crossref_primary_10_1007_s13546_015_1036_8 crossref_primary_10_1007_s00101_014_2344_5 crossref_primary_10_1016_j_annemergmed_2018_04_002 crossref_primary_10_1097_MEJ_0000000000000435 crossref_primary_10_1016_j_medine_2017_06_008 crossref_primary_10_1007_s00101_023_01354_5 crossref_primary_10_3389_fphys_2022_992401 crossref_primary_10_1007_s00134_017_4755_7 crossref_primary_10_1164_rccm_201701_0164UP crossref_primary_10_3389_fmed_2022_1069782 crossref_primary_10_1016_j_kint_2019_05_026 crossref_primary_10_1016_j_medine_2022_02_025 crossref_primary_10_1007_s00134_015_3961_4 crossref_primary_10_1016_j_medine_2022_02_026 crossref_primary_10_1177_1751143718754995 crossref_primary_10_4037_ajcc2017609 crossref_primary_10_1093_tropej_fmaa025 crossref_primary_10_1001_jama_2019_9021 crossref_primary_10_1097_SHK_0000000000001281 crossref_primary_10_1136_emermed_2017_207285 crossref_primary_10_1016_j_jcrc_2020_07_011 crossref_primary_10_1016_j_emc_2016_09_001 crossref_primary_10_1016_j_annemergmed_2016_02_044 crossref_primary_10_1016_S1473_3099_14_71003_5 crossref_primary_10_62675_2965_2774_20250130 crossref_primary_10_1186_s12911_016_0396_y crossref_primary_10_1016_j_emc_2016_09_008 crossref_primary_10_1371_journal_pone_0190952 crossref_primary_10_1016_j_jss_2015_04_075 crossref_primary_10_1097_SHK_0000000000002120 crossref_primary_10_1016_j_ajem_2020_08_021 crossref_primary_10_1161_JAHA_118_009160 crossref_primary_10_1097_PCC_0000000000000796 crossref_primary_10_1136_eb_2014_101903 crossref_primary_10_1016_j_jemermed_2016_01_036 crossref_primary_10_1177_1751143714564826 crossref_primary_10_1007_s00101_017_0339_8 crossref_primary_10_1016_j_jcrc_2017_07_028 crossref_primary_10_1186_s13613_018_0449_8 crossref_primary_10_1016_j_emc_2020_06_006 crossref_primary_10_5694_mja2_50338 crossref_primary_10_1080_14787210_2020_1810567 crossref_primary_10_1007_s11739_014_1151_y crossref_primary_10_1111_aas_13455 crossref_primary_10_1371_journal_pone_0188882 crossref_primary_10_1007_s00063_015_0011_5 crossref_primary_10_1016_j_cnc_2015_05_001 crossref_primary_10_1016_j_bios_2017_09_032 crossref_primary_10_1016_j_medin_2022_02_003 crossref_primary_10_3390_jcm12154950 crossref_primary_10_1016_j_ajem_2016_06_012 crossref_primary_10_1097_PCC_0000000000000779 crossref_primary_10_1186_s13054_021_03682_7 crossref_primary_10_1007_s40140_019_00330_3 crossref_primary_10_1016_j_ajem_2015_12_068 crossref_primary_10_7717_peerj_1290 crossref_primary_10_1016_j_ccc_2024_01_004 crossref_primary_10_1097_CCM_0000000000006135 crossref_primary_10_4103_2452_2473_367400 crossref_primary_10_1164_rccm_201812_2342OC crossref_primary_10_1186_s13054_014_0533_x crossref_primary_10_1007_s00134_021_06506_y crossref_primary_10_1016_j_jcrc_2015_03_011 crossref_primary_10_1097_CRD_0000000000000301 crossref_primary_10_1007_s00134_017_4681_8 crossref_primary_10_1016_j_ajem_2022_08_008 crossref_primary_10_1371_journal_pone_0252629 crossref_primary_10_1186_s13613_017_0292_3 crossref_primary_10_3390_healthcare13182264 crossref_primary_10_1155_2016_3948795 crossref_primary_10_1097_MCC_0000000000000344 crossref_primary_10_1186_s13054_020_2732_y crossref_primary_10_1186_s40560_019_0367_3 crossref_primary_10_1177_0885066617701904 crossref_primary_10_1093_ofid_ofaf337 crossref_primary_10_4037_ajcc2024756 crossref_primary_10_1097_MCC_0000000000000348 crossref_primary_10_1097_MD_0000000000010866 crossref_primary_10_1016_j_jemermed_2016_03_021 crossref_primary_10_3389_fmed_2017_00020 crossref_primary_10_3390_life14101257 crossref_primary_10_1007_s00063_023_01028_5 crossref_primary_10_1007_s11739_023_03265_0 crossref_primary_10_1097_MCC_0000000000001201 crossref_primary_10_1007_s12028_023_01871_6 crossref_primary_10_1016_j_chest_2022_08_2240 crossref_primary_10_1111_voxs_12251 crossref_primary_10_1007_s13341_014_0461_z crossref_primary_10_1016_j_tice_2025_102849 crossref_primary_10_1016_j_ajem_2016_07_031 crossref_primary_10_1093_bja_aev295 crossref_primary_10_1186_s13054_023_04755_5 crossref_primary_10_1097_CNQ_0000000000000052 crossref_primary_10_1097_CNQ_0000000000000053 crossref_primary_10_1007_s11739_025_03877_8 crossref_primary_10_1055_s_0040_1713083 crossref_primary_10_1097_MCC_0000000000000116 crossref_primary_10_2460_ajvr_78_2_230 crossref_primary_10_1016_j_mpaic_2023_09_017 crossref_primary_10_1093_cid_cix548 crossref_primary_10_3389_fmed_2022_839284 crossref_primary_10_1007_s00134_015_3952_5 crossref_primary_10_1186_s13054_016_1476_1 crossref_primary_10_1016_j_ijans_2023_100601 crossref_primary_10_1016_j_ajem_2022_09_038 crossref_primary_10_1016_j_jemermed_2018_07_033 crossref_primary_10_1016_j_ccc_2015_06_003 crossref_primary_10_3390_medicina59061047 crossref_primary_10_1016_j_ajem_2014_07_024 crossref_primary_10_1016_j_ajem_2014_07_023 crossref_primary_10_5847_wjem_j_1920_8642_2015_02_004 crossref_primary_10_1007_s00101_017_0363_8 crossref_primary_10_1093_burnst_tkz006 crossref_primary_10_1016_S2213_2600_14_70205_X crossref_primary_10_1159_000478973 crossref_primary_10_1097_MEJ_0000000000000403 crossref_primary_10_1007_s40124_016_0093_4 crossref_primary_10_1097_PCC_0000000000000906 crossref_primary_10_1164_rccm_201502_0275OC crossref_primary_10_5847_wjem_j_1920_8642_2024_025 crossref_primary_10_1007_s00108_024_01794_0 crossref_primary_10_1177_000313481708301125 crossref_primary_10_1097_CCM_0000000000006348 crossref_primary_10_7326_M19_1696 crossref_primary_10_1007_s00134_014_3568_1 crossref_primary_10_1016_j_chest_2018_04_043 crossref_primary_10_1016_j_ccc_2014_12_007 crossref_primary_10_1007_s00063_016_0145_0 crossref_primary_10_1055_s_0041_1733899 crossref_primary_10_1016_j_ccc_2015_06_012 crossref_primary_10_1055_s_0041_1733898 crossref_primary_10_1053_j_jvca_2023_02_011 crossref_primary_10_1111_1742_6723_12621 crossref_primary_10_1055_s_0041_1733897 crossref_primary_10_1007_s00101_017_0396_z crossref_primary_10_1213_ANE_0000000000001340 crossref_primary_10_1186_s40635_016_0112_3 crossref_primary_10_1213_ANE_0000000000001585 crossref_primary_10_1097_MEJ_0000000000000893 crossref_primary_10_14423_SMJ_0000000000000727 crossref_primary_10_1371_journal_pone_0217857 crossref_primary_10_1186_s12871_018_0669_3 crossref_primary_10_1097_ACO_0000000000000157 crossref_primary_10_1097_MCC_0000000000000335 crossref_primary_10_1007_s00011_017_1066_y crossref_primary_10_1186_s13049_016_0197_4 crossref_primary_10_1056_NEJMoa1500896 crossref_primary_10_1097_CCM_0000000000005247 crossref_primary_10_1186_s13613_014_0038_4 crossref_primary_10_3934_bdia_2024002 crossref_primary_10_35401_2541_9897_2025_10_3_127_135 crossref_primary_10_1186_s12245_015_0068_1 crossref_primary_10_1093_bja_aev284 crossref_primary_10_1186_2046_7648_3_16 crossref_primary_10_1097_GCO_0000000000000250 crossref_primary_10_1186_s40001_025_02760_8 crossref_primary_10_3390_jpm12111803 crossref_primary_10_1016_j_medin_2014_12_006 crossref_primary_10_1093_ajhp_zxaa178 crossref_primary_10_1007_s00134_015_3943_6 crossref_primary_10_1136_archdischild_2020_320078 crossref_primary_10_3389_fmed_2015_00044 crossref_primary_10_1016_S1473_3099_15_70147_7 crossref_primary_10_1016_j_ajem_2016_08_031 crossref_primary_10_1186_s13054_015_1057_8 crossref_primary_10_1016_j_yasu_2016_04_002 crossref_primary_10_1177_0310057X1704500106 crossref_primary_10_1177_1751143716683713 crossref_primary_10_1007_s00063_020_00685_0 crossref_primary_10_1136_bmjqs_2014_003552 crossref_primary_10_1016_j_annemergmed_2018_03_039 crossref_primary_10_1097_MCC_0000000000000154 crossref_primary_10_1007_s10049_023_01195_0 crossref_primary_10_1097_CCM_0000000000004342 crossref_primary_10_1016_j_mpsur_2015_01_009 crossref_primary_10_1097_CCE_0000000000000964 crossref_primary_10_1002_hep_30412 crossref_primary_10_1007_s00134_014_3526_y crossref_primary_10_1097_CNQ_0000000000000091 crossref_primary_10_1111_1742_6723_12400 crossref_primary_10_1007_s00134_015_3680_x crossref_primary_10_1097_CNQ_0000000000000093 crossref_primary_10_1007_s00134_016_4295_6 crossref_primary_10_1007_s13346_018_0573_x crossref_primary_10_1017_cem_2016_351 crossref_primary_10_1007_s00101_016_0188_x crossref_primary_10_1007_s12098_022_04434_3 crossref_primary_10_1038_s41598_023_49219_6 crossref_primary_10_1097_ACO_0000000000000339 crossref_primary_10_1097_CCM_0000000000004568 crossref_primary_10_1186_s13054_023_04644_x crossref_primary_10_1097_CCM_0000000000004578 crossref_primary_10_1186_s13054_015_1011_9 crossref_primary_10_1007_s00540_017_2312_8 crossref_primary_10_1186_s13054_014_0705_8 crossref_primary_10_1038_s41598_020_74906_z crossref_primary_10_1016_j_annemergmed_2015_06_016 crossref_primary_10_1136_bmjopen_2014_006524 crossref_primary_10_1097_JPN_0000000000000159 crossref_primary_10_1007_s00134_017_4724_1 crossref_primary_10_1007_s12325_022_02280_5 crossref_primary_10_1016_j_clinthera_2016_12_003 crossref_primary_10_1186_s13054_017_1662_9 crossref_primary_10_1007_s13546_015_1043_9 crossref_primary_10_1093_bja_aew110 crossref_primary_10_1016_j_jemermed_2015_09_007 crossref_primary_10_1053_j_ajkd_2016_04_020 crossref_primary_10_1186_s13054_020_2819_5 crossref_primary_10_1371_journal_pone_0137721 crossref_primary_10_1001_jamanetworkopen_2022_35331 crossref_primary_10_1007_s00134_017_4746_8 crossref_primary_10_1213_ANE_0000000000002620 crossref_primary_10_1016_j_ccm_2022_05_003 crossref_primary_10_3390_ijms18091946 crossref_primary_10_1016_j_jcrc_2017_04_005 crossref_primary_10_1111_codi_14432 crossref_primary_10_1213_ANE_0000000000001773 crossref_primary_10_1016_j_soin_2018_06_006 crossref_primary_10_1371_journal_pone_0144215 crossref_primary_10_1007_s00101_015_0050_6 crossref_primary_10_1016_S1473_3099_15_70112_X crossref_primary_10_2478_jccm_2025_0002 crossref_primary_10_1016_j_jinf_2025_106565 crossref_primary_10_1016_j_mcna_2022_08_006 crossref_primary_10_1097_PCC_0000000000000942 crossref_primary_10_1038_s41598_017_09433_5 crossref_primary_10_1097_CCM_0000000000005213 crossref_primary_10_1097_MCC_0000000000000372 crossref_primary_10_1097_CCM_0000000000002184 crossref_primary_10_1186_s13256_016_1191_1 crossref_primary_10_1097_CCM_0000000000001099 crossref_primary_10_1136_bmjopen_2020_038349 crossref_primary_10_1089_ars_2020_8149 crossref_primary_10_1159_000528633 crossref_primary_10_1097_CCM_0000000000003030 crossref_primary_10_1111_vec_12465 crossref_primary_10_1007_s00134_024_07509_1 crossref_primary_10_1177_0310057X1504300613 crossref_primary_10_1186_s13063_023_07275_3 crossref_primary_10_1186_s40635_024_00684_x crossref_primary_10_1097_CCM_0000000000006769 crossref_primary_10_3390_medicina59030597 crossref_primary_10_1007_s00134_019_05878_6 crossref_primary_10_1016_j_bpa_2017_08_008 crossref_primary_10_1016_j_ajem_2018_10_058 crossref_primary_10_1016_j_ekir_2017_03_015 crossref_primary_10_1097_CCM_0000000000001087 crossref_primary_10_1097_CCM_0000000000005203 crossref_primary_10_1111_apt_17458 crossref_primary_10_3389_fvets_2021_625708 crossref_primary_10_1007_s11894_015_0437_1 crossref_primary_10_1111_jan_15771 crossref_primary_10_1007_s10049_015_0098_5 crossref_primary_10_1093_bja_aew333 crossref_primary_10_1136_bmjopen_2024_098304 crossref_primary_10_1371_journal_pntd_0005603 crossref_primary_10_1097_TA_0000000000001904 crossref_primary_10_3390_biomedicines10112845 crossref_primary_10_1097_ACO_0000000000000407 crossref_primary_10_1007_s10877_015_9817_1 crossref_primary_10_1007_s00134_020_05934_6 crossref_primary_10_1016_j_gheart_2014_08_003 crossref_primary_10_1213_ANE_0000000000001278 crossref_primary_10_1097_CCM_0000000000004539 crossref_primary_10_1136_bmjopen_2017_020068 crossref_primary_10_1016_j_gheart_2014_08_008 crossref_primary_10_1016_j_lpm_2016_03_005 crossref_primary_10_1016_j_annemergmed_2017_08_057 crossref_primary_10_1093_eurheartj_ehaf340 crossref_primary_10_1016_j_medin_2016_07_010 crossref_primary_10_1016_j_mpaic_2015_09_012 crossref_primary_10_7759_cureus_74358 crossref_primary_10_1186_s13049_016_0214_7 crossref_primary_10_1016_j_ijcard_2023_131144 crossref_primary_10_1038_s41598_024_55667_5 crossref_primary_10_1097_MPA_0000000000001716 crossref_primary_10_1007_s00063_021_00878_1 crossref_primary_10_1164_rccm_201503_0594ED crossref_primary_10_1016_j_ajem_2015_07_034 crossref_primary_10_1097_01_NAJ_0000544139_63510_b5 crossref_primary_10_2147_OAEM_S363520 crossref_primary_10_1007_s40615_016_0271_7 crossref_primary_10_1186_s13054_022_03917_1 crossref_primary_10_1186_s13054_015_0859_z crossref_primary_10_3390_jcm14155323 crossref_primary_10_1371_journal_pone_0269471 crossref_primary_10_1001_jama_2021_11119 crossref_primary_10_1177_08971900211000218 crossref_primary_10_3389_fped_2016_00021 crossref_primary_10_1186_s40635_015_0049_y crossref_primary_10_5483_BMBRep_2015_48_6_202 crossref_primary_10_1097_CCM_0000000000001020 crossref_primary_10_1097_CCM_0000000000002110 crossref_primary_10_1177_1753465815585716 crossref_primary_10_1186_s13049_017_0437_2 crossref_primary_10_1186_s13054_015_1010_x crossref_primary_10_1007_s00134_019_05670_6 crossref_primary_10_1016_j_ajem_2016_01_017 crossref_primary_10_1016_j_jemermed_2018_01_027 crossref_primary_10_1186_s13049_018_0527_9 crossref_primary_10_1016_j_anclin_2016_06_005 crossref_primary_10_1016_j_jcrc_2016_11_036 crossref_primary_10_1097_CCE_0000000000001189 crossref_primary_10_1186_s40560_017_0215_2 crossref_primary_10_1016_j_bpa_2014_07_005 crossref_primary_10_1186_s13613_015_0071_y crossref_primary_10_1016_j_mpaic_2016_03_005 crossref_primary_10_3390_diagnostics11101881 crossref_primary_10_1097_SHK_0000000000000667 crossref_primary_10_1016_j_amjsurg_2016_01_012 crossref_primary_10_1164_rccm_202108_1845ST crossref_primary_10_1186_s40635_024_00650_7 crossref_primary_10_1371_journal_pone_0237613 crossref_primary_10_1007_s00134_017_4729_9 crossref_primary_10_1186_s12879_021_06852_8 crossref_primary_10_1093_ndt_gfv285 crossref_primary_10_1164_rccm_201906_1197OC crossref_primary_10_1136_tsaco_2022_001024 crossref_primary_10_1186_s13054_023_04309_9 crossref_primary_10_1016_S2213_2600_14_70246_2 crossref_primary_10_1186_s13049_017_0370_4 crossref_primary_10_1097_CCM_0000000000001058 crossref_primary_10_1177_0885066617742832 crossref_primary_10_1016_j_jss_2021_03_003 crossref_primary_10_1097_MCC_0000000000000298 crossref_primary_10_2215_CJN_07250715 crossref_primary_10_1002_14651858_CD006632_pub3 crossref_primary_10_1186_s13054_014_0734_3 crossref_primary_10_1016_j_bpa_2015_01_004 crossref_primary_10_1016_j_mpaic_2022_02_020 crossref_primary_10_1164_rccm_201701_0165CP crossref_primary_10_5811_westjem_2018_11_39290 crossref_primary_10_1186_s12879_016_1620_1 crossref_primary_10_1016_j_jcrc_2015_09_034 crossref_primary_10_1177_000313481508101032 crossref_primary_10_1186_s12879_016_1882_7 crossref_primary_10_1016_j_ajem_2016_10_055 crossref_primary_10_1136_bmjopen_2016_013465 crossref_primary_10_1002_aet2_10123 crossref_primary_10_1007_s00134_018_5345_z crossref_primary_10_1016_j_intimp_2015_11_028 crossref_primary_10_1016_j_chest_2016_03_044 crossref_primary_10_1056_NEJMc1808731 crossref_primary_10_4254_wjh_v15_i4_497 crossref_primary_10_3390_jcm7120536 crossref_primary_10_1097_CCM_0000000000005877 crossref_primary_10_1097_SHK_0000000000000893 crossref_primary_10_1164_rccm_202209_1823ED crossref_primary_10_4037_ajcc2021632 crossref_primary_10_1097_CCM_0000000000005885 crossref_primary_10_1097_MOP_0000000000000222 crossref_primary_10_1007_s10877_016_9918_5 crossref_primary_10_1097_MOP_0000000000000221 crossref_primary_10_1089_tmj_2022_0369 crossref_primary_10_1097_PCC_0000000000000188 crossref_primary_10_1016_j_ccc_2015_08_010 crossref_primary_10_1097_CCM_0000000000002377 crossref_primary_10_1186_s13054_016_1288_3 crossref_primary_10_5527_wjn_v7_i1_1 crossref_primary_10_1097_CCM_0000000000004310 crossref_primary_10_1016_j_bbadis_2017_04_019 crossref_primary_10_1186_s13049_017_0415_8 crossref_primary_10_1007_s00134_015_3801_6 crossref_primary_10_1186_s13054_019_2543_1 crossref_primary_10_21303_2504_5679_2021_001622 crossref_primary_10_1097_PCC_0000000000000180 crossref_primary_10_3390_biomedicines11071836 crossref_primary_10_1093_jbcr_iraa214 crossref_primary_10_1186_s13643_019_1046_0 crossref_primary_10_1093_burnst_tkae073 crossref_primary_10_1016_j_amjmed_2019_09_012 crossref_primary_10_1136_bmjoq_2021_001624 crossref_primary_10_1016_j_jcrc_2016_10_019 crossref_primary_10_1136_heartjnl_2020_316889 crossref_primary_10_1371_journal_pone_0204509 crossref_primary_10_3390_jcm10143164 crossref_primary_10_1007_s00134_014_3570_7 crossref_primary_10_1097_AS9_0000000000000429 crossref_primary_10_1186_s40560_019_0361_9 crossref_primary_10_1017_ice_2018_154 crossref_primary_10_1136_jim_2020_001685 crossref_primary_10_1007_s12181_016_0060_x crossref_primary_10_1093_infdis_jiaa133 crossref_primary_10_1111_tme_12505 crossref_primary_10_1186_s13054_019_2534_2 crossref_primary_10_1016_j_bjane_2017_03_002 crossref_primary_10_1016_j_jcrc_2018_07_009 crossref_primary_10_1038_s41598_017_01107_6 crossref_primary_10_1111_vec_12749 crossref_primary_10_1128_microbiolspec_UTI_0003_2012 crossref_primary_10_1016_j_jen_2014_12_015 crossref_primary_10_1371_journal_pone_0281549 crossref_primary_10_1007_s13312_021_2392_2 crossref_primary_10_1136_bmjhci_2019_100109 crossref_primary_10_1186_s13613_017_0240_2 crossref_primary_10_1016_j_ajem_2016_10_075 crossref_primary_10_1016_j_jcrc_2018_08_035 crossref_primary_10_1186_s13054_017_1617_1 crossref_primary_10_1177_08850666211061472 crossref_primary_10_7759_cureus_10980 crossref_primary_10_1016_j_annemergmed_2015_05_025 crossref_primary_10_1016_j_ajog_2023_05_019 crossref_primary_10_1007_s40719_015_0022_y crossref_primary_10_1056_NEJMclde1705277 crossref_primary_10_1136_emermed_2015_205261 crossref_primary_10_3390_jcm7120554 crossref_primary_10_1007_s00134_015_3760_y crossref_primary_10_1056_NEJMra2403213 crossref_primary_10_1186_s12916_024_03715_2 crossref_primary_10_1016_j_jcrc_2025_155188 crossref_primary_10_1007_s00108_020_00861_6 crossref_primary_10_1097_CCM_0000000000002554 crossref_primary_10_1097_CCM_0000000000002311 crossref_primary_10_1186_s12916_020_01875_5 crossref_primary_10_1186_cc14706 crossref_primary_10_1186_s12916_015_0312_9 crossref_primary_10_3389_fmolb_2025_1603392 crossref_primary_10_1016_j_redare_2015_11_003 crossref_primary_10_1186_s40560_017_0270_8 crossref_primary_10_1016_j_compbiomed_2016_05_003 crossref_primary_10_1186_s13017_024_00551_w crossref_primary_10_3390_jcm10081693 crossref_primary_10_1186_s13054_015_0826_8 crossref_primary_10_1007_s12630_014_0265_z crossref_primary_10_1016_j_jff_2024_106272 crossref_primary_10_1089_jmf_2019_4476 crossref_primary_10_1097_CCM_0000000000005609 crossref_primary_10_1186_s13054_017_1935_3 crossref_primary_10_1038_s41598_021_94473_1 crossref_primary_10_3390_diagnostics11091559 crossref_primary_10_1016_j_mpaic_2019_03_007 crossref_primary_10_1016_j_chest_2024_03_006 crossref_primary_10_1001_jamanetworkopen_2025_12286 crossref_primary_10_3390_ijms20133260 crossref_primary_10_1016_j_annemergmed_2015_04_014 crossref_primary_10_1177_2377960819850972 crossref_primary_10_1097_pq9_0000000000000051 crossref_primary_10_1186_s13054_015_0794_z crossref_primary_10_1186_s13613_015_0084_6 crossref_primary_10_1016_j_medin_2016_06_006 crossref_primary_10_1186_s13054_016_1407_1 crossref_primary_10_1016_j_jcrc_2018_08_018 crossref_primary_10_1002_phar_2879 crossref_primary_10_1097_CCM_0000000000003658 crossref_primary_10_1016_j_ccc_2016_12_004 crossref_primary_10_1186_1471_2334_14_489 crossref_primary_10_1016_j_chest_2016_10_035 crossref_primary_10_1136_bmjopen_2015_009718 crossref_primary_10_1186_s40560_017_0239_7 crossref_primary_10_1097_CCM_0000000000002574 crossref_primary_10_3390_microorganisms9102016 crossref_primary_10_1097_ALN_0000000000000874 crossref_primary_10_5492_wjccm_v8_i4_36 crossref_primary_10_1177_08850666231180530 crossref_primary_10_1186_s40560_025_00776_0 crossref_primary_10_3390_ijms19020600 crossref_primary_10_1007_s10238_019_00584_5 crossref_primary_10_1136_bmjquality_u206760_w3983 crossref_primary_10_1016_j_annemergmed_2021_03_003 crossref_primary_10_1016_j_chest_2019_11_050 crossref_primary_10_1177_0885066619871247 crossref_primary_10_1097_CCM_0000000000001666 crossref_primary_10_1055_s_0041_1729742 crossref_primary_10_1097_PCC_0000000000001660 crossref_primary_10_12688_f1000research_6814_1 crossref_primary_10_1097_CCM_0000000000001427 crossref_primary_10_1007_s00134_018_5134_8 crossref_primary_10_1371_journal_pone_0154754 crossref_primary_10_1016_S1553_7250_16_42015_5 crossref_primary_10_1038_s41684_018_0217_2 crossref_primary_10_1177_175114371401500319 crossref_primary_10_1378_chest_13_2702 crossref_primary_10_1016_j_snb_2021_131120 crossref_primary_10_1097_TME_0000000000000188 crossref_primary_10_1002_ncp_10892 crossref_primary_10_1097_SHK_0000000000001128 crossref_primary_10_1097_SHK_0000000000002219 crossref_primary_10_1002_fsn3_1640 crossref_primary_10_1177_08850666231225173 crossref_primary_10_1111_nicc_12358 crossref_primary_10_1111_trf_12982 crossref_primary_10_1017_cem_2016_2 crossref_primary_10_1016_j_cvsm_2025_02_002 crossref_primary_10_1097_CCE_0000000000000019 crossref_primary_10_1186_s13017_016_0067_4 crossref_primary_10_1016_j_yasa_2021_07_005 crossref_primary_10_1002_jhm_2435 crossref_primary_10_1089_sur_2017_221 crossref_primary_10_1007_s00063_015_0005_3 crossref_primary_10_2217_cer_2022_0019 crossref_primary_10_5005_jp_journals_10071_24514 crossref_primary_10_1097_SHK_0000000000000260 crossref_primary_10_1097_TA_0000000000001135 crossref_primary_10_1097_CCM_0000000000002778 crossref_primary_10_1097_CCM_0000000000005804 crossref_primary_10_1186_s13054_017_1859_y crossref_primary_10_1016_j_medin_2022_03_001 crossref_primary_10_1371_journal_pone_0325679 crossref_primary_10_1007_s00134_014_3341_5 crossref_primary_10_1186_s13063_016_1515_x crossref_primary_10_1016_j_bjan_2017_03_008 crossref_primary_10_1097_CCM_0000000000002538 crossref_primary_10_1177_0194599817735500 crossref_primary_10_1080_15384101_2020_1826235 crossref_primary_10_1097_SHK_0000000000000268 crossref_primary_10_1001_jama_2023_7560 crossref_primary_10_1038_s41598_023_29926_w crossref_primary_10_1016_j_bpa_2014_09_004 crossref_primary_10_1164_rccm_201402_0289OC crossref_primary_10_1016_j_ccm_2016_01_004 crossref_primary_10_1038_s41569_020_00492_2 crossref_primary_10_1111_1742_6723_13154 crossref_primary_10_1177_0885066620982585 crossref_primary_10_1016_j_ajem_2016_03_037 crossref_primary_10_1016_j_annemergmed_2015_01_003 crossref_primary_10_1016_j_ccm_2016_01_002 crossref_primary_10_1378_chest_14_1256 crossref_primary_10_1016_j_bpa_2014_09_009 crossref_primary_10_1016_j_ccm_2016_01_007 crossref_primary_10_1016_j_ccm_2016_01_008 crossref_primary_10_1089_sur_2017_250 crossref_primary_10_1016_j_ccm_2016_01_006 crossref_primary_10_1016_j_jss_2019_01_035 crossref_primary_10_1016_j_bpa_2014_09_005 crossref_primary_10_1016_j_bpa_2014_09_006 crossref_primary_10_1089_sur_2017_255 crossref_primary_10_1007_s00134_014_3496_0 crossref_primary_10_1016_j_ccm_2016_01_009 crossref_primary_10_1007_s00063_014_0377_9 crossref_primary_10_1016_j_bpa_2014_09_008 crossref_primary_10_3389_fmed_2021_723837 crossref_primary_10_1186_cc14720 crossref_primary_10_1016_j_jen_2014_12_007 crossref_primary_10_1186_cc14725 crossref_primary_10_1111_joim_12326 crossref_primary_10_1186_cc14724 crossref_primary_10_1186_s12887_016_0634_6 crossref_primary_10_1186_s13054_016_1360_z crossref_primary_10_1186_s40560_016_0167_y crossref_primary_10_1016_j_jcrc_2021_07_003 crossref_primary_10_1186_cc14726 crossref_primary_10_1016_j_jcrc_2019_10_008 crossref_primary_10_1007_s00134_015_4133_2 crossref_primary_10_1097_CCM_0000000000000586 crossref_primary_10_4103_ijccm_IJCCM_367_18 crossref_primary_10_7554_eLife_21055 crossref_primary_10_1177_1060028019887160 crossref_primary_10_3389_fcvm_2021_684348 crossref_primary_10_3390_epidemiologia5030032 crossref_primary_10_1038_s41598_022_14764_z crossref_primary_10_1007_s00424_014_1643_7 crossref_primary_10_1016_j_jcrc_2019_10_005 crossref_primary_10_1016_j_ajem_2020_09_014 crossref_primary_10_1097_CCM_0000000000000591 crossref_primary_10_1007_s00101_016_0255_3 crossref_primary_10_1371_journal_pone_0213802 crossref_primary_10_1177_1751143718758975 crossref_primary_10_1016_j_ccm_2016_01_014 crossref_primary_10_1016_j_ccm_2016_01_015 crossref_primary_10_1186_s13054_015_0866_0 crossref_primary_10_1016_j_ccm_2016_01_012 crossref_primary_10_1186_cc14729 crossref_primary_10_7759_cureus_9257 crossref_primary_10_1016_j_ccm_2016_01_016 crossref_primary_10_1016_j_emc_2018_04_009 crossref_primary_10_1007_s00063_016_0172_x crossref_primary_10_1016_j_ccm_2016_01_017 crossref_primary_10_1016_j_ejim_2023_07_021 crossref_primary_10_1038_s41435_018_0030_3 crossref_primary_10_1016_j_jcrc_2014_10_015 crossref_primary_10_1093_ndt_gfad004 crossref_primary_10_1213_ANE_0000000000004343 crossref_primary_10_1055_s_0041_1740975 crossref_primary_10_1177_0885066616671710 crossref_primary_10_12677_ACREM_2017_54009 crossref_primary_10_7861_clinmedicine_18_3_225 crossref_primary_10_1186_s13613_017_0233_1 crossref_primary_10_1097_CCM_0000000000001868 crossref_primary_10_4103_ijccm_IJCCM_343_16 crossref_primary_10_3390_medicina59010047 crossref_primary_10_5492_wjccm_v5_i1_47 crossref_primary_10_1016_j_annemergmed_2021_02_006 crossref_primary_10_1097_CCM_0000000000000536 crossref_primary_10_1097_CCM_0000000000001867 crossref_primary_10_1111_joim_12331 crossref_primary_10_1310_hpj5101_19 crossref_primary_10_1007_s40265_017_0698_0 crossref_primary_10_1097_PCC_0000000000000375 crossref_primary_10_1177_08850666211023347 crossref_primary_10_1016_j_ijoa_2018_04_010 crossref_primary_10_1097_CCM_0000000000000541 crossref_primary_10_1038_s41598_018_28781_4 crossref_primary_10_1056_NEJMe1408976 crossref_primary_10_1016_j_annemergmed_2015_03_036 crossref_primary_10_1016_j_annemergmed_2017_06_006 crossref_primary_10_1177_0885066616671705 crossref_primary_10_1177_0885066617702591 crossref_primary_10_1136_bmjoq_2017_000080 crossref_primary_10_1177_2045894018769876 crossref_primary_10_1089_sur_2017_278 crossref_primary_10_17816_clinutr81626 crossref_primary_10_1097_CCM_0000000000001617 crossref_primary_10_1111_aas_12723 crossref_primary_10_4103_0972_5229_152759 crossref_primary_10_1016_j_jss_2015_12_048 crossref_primary_10_1097_MCC_0000000000000719 crossref_primary_10_1097_TA_0000000000003742 crossref_primary_10_1186_s13054_023_04507_5 crossref_primary_10_1136_postgradmedj_2016_134519 crossref_primary_10_1001_jamanetworkopen_2018_5845 crossref_primary_10_1016_j_ajem_2025_01_054 crossref_primary_10_1016_j_ajem_2025_01_055 crossref_primary_10_1038_s41598_020_77438_8 crossref_primary_10_1007_s00134_014_3598_8 crossref_primary_10_1007_s00134_016_4574_2 crossref_primary_10_5847_wjem_j_1920_8642_2017_01_004 crossref_primary_10_1007_s11908_016_0528_7 crossref_primary_10_1016_j_jcrc_2019_04_024 crossref_primary_10_1111_acem_12744 crossref_primary_10_1038_s41598_018_29427_1 crossref_primary_10_1055_s_0040_1713436 crossref_primary_10_1371_journal_pone_0181160 crossref_primary_10_1097_CCE_0000000000000056 crossref_primary_10_3389_fimmu_2025_1527142 crossref_primary_10_1186_s13054_020_2790_1 crossref_primary_10_1016_j_jcrc_2019_03_002 crossref_primary_10_1097_TME_0000000000000158 crossref_primary_10_1007_s00134_022_06798_8 crossref_primary_10_1007_s10049_018_0515_7 crossref_primary_10_1016_j_chest_2016_06_046 crossref_primary_10_1093_bjsopen_zrab106 crossref_primary_10_1164_rccm_201604_0723ED crossref_primary_10_1016_j_jemermed_2017_09_021 crossref_primary_10_1111_aas_13848 crossref_primary_10_1097_MAT_0000000000001642 crossref_primary_10_1136_bmjopen_2015_008244 crossref_primary_10_3390_jcm13226762 crossref_primary_10_4103_aca_ACA_56_17 crossref_primary_10_1186_s13613_020_00658_8 crossref_primary_10_1371_journal_pone_0129305 crossref_primary_10_1016_j_jemermed_2015_06_054 crossref_primary_10_1007_s00134_014_3332_6 crossref_primary_10_1016_j_bpa_2017_10_002 crossref_primary_10_1186_s12917_018_1427_y crossref_primary_10_3390_jcm14165774 crossref_primary_10_1016_j_jcrc_2015_05_017 crossref_primary_10_1002_ams2_659 crossref_primary_10_1016_j_ajem_2019_01_050 crossref_primary_10_1097_SHK_0000000000000697 crossref_primary_10_1016_j_jclinepi_2020_08_001 crossref_primary_10_1111_aas_12745 crossref_primary_10_1097_CCM_0000000000003817 crossref_primary_10_5847_wjem_j_1920_8642_2018_02_005 crossref_primary_10_1001_jama_2023_20134 crossref_primary_10_1007_s12098_015_1758_7 crossref_primary_10_3389_fped_2018_00308 crossref_primary_10_1080_0886022X_2022_2072338 crossref_primary_10_1038_s43856_024_00665_x crossref_primary_10_1002_lt_24030 crossref_primary_10_1016_j_ebiom_2016_06_014 crossref_primary_10_1097_CCM_0000000000004900 crossref_primary_10_1038_nrneph_2014_204 crossref_primary_10_1111_trf_16284 crossref_primary_10_3390_jpm13030486 crossref_primary_10_1080_10903127_2016_1274348 crossref_primary_10_1371_journal_pone_0192073 crossref_primary_10_1080_03007995_2016_1206872 crossref_primary_10_1097_CCM_0000000000000794 crossref_primary_10_1097_PCC_0000000000000385 crossref_primary_10_1016_j_chest_2024_01_028 crossref_primary_10_1136_thoraxjnl_2014_206744 crossref_primary_10_1164_rccm_201601_0090ED crossref_primary_10_1515_jbcpp_2015_0003 crossref_primary_10_1089_ther_2014_0019 crossref_primary_10_1177_0884533617695243 crossref_primary_10_1186_s13054_016_1414_2 crossref_primary_10_3389_fped_2018_00306 crossref_primary_10_1152_japplphysiol_00818_2019 crossref_primary_10_3390_jcm10153379 crossref_primary_10_1186_s40635_022_00473_4 crossref_primary_10_1515_cclm_2018_1178 crossref_primary_10_1097_CCM_0000000000001829 crossref_primary_10_1097_TA_0000000000004467 crossref_primary_10_1016_j_jemermed_2023_08_018 crossref_primary_10_1097_CCM_0000000000001824 crossref_primary_10_1007_s10049_017_0331_5 crossref_primary_10_1186_2197_425X_3_S1_A220 crossref_primary_10_1186_s13613_023_01101_4 crossref_primary_10_1016_j_clml_2019_10_001 crossref_primary_10_1155_2017_9616545 crossref_primary_10_1016_j_ajem_2018_01_004 crossref_primary_10_1186_s12944_015_0022_5 crossref_primary_10_1111_1742_6723_13893 crossref_primary_10_1136_bmjopen_2017_017581 crossref_primary_10_1186_s13054_018_2078_x crossref_primary_10_12688_f1000research_8991_1 crossref_primary_10_1186_s13613_016_0231_8 crossref_primary_10_1513_AnnalsATS_201407_342OC crossref_primary_10_1016_j_annemergmed_2014_05_008 crossref_primary_10_1016_j_cnc_2018_05_002 crossref_primary_10_1016_j_mayocp_2014_11_014 crossref_primary_10_1080_14787210_2020_1794813 crossref_primary_10_1097_JHQ_0000000000000066 crossref_primary_10_1007_s00134_016_4500_7 crossref_primary_10_1016_j_chest_2018_10_012 crossref_primary_10_2146_ajhp160144 crossref_primary_10_1097_CCM_0000000000000960 crossref_primary_10_1177_1062860617692034 crossref_primary_10_1186_s12871_015_0054_4 crossref_primary_10_1016_j_jmii_2024_04_009 crossref_primary_10_1016_j_cnc_2018_05_008 crossref_primary_10_1016_j_ajic_2018_07_003 crossref_primary_10_1080_10903127_2019_1704321 crossref_primary_10_1155_2022_1802707 crossref_primary_10_1186_s13054_022_04176_w crossref_primary_10_1001_jamanetworkopen_2022_12709 crossref_primary_10_1002_phar_2371 crossref_primary_10_1016_j_chest_2024_07_141 crossref_primary_10_1093_bja_aev349 crossref_primary_10_1097_MCC_0000000000000640 crossref_primary_10_1016_j_bja_2021_06_048 crossref_primary_10_1097_DCC_0000000000000449 crossref_primary_10_1007_s00134_016_4437_x crossref_primary_10_1007_s00063_015_0001_7 crossref_primary_10_1155_2020_9281623 crossref_primary_10_1097_01_NPR_0000552679_69145_80 crossref_primary_10_1080_1354750X_2017_1401664 crossref_primary_10_1186_s40560_021_00555_7 crossref_primary_10_1016_j_jcrc_2016_06_017 crossref_primary_10_1016_j_cnc_2016_08_001 crossref_primary_10_1016_S1473_3099_15_70148_9 crossref_primary_10_1186_s40560_018_0345_1 crossref_primary_10_4103_0366_6999_154333 crossref_primary_10_1016_S1441_2772_23_01532_6 crossref_primary_10_1097_MCC_0000000000000603 crossref_primary_10_1097_SHK_0000000000001199 crossref_primary_10_1016_j_hlpt_2018_01_010 crossref_primary_10_1097_CCM_0000000000001847 crossref_primary_10_1053_j_ackd_2016_03_005 crossref_primary_10_3390_jcm8111800 crossref_primary_10_1186_s13054_014_0467_3 crossref_primary_10_1016_j_jcrc_2014_11_004 crossref_primary_10_2478_jccm_2023_0022 crossref_primary_10_1007_s13341_014_0442_2 crossref_primary_10_1016_j_acci_2016_01_002 crossref_primary_10_1186_s12882_017_0667_6 crossref_primary_10_1186_s13089_022_00282_6 crossref_primary_10_1186_s40560_017_0264_6 crossref_primary_10_1016_j_aat_2015_12_003 crossref_primary_10_1016_j_jcrc_2016_06_009 crossref_primary_10_1213_ANE_0000000000001614 crossref_primary_10_1016_j_ajem_2017_07_010 crossref_primary_10_1186_s13613_018_0402_x crossref_primary_10_1002_14651858_CD003709_pub4 crossref_primary_10_1089_sur_2020_047 crossref_primary_10_1097_CNQ_0000000000000553 crossref_primary_10_3390_biomedicines10123150 crossref_primary_10_1164_rccm_202309_1617OC crossref_primary_10_1016_j_jcrc_2016_06_027 crossref_primary_10_1111_vec_13230 crossref_primary_10_1097_MEJ_0000000000000379 crossref_primary_10_1016_j_jemermed_2016_08_009 crossref_primary_10_1016_j_jemermed_2016_10_028 crossref_primary_10_1097_CCM_0000000000000742 crossref_primary_10_1016_j_chest_2018_10_034 crossref_primary_10_1097_PCC_0000000000000858 crossref_primary_10_1097_MD_0000000000027593 crossref_primary_10_1007_s00101_018_0474_x crossref_primary_10_1093_jamiaopen_ooy013 crossref_primary_10_1136_bmjopen_2022_066056 crossref_primary_10_4187_respcare_08950 crossref_primary_10_1007_s00134_015_3764_7 crossref_primary_10_1097_CCM_0000000000006057 crossref_primary_10_1038_s41598_019_42972_7 crossref_primary_10_1016_j_jtemb_2015_02_005 crossref_primary_10_1111_micc_12483 crossref_primary_10_1213_ANE_0000000000001865 crossref_primary_10_3390_jcm12103496 crossref_primary_10_1097_MD_0000000000037380 crossref_primary_10_1164_rccm_201406_1032ED crossref_primary_10_1016_j_hpb_2018_07_022 crossref_primary_10_1186_s13741_015_0012_1 crossref_primary_10_1016_j_jemermed_2016_10_012 crossref_primary_10_1371_journal_pone_0299876 crossref_primary_10_1016_j_jcrc_2018_09_009 crossref_primary_10_1371_journal_pone_0327914 crossref_primary_10_1016_S1441_2772_23_00940_7 crossref_primary_10_1097_MCC_0000000000000421 crossref_primary_10_1097_MCC_0000000000000422 crossref_primary_10_1016_j_jcrc_2016_06_031 crossref_primary_10_1016_j_jcrc_2016_06_030 crossref_primary_10_1097_01_JAA_0000604904_81228_18 crossref_primary_10_4274_tybd_galenos_2019_41275 crossref_primary_10_1007_s00101_021_00962_3 crossref_primary_10_1161_CIR_0000000000001163 crossref_primary_10_1016_j_annemergmed_2024_12_016 crossref_primary_10_1056_NEJMc1413936 crossref_primary_10_2215_CJN_14381121 crossref_primary_10_4037_ccn2016268 crossref_primary_10_1097_CCM_0000000000006001 crossref_primary_10_1007_s13312_018_1269_5 crossref_primary_10_1188_16_CJON_281_288 crossref_primary_10_1016_j_ijid_2017_03_005 crossref_primary_10_1097_MEJ_0000000000000551 crossref_primary_10_1016_j_chest_2017_01_010 crossref_primary_10_1093_ofid_ofw010 crossref_primary_10_1016_j_ccc_2021_11_013 crossref_primary_10_1097_CCM_0000000000000929 crossref_primary_10_1007_s00108_023_01585_z crossref_primary_10_1016_j_amjms_2024_05_021 crossref_primary_10_1016_j_bios_2022_114414 crossref_primary_10_1016_j_ajem_2015_04_024 crossref_primary_10_1016_j_jemermed_2016_10_008 crossref_primary_10_3390_jcm10163587 crossref_primary_10_1186_s12873_023_00812_y crossref_primary_10_1056_NEJMoa1500704 crossref_primary_10_1186_s13054_014_0652_4 crossref_primary_10_1136_bmjgh_2017_000650 crossref_primary_10_1186_s13054_014_0578_x crossref_primary_10_1002_alz_70017 crossref_primary_10_1002_ams2_468 crossref_primary_10_1007_s00134_016_4666_z crossref_primary_10_1016_j_accpm_2015_12_003 crossref_primary_10_1513_AnnalsATS_201411_504OC crossref_primary_10_1513_AnnalsATS_201812_847IP crossref_primary_10_1111_aas_12479 crossref_primary_10_36290_vnl_2019_032 crossref_primary_10_1038_nrdp_2016_45 crossref_primary_10_1097_MCC_0000000000000407 crossref_primary_10_1056_NEJMra1309483 crossref_primary_10_1007_s12630_017_1045_3 crossref_primary_10_1097_MCC_0000000000000642 crossref_primary_10_1371_journal_pone_0197226 crossref_primary_10_1056_NEJMc1708979 crossref_primary_10_1016_j_jcrc_2016_05_017 crossref_primary_10_1371_journal_pone_0183073 crossref_primary_10_1097_MD_0000000000040733 crossref_primary_10_1007_s00210_019_01713_3 crossref_primary_10_1016_j_jcrc_2018_09_033 crossref_primary_10_1378_chest_15_1703 crossref_primary_10_1001_jama_2018_9183 crossref_primary_10_1007_s00134_015_3720_6 crossref_primary_10_1016_S2213_2600_14_70298_X crossref_primary_10_1080_17474124_2024_2443813 crossref_primary_10_1016_j_jemermed_2014_06_016 crossref_primary_10_1136_emermed_2017_207383 crossref_primary_10_1186_s13054_015_1014_6 crossref_primary_10_1111_1742_6723_13223 crossref_primary_10_1002_emp2_12358 crossref_primary_10_1097_CCM_0000000000006493 crossref_primary_10_1136_bmjopen_2021_050464 crossref_primary_10_7759_cureus_14752 crossref_primary_10_1088_1361_6579_ad75e4 crossref_primary_10_1016_j_cej_2021_128888 crossref_primary_10_1097_PCC_0000000000002198 crossref_primary_10_1016_S1441_2772_23_00942_0 crossref_primary_10_3389_fcimb_2023_1192931 crossref_primary_10_1016_j_ajem_2018_04_050 crossref_primary_10_1177_2327857915041032 crossref_primary_10_1097_CCM_0000000000005357 crossref_primary_10_1164_rccm_201908_1595WS crossref_primary_10_1128_AAC_03923_14 crossref_primary_10_3389_fmed_2021_761656 crossref_primary_10_1016_j_medin_2017_03_008 crossref_primary_10_3389_fmed_2020_581082 crossref_primary_10_1097_SHK_0000000000000718 crossref_primary_10_1378_chest_15_1525 crossref_primary_10_1002_ncp_11188 crossref_primary_10_1007_s00063_013_0335_y crossref_primary_10_1016_j_ajogmf_2020_100149 crossref_primary_10_1177_0885066618823183 crossref_primary_10_1371_journal_pone_0188548 crossref_primary_10_1007_s00134_016_4237_3 crossref_primary_10_1186_s13613_017_0280_7 crossref_primary_10_1097_SHK_0000000000000954 crossref_primary_10_1007_s11739_015_1248_y crossref_primary_10_1016_j_eursup_2016_04_004 crossref_primary_10_1038_s41598_019_52819_w crossref_primary_10_1186_s13049_021_00833_1 crossref_primary_10_1097_SHK_0000000000000715 crossref_primary_10_1186_s13054_019_2684_2 crossref_primary_10_1111_jrh_12339 crossref_primary_10_1002_hast_403 crossref_primary_10_1016_j_critrevonc_2015_03_003 crossref_primary_10_1016_j_mayocp_2021_05_020 crossref_primary_10_1056_NEJMoa1404380 crossref_primary_10_1016_j_ccc_2020_06_004 crossref_primary_10_1056_NEJMe1402564 crossref_primary_10_1186_s13049_015_0193_0 crossref_primary_10_1186_s13613_018_0439_x crossref_primary_10_1186_s40001_025_02661_w crossref_primary_10_1097_MCC_0000000000000241 crossref_primary_10_1007_s10877_015_9683_x crossref_primary_10_1186_s13049_019_0609_3 crossref_primary_10_1016_j_resuscitation_2016_05_014 crossref_primary_10_1016_j_jemermed_2017_05_024 crossref_primary_10_1177_2053434517707971 crossref_primary_10_1186_s13741_021_00235_y crossref_primary_10_1164_rccm_201507_1489OC crossref_primary_10_1513_AnnalsATS_201504_187OC crossref_primary_10_1097_CNQ_0000000000000385 crossref_primary_10_1016_j_ajem_2019_10_023 crossref_primary_10_12968_jpar_2015_7_9_446 crossref_primary_10_1097_SHK_0000000000000701 crossref_primary_10_1007_s10620_019_05985_w crossref_primary_10_1097_SHK_0000000000000703 crossref_primary_10_3892_mmr_2016_5694 crossref_primary_10_1016_j_chest_2020_09_274 crossref_primary_10_1016_j_jcrc_2018_04_005 crossref_primary_10_1016_j_medin_2016_09_004 crossref_primary_10_1097_MCC_0000000000000203 crossref_primary_10_1136_bmjresp_2017_000234 crossref_primary_10_1007_s00134_020_06169_1 crossref_primary_10_1016_j_jcrc_2017_11_009 crossref_primary_10_1016_j_soin_2019_06_001 crossref_primary_10_1097_ACO_0000000000000273 crossref_primary_10_3389_fvets_2021_622127 crossref_primary_10_1177_08850666211053778 crossref_primary_10_1097_AOG_0000000000003241 crossref_primary_10_1097_CCM_0000000000006463 crossref_primary_10_1097_MCC_0000000000000211 crossref_primary_10_1016_j_mayocp_2015_03_028 crossref_primary_10_1007_s12028_017_0455_y crossref_primary_10_1097_CPM_0000000000000266 crossref_primary_10_1310_hpj5203_191 crossref_primary_10_1093_intqhc_mzy121 crossref_primary_10_3389_fimmu_2025_1546474 crossref_primary_10_1016_j_semnephrol_2019_10_004 crossref_primary_10_1136_bmjopen_2016_013502 crossref_primary_10_3390_microorganisms11092231 crossref_primary_10_1002_JLB_5MA0721_825R crossref_primary_10_1016_j_chest_2020_09_269 crossref_primary_10_1097_MCC_0000000000000212 crossref_primary_10_1097_MCC_0000000000001301 crossref_primary_10_3390_jcm9072052 crossref_primary_10_1097_MCC_0000000000000217 crossref_primary_10_1164_rccm_201505_0995OC crossref_primary_10_2460_ajvr_82_7_566 crossref_primary_10_1007_s00134_015_3733_1 crossref_primary_10_1186_s13054_017_1798_7 crossref_primary_10_1097_CCM_0000000000006694 crossref_primary_10_1186_s13012_022_01221_8 crossref_primary_10_1007_s40121_014_0037_7 crossref_primary_10_1016_j_mpaic_2018_09_003 crossref_primary_10_1007_s00063_025_01317_1 crossref_primary_10_1097_SHK_0000000000000929 crossref_primary_10_1371_journal_pone_0264517 crossref_primary_10_1007_s00134_016_4590_2 crossref_primary_10_1093_bja_aev163 crossref_primary_10_1186_s40560_017_0240_1 crossref_primary_10_1016_j_anclin_2014_11_003 crossref_primary_10_1038_s41598_019_45252_6 crossref_primary_10_1097_ACO_0000000000000446 crossref_primary_10_1016_j_jcrc_2017_10_019 crossref_primary_10_1186_s12887_018_1059_1 crossref_primary_10_1007_s00059_015_4336_x crossref_primary_10_1586_1744666X_2014_932250 crossref_primary_10_1007_s00398_017_0142_5 crossref_primary_10_1007_s10877_015_9672_0 crossref_primary_10_1016_j_ajem_2015_06_012 crossref_primary_10_1016_j_jcrc_2016_02_022 crossref_primary_10_1001_jamahealthforum_2022_1173 crossref_primary_10_1093_bja_aev137 crossref_primary_10_1186_s13054_015_0751_x crossref_primary_10_1007_s00134_015_3857_3 crossref_primary_10_1016_j_bjane_2014_11_006 crossref_primary_10_1007_s00292_017_0301_1 crossref_primary_10_1111_ecc_13018 crossref_primary_10_1186_s40560_015_0105_4 crossref_primary_10_1038_cr_2015_61 crossref_primary_10_1097_PTS_0000000000001289 crossref_primary_10_1002_aet2_10023 crossref_primary_10_1007_s00134_015_4193_3 crossref_primary_10_1164_rccm_201906_1214LE crossref_primary_10_1177_2050312120928732 crossref_primary_10_1016_j_chstcc_2025_100151 crossref_primary_10_1016_j_ajem_2015_08_039 crossref_primary_10_1371_journal_pone_0125827 crossref_primary_10_1186_s13054_018_2169_8 crossref_primary_10_3389_fphys_2019_01321 crossref_primary_10_1136_emermed_2020_210298 crossref_primary_10_5847_wjem_j_1920_8642_2022_101 crossref_primary_10_1136_archdischild_2015_310234 crossref_primary_10_1097_CCE_0000000000000610 crossref_primary_10_3389_fped_2018_00087 crossref_primary_10_1186_s13613_016_0226_5 crossref_primary_10_3390_life15010124 crossref_primary_10_1177_0885066617711882 crossref_primary_10_1186_s13054_019_2588_1 crossref_primary_10_1177_2053434517732507 crossref_primary_10_1007_s10049_015_0097_6 crossref_primary_10_1053_j_jvca_2014_10_029 crossref_primary_10_1371_journal_pntd_0005740 crossref_primary_10_3389_fmed_2022_794423 crossref_primary_10_1371_journal_pone_0167230 crossref_primary_10_2215_CJN_14191021 crossref_primary_10_3389_frai_2022_842306 crossref_primary_10_1053_j_ackd_2016_02_006 crossref_primary_10_1186_s13054_014_0619_5 crossref_primary_10_1053_j_jvca_2019_10_029 crossref_primary_10_1164_rccm_201712_2545OC crossref_primary_10_1164_rccm_201404_0632ED crossref_primary_10_1186_s13012_017_0706_5 crossref_primary_10_1097_MCC_0000000000000248 crossref_primary_10_1007_s00134_025_07910_4 crossref_primary_10_1097_CCM_0000000000005337 crossref_primary_10_1093_bja_aev118 crossref_primary_10_1097_CCM_0000000000004000 crossref_primary_10_1164_rccm_201609_1848OC crossref_primary_10_1007_s00101_017_0299_z crossref_primary_10_1007_s00134_014_3525_z crossref_primary_10_1016_j_anclin_2019_10_013 crossref_primary_10_1111_aas_14026 crossref_primary_10_1373_jalm_2018_026377 crossref_primary_10_1186_s12873_022_00650_4 crossref_primary_10_1016_j_ijregi_2025_100695 crossref_primary_10_1016_j_medin_2017_01_003 crossref_primary_10_1097_MD_0000000000008657 crossref_primary_10_1002_aet2_10045 crossref_primary_10_1097_JHQ_0000000000000440 crossref_primary_10_1007_s00011_016_0937_y crossref_primary_10_1007_s00134_017_4821_1 crossref_primary_10_1016_j_jinf_2024_106395 crossref_primary_10_1016_j_jcrc_2017_10_007 crossref_primary_10_1016_j_ogc_2016_07_010 crossref_primary_10_1016_S0140_6736_18_30696_2 crossref_primary_10_1016_S0140_6736_19_32563_2 crossref_primary_10_2147_JIR_S370788 crossref_primary_10_1097_ALN_0000000000004958 crossref_primary_10_1097_CCM_0000000000006652 crossref_primary_10_1097_TA_0000000000000938 crossref_primary_10_1016_j_jcrc_2017_11_036 crossref_primary_10_1186_s13054_018_2210_y crossref_primary_10_1007_s00134_015_3822_1 crossref_primary_10_1016_j_lfs_2020_118606 |
| Cites_doi | 10.1097/01.CCM.0000298158.12101.41 10.1056/NEJMoa010307 10.1378/chest.101.6.1644 10.1007/s00134-013-2933-9 10.1097/01.ccm.0000298122.49245.d7 10.1111/j.1553-2712.2007.tb02391.x 10.1056/NEJM199902113400601 10.1016/0021-9681(87)90171-8 10.1056/NEJMra1208623 10.1097/00003246-200107000-00002 10.1056/NEJM200005043421801 10.1001/jama.2010.158 10.1097/01.CCM.0000277043.85378.C1 10.1097/01.CCM.0000117317.18092.E4 10.1136/emj.2008.070912 10.1007/s00134-009-1650-x 10.1007/s00134-008-0999-6 |
| ContentType | Journal Article |
| Contributor | Miner, James R Filbin, Michael R Sinert, Richard Pike, Francis Gunn, Scott R Parmar, Siddharth Bajwa, Ednan K Kelly, Matthew Conrad, Steven A Ufberg, Jacob W Wang, Henry E Fine, Jonathan Phillips, Carolyn A McCurdy, Michael T Huang, David T Berry, Donald A Carlson, Richard Self, Wesley H Allen, Todd L Ellender, Timothy J Orban, David J Angus, Derek C Rittenberger, Jon S Gimbel, Elizabeth Swadron, Stuart Wilson, Jason W Pearl, Ronald G Weinert, Craig Edwards, Andrew R Wojnar, Margaret Bernard, Gordon R Wofford, Kourtney A Venkat, Arvind Stapleton, Diana K Terndrup, Thomas Keener, Christopher Yealy, Donald M Parekh, Sohan Kulstad, Erik Landis, Kyle Brock, Daniel W Kellum, John A LoVecchio, Frank Sama, Andrew E Harris, Estelle S Rubenfeld, Gordon D Limkakeng, Jr, Alexander T Hou, Peter C Wilber, Scott T Dubinski, Diane Cnaan, Avital Fost, Norman C Mainhart, Allison Delbridge, Theodore R Albertson, Timothy Watts, Hannah Nathens, Avery B Willochell, Michael Migues, Ronald M Grissom, Colin K Parry, Blair A Lewis, Roger J Nafeei, Soheil Weissfeld, Lisa A |
| Contributor_xml | – sequence: 1 givenname: Derek C surname: Angus fullname: Angus, Derek C – sequence: 2 givenname: Amber E surname: Barnato fullname: Barnato, Amber E – sequence: 3 givenname: Tammy L surname: Eaton fullname: Eaton, Tammy L – sequence: 4 givenname: Elizabeth surname: Gimbel fullname: Gimbel, Elizabeth – sequence: 5 givenname: David T surname: Huang fullname: Huang, David T – sequence: 6 givenname: Christopher surname: Keener fullname: Keener, Christopher – sequence: 7 givenname: John A surname: Kellum fullname: Kellum, John A – sequence: 8 givenname: Kyle surname: Landis fullname: Landis, Kyle – sequence: 9 givenname: Francis surname: Pike fullname: Pike, Francis – sequence: 10 givenname: Diana K surname: Stapleton fullname: Stapleton, Diana K – sequence: 11 givenname: Lisa A surname: Weissfeld fullname: Weissfeld, Lisa A – sequence: 12 givenname: Michael surname: Willochell fullname: Willochell, Michael – sequence: 13 givenname: Kourtney A surname: Wofford fullname: Wofford, Kourtney A – sequence: 14 givenname: Donald M surname: Yealy fullname: Yealy, Donald M – sequence: 15 givenname: Erik surname: Kulstad fullname: Kulstad, Erik – sequence: 16 givenname: Hannah surname: Watts fullname: Watts, Hannah – sequence: 17 givenname: Arvind surname: Venkat fullname: Venkat, Arvind – sequence: 18 givenname: Peter C surname: Hou fullname: Hou, Peter C – sequence: 19 givenname: Anthony surname: Massaro fullname: Massaro, Anthony – sequence: 20 givenname: Siddharth surname: Parmar fullname: Parmar, Siddharth – sequence: 21 givenname: Alexander T surname: Limkakeng, Jr fullname: Limkakeng, Jr, Alexander T – sequence: 22 givenname: Kori surname: Brewer fullname: Brewer, Kori – sequence: 23 givenname: Theodore R surname: Delbridge fullname: Delbridge, Theodore R – sequence: 24 givenname: Allison surname: Mainhart fullname: Mainhart, Allison – sequence: 25 givenname: Lakhmir S surname: Chawla fullname: Chawla, Lakhmir S – sequence: 26 givenname: James R surname: Miner fullname: Miner, James R – sequence: 27 givenname: Todd L surname: Allen fullname: Allen, Todd L – sequence: 28 givenname: Colin K surname: Grissom fullname: Grissom, Colin K – sequence: 29 givenname: Stuart surname: Swadron fullname: Swadron, Stuart – sequence: 30 givenname: Steven A surname: Conrad fullname: Conrad, Steven A – sequence: 31 givenname: Richard surname: Carlson fullname: Carlson, Richard – sequence: 32 givenname: Frank surname: LoVecchio fullname: LoVecchio, Frank – sequence: 33 givenname: Ednan K surname: Bajwa fullname: Bajwa, Ednan K – sequence: 34 givenname: Michael R surname: Filbin fullname: Filbin, Michael R – sequence: 35 givenname: Blair A surname: Parry fullname: Parry, Blair A – sequence: 36 givenname: Timothy J surname: Ellender fullname: Ellender, Timothy J – sequence: 37 givenname: Andrew E surname: Sama fullname: Sama, Andrew E – sequence: 38 givenname: Jonathan surname: Fine fullname: Fine, Jonathan – sequence: 39 givenname: Soheil surname: Nafeei fullname: Nafeei, Soheil – sequence: 40 givenname: Thomas surname: Terndrup fullname: Terndrup, Thomas – sequence: 41 givenname: Margaret surname: Wojnar fullname: Wojnar, Margaret – sequence: 42 givenname: Ronald G surname: Pearl fullname: Pearl, Ronald G – sequence: 43 givenname: Scott T surname: Wilber fullname: Wilber, Scott T – sequence: 44 givenname: Richard surname: Sinert fullname: Sinert, Richard – sequence: 45 givenname: David J surname: Orban fullname: Orban, David J – sequence: 46 givenname: Jason W surname: Wilson fullname: Wilson, Jason W – sequence: 47 givenname: Jacob W surname: Ufberg fullname: Ufberg, Jacob W – sequence: 48 givenname: Timothy surname: Albertson fullname: Albertson, Timothy – sequence: 49 givenname: Edward A surname: Panacek fullname: Panacek, Edward A – sequence: 50 givenname: Sohan surname: Parekh fullname: Parekh, Sohan – sequence: 51 givenname: Scott R surname: Gunn fullname: Gunn, Scott R – sequence: 52 givenname: Jon S surname: Rittenberger fullname: Rittenberger, Jon S – sequence: 53 givenname: Richard J surname: Wadas fullname: Wadas, Richard J – sequence: 54 givenname: Andrew R surname: Edwards fullname: Edwards, Andrew R – sequence: 55 givenname: Matthew surname: Kelly fullname: Kelly, Matthew – sequence: 56 givenname: Henry E surname: Wang fullname: Wang, Henry E – sequence: 57 givenname: Talmage M surname: Holmes fullname: Holmes, Talmage M – sequence: 58 givenname: Michael T surname: McCurdy fullname: McCurdy, Michael T – sequence: 59 givenname: Craig surname: Weinert fullname: Weinert, Craig – sequence: 60 givenname: Estelle S surname: Harris fullname: Harris, Estelle S – sequence: 61 givenname: Wesley H surname: Self fullname: Self, Wesley H – sequence: 62 givenname: Diane surname: Dubinski fullname: Dubinski, Diane – sequence: 63 givenname: Carolyn A surname: Phillips fullname: Phillips, Carolyn A – sequence: 64 givenname: Ronald M surname: Migues fullname: Migues, Ronald M – sequence: 65 givenname: Gordon R surname: Bernard fullname: Bernard, Gordon R – sequence: 66 givenname: Donald A surname: Berry fullname: Berry, Donald A – sequence: 67 givenname: Daniel W surname: Brock fullname: Brock, Daniel W – sequence: 68 givenname: Avital surname: Cnaan fullname: Cnaan, Avital – sequence: 69 givenname: Norman C surname: Fost fullname: Fost, Norman C – sequence: 70 givenname: Roger J surname: Lewis fullname: Lewis, Roger J – sequence: 71 givenname: Avery B surname: Nathens fullname: Nathens, Avery B – sequence: 72 givenname: Gordon D surname: Rubenfeld fullname: Rubenfeld, Gordon D |
| Copyright | Copyright © 2014 Massachusetts Medical Society. All rights reserved. 2015 INIST-CNRS Copyright © 2014 Massachusetts Medical Society. 2014 |
| Copyright_xml | – notice: Copyright © 2014 Massachusetts Medical Society. All rights reserved. – notice: 2015 INIST-CNRS – notice: Copyright © 2014 Massachusetts Medical Society. 2014 |
| CorporateAuthor | The ProCESS Investigators ProCESS Investigators |
| CorporateAuthor_xml | – name: The ProCESS Investigators – name: ProCESS Investigators |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7RV 7X7 7XB 8AO 8C1 8FE 8FH 8FI ABUWG AFKRA AN0 AZQEC BBNVY BEC BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH HCIFZ K0Y LK8 M0R M0T M1P M2M M2O M2P M7P MBDVC NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ Q9U 7X8 5PM |
| DOI | 10.1056/NEJMoa1401602 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Nursing & Allied Health Database Health & Medical Collection ProQuest Central (purchase pre-March 2016) ProQuest Pharma Collection Public Health Database ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Hospital Collection ProQuest Central (Alumni) ProQuest Central UK/Ireland British Nursing Database ProQuest Central Essentials - QC Biological Science Collection eLibrary ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library SciTech Premium Collection New England Journal of Medicine Biological Sciences Consumer Health Database Healthcare Administration Database PML(ProQuest Medical Library) Psychology Database Research Library Science Database Biological Science Database Research Library (Corporate) Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Psychology Research Library Prep ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials elibrary ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing New England Journal of Medicine ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Research Library ProQuest Central (New) ProQuest Public Health ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest Family Health ProQuest One Academic Eastern Edition British Nursing Index with Full Text ProQuest Health Management ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic ProQuest One Psychology MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7RV name: Nursing & Allied Health Database url: https://search.proquest.com/nahs sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1533-4406 |
| EndPage | 1693 |
| ExternalDocumentID | PMC4101700 3291723331 24635773 28361396 10_1056_NEJMoa1401602 NJ201405013701805 |
| Genre | Original Article Multicenter Study Randomized Controlled Trial Journal Article Research Support, N.I.H., Extramural |
| GeographicLocations | United States--US Pittsburgh Pennsylvania |
| GeographicLocations_xml | – name: United States--US – name: Pittsburgh Pennsylvania |
| GrantInformation_xml | – fundername: NCATS NIH HHS grantid: UL1 TR000005 – fundername: NIGMS NIH HHS grantid: P50 GM076659 |
| GroupedDBID | - 0R 0WA 123 186 1KJ 1VV 29N 2KS 2WC 34G 39C 3V. 4 4.4 53G 55 5D0 5RE 7FN 7RV 7X7 85S 8AO 8C1 8FE 8FH 8FI AACLI AAEJM AAIKC AAJWC AALRV AAPBV AAQQT AARDX AAWTL ABACO ABEHJ ABFLS ABIVO ABOCM ABPPZ ABPTK ABQIJ ABUWG ABWJO ACGFS ACGOD ACJLH ACNCT ACPRK ACRZS ADBBV ADBIT ADCBC ADRHT AENEX AETEA AFFNX AFHKK AFKRA AGFXO AGNAY AHMBA AJJEV AJVPN ALMA_UNASSIGNED_HOLDINGS AN0 AQUVI AZQEC BBAFP BBNVY BCU BENPR BES BHPHI BKEYQ BKNYI BLC BNQBC BPHCQ BVXVI C45 CJ0 CO CS3 DCD DU5 DWQXO DZ EBS EJD ET EX3 F20 F5P FD8 FM. FYUFA GJ GNUQQ GUQSH H13 HCIFZ HZ I4R IH2 K-O KM KOO L7B LK8 M0R M0T M1P M2M M2O M2P M7P MVM N9A NAPCQ NEJ O9- OK1 OMK OVD P-O P-S P2P PADUT PCD PEA PQEST PQQKQ PQUKI PRINS PROAC PSQYO QJJ RHI RWL RXW S10 S6N SJFOW SJN TAE TAF TEORI TN5 TUQ TWZ UCV UKR UMD UQL VQA W2G WH7 WOQ WOW X X7M XJT XYN XZL YCJ YNT YRY YZZ ZA5 ZHY ZKB --- -DZ -ET -~X .-4 .55 .CO .GJ 0R~ 1CY 36B 3O- 41~ 6TJ 8WZ 9M8 A6W AAMNW AAQOH AAUTI AAYXX ABBLC ABCQX ABDPE ABDQB ABEFU ABJNI ABUFD ACKOT ACPFK ACPVT ACTDY ADUKH ADXHL AERZD AFFDN AFFHD AGHSJ AJUXI BYPQX CCPQU CITATION D0S FA8 HF~ HMCUK HZ~ J5H LPU MQT N4W NHB OHT PHGZM PHGZT PJZUB PPXIY PQGLB PSYQQ QZG SKT UBX UKHRP WHG YFH YHZ YQI YQJ YR2 YR5 YYP YYQ ZCA ZGI ZR0 ZVN ZXP ~KM AAYOK AFOSN ALIPV IQODW UIG XOL CGR CUY CVF ECM EIF NPM 7XB BEC K0Y MBDVC PKEHL Q9U 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c541t-eb7ad46f6a4854232dc8a9c3e5f70bfc23b1008c7b897951f921a9f36b0052d03 |
| IEDL.DBID | M2P |
| ISICitedReferencesCount | 1380 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000335405200006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0028-4793 1533-4406 |
| IngestDate | Tue Nov 04 01:43:10 EST 2025 Thu Sep 04 16:33:26 EDT 2025 Tue Oct 07 05:33:05 EDT 2025 Thu Apr 03 07:00:35 EDT 2025 Wed Apr 02 07:26:05 EDT 2025 Sat Nov 29 03:54:39 EST 2025 Tue Nov 18 19:58:40 EST 2025 Tue Dec 21 14:38:56 EST 2021 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 18 |
| Keywords | Infection Medicine Septic shock |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c541t-eb7ad46f6a4854232dc8a9c3e5f70bfc23b1008c7b897951f921a9f36b0052d03 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-3 ObjectType-Evidence Based Healthcare-1 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 A complete list of investigators in the Protocolized Care for Early Septic Shock (ProCESS) study is provided in the Supplementary Appendix, available at NEJM.org |
| OpenAccessLink | https://www.nejm.org/doi/pdf/10.1056/NEJMoa1401602?articleTools=true |
| PMID | 24635773 |
| PQID | 1520423050 |
| PQPubID | 40644 |
| PageCount | 11 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4101700 proquest_miscellaneous_1521324475 proquest_journals_1520423050 pubmed_primary_24635773 pascalfrancis_primary_28361396 crossref_citationtrail_10_1056_NEJMoa1401602 crossref_primary_10_1056_NEJMoa1401602 mms_nejm_10_1056_NEJMoa1401602 |
| PublicationCentury | 2000 |
| PublicationDate | 2014-05-01 |
| PublicationDateYYYYMMDD | 2014-05-01 |
| PublicationDate_xml | – month: 05 year: 2014 text: 2014-05-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Waltham, MA |
| PublicationPlace_xml | – name: Waltham, MA – name: United States – name: Boston |
| PublicationTitle | The New England journal of medicine |
| PublicationTitleAlternate | N Engl J Med |
| PublicationYear | 2014 |
| Publisher | Massachusetts Medical Society |
| Publisher_xml | – name: Massachusetts Medical Society |
| References | Pike, F, Yealy, DM, Kellum, JA (r008) 2013; 15 Bone, RC, Balk, RA, Cerra, FB (r011) 1992; 101 Reade, MC, Huang, DT, Bell, D (r007) 2010; 27 Rivers, EP, Katranji, M, Jaehne, KA (r018) 2012; 78 Reade, MC, Delaney, A, Bailey, MJ (r020) 2010; 36 Hebert, PC, Wells, G, Blajchman, MA (r016) 1999; 340 Carlbom, DJ, Rubenfeld, GD (r005) 2007; 35 Jones, AE, Shapiro, NI, Roshon, M (r006) 2007; 14 Huang, DT, Angus, DC, Barnato, A (r019) 2013; 39 Dellinger, RP, Levy, MM, Carlet, JM (r010) 2008; 36 (r017) 2000; 342 Angus, DC, van der Poll, T (r002) 2013; 369 r013 Charlson, ME, Pompei, P, Ales, KL, MacKenzie, CR (r015) 1987; 40 Angus, DC, Linde-Zwirble, WT, Lidicker, J, Clermont, G, Carcillo, J, Pinsky, MR (r001) 2001; 29 Jones, AE, Shapiro, NI, Trzeciak, S, Arnold, RC, Claremont, HA, Kline, JA (r014) 2010; 303 Dellinger, RP, Carlet, JM, Masur, H (r009) 2004; 32 Minneci, PC, Eichacker, PQ, Danner, RL, Banks, SM, Natanson, C, Deans, KJ (r012) 2008; 34 Wang, HE, Shapiro, NI, Angus, DC, Yealy, DM (r003) 2007; 35 Rivers, E, Nguyen, B, Havstad, S (r004) 2001; 345 Pike F (r008) 2013; 15 r020 r010 r011 r001 r012 r006 r017 r007 r019 r009 r002 r003 r014 r004 r015 r005 r016 Rivers EP (r018) 2012; 78 24935515 - Ann Intern Med. 2014 Jun 17;160(12):JC9 20179283 - JAMA. 2010 Feb 24;303(8):739-46 23958738 - Intensive Care Med. 2013 Oct;39(10):1760-75 25054725 - N Engl J Med. 2014 Jul 24;371(4):384 25054727 - N Engl J Med. 2014 Jul 24;371(4):385 11794169 - N Engl J Med. 2001 Nov 8;345(19):1368-77 23984731 - N Engl J Med. 2013 Aug 29;369(9):840-51 1303622 - Chest. 1992 Jun;101(6):1644-55 25054728 - N Engl J Med. 2014 Jul 24;371(4):386 25271746 - Am J Respir Crit Care Med. 2014 Oct 1;190(7):827-8 9971864 - N Engl J Med. 1999 Feb 11;340(6):409-17 10793162 - N Engl J Med. 2000 May 4;342(18):1301-8 25054726 - N Engl J Med. 2014 Jul 24;371(4):384-5 19760395 - Intensive Care Med. 2010 Jan;36(1):11-21 25982917 - Intern Emerg Med. 2015 Sep;10(6):731-43 25054724 - N Engl J Med. 2014 Jul 24;371(4):386 18158437 - Crit Care Med. 2008 Jan;36(1):296-327 27030514 - Acta Anaesthesiol Scand. 2016 Aug;60(7):925-33 26037427 - Natl Med J India. 2014 Sep-Oct;27(5):267-8 24289512 - Crit Care Resusc. 2013 Dec;15(4):301-10 25166253 - Am J Nurs. 2014 Sep;114(9):69 15090974 - Crit Care Med. 2004 Mar;32(3):858-73 20156862 - Emerg Med J. 2010 Feb;27(2):110-5 11445675 - Crit Care Med. 2001 Jul;29(7):1303-10 3558716 - J Chronic Dis. 1987;40(5):373-83 18075366 - Crit Care Med. 2007 Nov;35(11):2525-32 24635774 - N Engl J Med. 2014 May 1;370(18):1750-1 24999776 - J R Coll Physicians Edinb. 2014;44(2):133 22447123 - Minerva Anestesiol. 2012 Jun;78(6):712-24 17630356 - Acad Emerg Med. 2007 Nov;14(11):1072-8 17581480 - Crit Care Med. 2007 Aug;35(8):1928-36 18214424 - Intensive Care Med. 2008 May;34(5):942-7 |
| References_xml | – volume: 35 start-page: 2525 year: 2007 end-page: 2532 ident: r005 article-title: Barriers to implementing protocol-based sepsis resuscitation in the emergency department -- results of a national survey. publication-title: Crit Care Med – volume: 40 start-page: 373 year: 1987 end-page: 383 ident: r015 article-title: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. publication-title: J Chronic Dis – volume: 101 start-page: 1644 year: 1992 end-page: 1655 ident: r011 article-title: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. publication-title: Chest – volume: 340 start-page: 409 year: 1999 end-page: 417 ident: r016 article-title: A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. publication-title: N Engl J Med ;[Erratum, N Engl J Med 1999;340:1056.] – volume: 39 start-page: 1760 year: 2013 end-page: 1775 ident: r019 article-title: Harmonizing international trials of early goal-directed resuscitation for severe sepsis and septic shock: methodology of ProCESS, ARISE, and ProMISe. publication-title: Intensive Care Med – volume: 78 start-page: 712 year: 2012 end-page: 724 ident: r018 article-title: Early interventions in severe sepsis and septic shock: a review of the evidence one decade later. publication-title: Minerva Anestesiol – volume: 35 start-page: 1928 year: 2007 end-page: 1936 ident: r003 article-title: National estimates of severe sepsis in United States emergency departments. publication-title: Crit Care Med – ident: r013 article-title: A handbook for clinical investigators conducting therapeutic clinical trials supported by CTEP, DCTD, NCI. Bethesda, MD: National Cancer Institute CTEP, 2013. – volume: 34 start-page: 942 year: 2008 end-page: 947 ident: r012 article-title: The importance of usual care control groups for safety monitoring and validity during critical care research. publication-title: Intensive Care Med – volume: 14 start-page: 1072 year: 2007 end-page: 1078 ident: r006 article-title: Implementing early goal-directed therapy in the emergency setting: the challenges and experiences of translating research innovations into clinical reality in academic and community settings. publication-title: Acad Emerg Med – volume: 29 start-page: 1303 year: 2001 end-page: 1310 ident: r001 article-title: Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. publication-title: Crit Care Med – volume: 303 start-page: 739 year: 2010 end-page: 746 ident: r014 article-title: Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. publication-title: JAMA – volume: 36 start-page: 11 year: 2010 end-page: 21 ident: r020 article-title: Prospective meta-analysis using individual patient data in intensive care medicine. publication-title: Intensive Care Med – volume: 369 start-page: 840 year: 2013 end-page: 851 ident: r002 article-title: Severe sepsis and septic shock. publication-title: N Engl J Med ;[Erratum, N Engl J Med 2013;369:2069.] – volume: 27 start-page: 110 year: 2010 end-page: 115 ident: r007 article-title: Variability in management of early severe sepsis. publication-title: Emerg Med J – volume: 15 start-page: 301 year: 2013 end-page: 310 ident: r008 article-title: Protocolized Care for Early Septic Shock (ProCESS) statistical analysis plan. publication-title: Crit Care Resusc – volume: 342 start-page: 1301 year: 2000 end-page: 1308 ident: r017 article-title: Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. publication-title: N Engl J Med ;The Acute Respiratory Distress Syndrome Network – volume: 345 start-page: 1368 year: 2001 end-page: 1377 ident: r004 article-title: Early goal-directed therapy in the treatment of severe sepsis and septic shock. publication-title: N Engl J Med – volume: 36 start-page: 296 year: 2008 end-page: 327 ident: r010 article-title: Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. publication-title: Crit Care Med ;[Erratum, Crit Care Med 2008;36:1394-6.] – volume: 32 start-page: 858 year: 2004 end-page: 873 ident: r009 article-title: Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. publication-title: Crit Care Med ;[Erratum, Crit Care Med 2004;32:1448, 2169-70.] – volume: 15 start-page: 301 year: 2013 ident: r008 publication-title: Crit Care Resusc – ident: r010 doi: 10.1097/01.CCM.0000298158.12101.41 – ident: r004 doi: 10.1056/NEJMoa010307 – ident: r011 doi: 10.1378/chest.101.6.1644 – ident: r019 doi: 10.1007/s00134-013-2933-9 – ident: r005 doi: 10.1097/01.ccm.0000298122.49245.d7 – ident: r006 doi: 10.1111/j.1553-2712.2007.tb02391.x – ident: r016 doi: 10.1056/NEJM199902113400601 – ident: r015 doi: 10.1016/0021-9681(87)90171-8 – ident: r002 doi: 10.1056/NEJMra1208623 – ident: r001 doi: 10.1097/00003246-200107000-00002 – volume: 78 start-page: 712 year: 2012 ident: r018 publication-title: Minerva Anestesiol – ident: r017 doi: 10.1056/NEJM200005043421801 – ident: r014 doi: 10.1001/jama.2010.158 – ident: r003 doi: 10.1097/01.CCM.0000277043.85378.C1 – ident: r009 doi: 10.1097/01.CCM.0000117317.18092.E4 – ident: r007 doi: 10.1136/emj.2008.070912 – ident: r020 doi: 10.1007/s00134-009-1650-x – ident: r012 doi: 10.1007/s00134-008-0999-6 – reference: 18214424 - Intensive Care Med. 2008 May;34(5):942-7 – reference: 25166253 - Am J Nurs. 2014 Sep;114(9):69 – reference: 25054726 - N Engl J Med. 2014 Jul 24;371(4):384-5 – reference: 24289512 - Crit Care Resusc. 2013 Dec;15(4):301-10 – reference: 11445675 - Crit Care Med. 2001 Jul;29(7):1303-10 – reference: 25982917 - Intern Emerg Med. 2015 Sep;10(6):731-43 – reference: 27030514 - Acta Anaesthesiol Scand. 2016 Aug;60(7):925-33 – reference: 1303622 - Chest. 1992 Jun;101(6):1644-55 – reference: 10793162 - N Engl J Med. 2000 May 4;342(18):1301-8 – reference: 11794169 - N Engl J Med. 2001 Nov 8;345(19):1368-77 – reference: 25054725 - N Engl J Med. 2014 Jul 24;371(4):384 – reference: 25054728 - N Engl J Med. 2014 Jul 24;371(4):386 – reference: 18075366 - Crit Care Med. 2007 Nov;35(11):2525-32 – reference: 25054724 - N Engl J Med. 2014 Jul 24;371(4):386 – reference: 9971864 - N Engl J Med. 1999 Feb 11;340(6):409-17 – reference: 24999776 - J R Coll Physicians Edinb. 2014;44(2):133 – reference: 24935515 - Ann Intern Med. 2014 Jun 17;160(12):JC9 – reference: 23958738 - Intensive Care Med. 2013 Oct;39(10):1760-75 – reference: 23984731 - N Engl J Med. 2013 Aug 29;369(9):840-51 – reference: 24635774 - N Engl J Med. 2014 May 1;370(18):1750-1 – reference: 19760395 - Intensive Care Med. 2010 Jan;36(1):11-21 – reference: 15090974 - Crit Care Med. 2004 Mar;32(3):858-73 – reference: 20179283 - JAMA. 2010 Feb 24;303(8):739-46 – reference: 22447123 - Minerva Anestesiol. 2012 Jun;78(6):712-24 – reference: 17630356 - Acad Emerg Med. 2007 Nov;14(11):1072-8 – reference: 25054727 - N Engl J Med. 2014 Jul 24;371(4):385 – reference: 20156862 - Emerg Med J. 2010 Feb;27(2):110-5 – reference: 17581480 - Crit Care Med. 2007 Aug;35(8):1928-36 – reference: 26037427 - Natl Med J India. 2014 Sep-Oct;27(5):267-8 – reference: 18158437 - Crit Care Med. 2008 Jan;36(1):296-327 – reference: 25271746 - Am J Respir Crit Care Med. 2014 Oct 1;190(7):827-8 – reference: 3558716 - J Chronic Dis. 1987;40(5):373-83 |
| SSID | ssj0000149 |
| Score | 2.6593788 |
| Snippet | In septic shock, the first few hours of care are critical for survival. In this study, two protocols for the care of patients with septic shock were compared... In a single-center study published more than a decade ago involving patients presenting to the emergency department with severe sepsis and septic shock,... BackgroundIn a single-center study published more than a decade ago involving patients presenting to the emergency department with severe sepsis and septic... |
| SourceID | pubmedcentral proquest pubmed pascalfrancis crossref mms |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1683 |
| SubjectTerms | Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anti-Bacterial Agents - therapeutic use Biological and medical sciences Blood Transfusion Cardiotonic Agents - therapeutic use Clinical Protocols Clinical trials Combined Modality Therapy Emergency and intensive care: infection, septic shock Emergency Service, Hospital Evidence-based medicine Female Fluid Therapy General aspects Hospital Mortality Humans Intensive care medicine Intravenous administration Male Medical sciences Medical treatment Middle Aged Mortality Outcome Assessment (Health Care) Protocol Resuscitation - standards Sepsis Septic shock Shock, Septic - diagnosis Shock, Septic - mortality Shock, Septic - therapy Vasoconstrictor Agents - therapeutic use |
| SummonAdditionalLinks | – databaseName: New England Journal of Medicine Current dbid: DCD link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3fT9swED4BQ4gXGNuADIaMhHha1DRx4vptQIf2sCEEBfUt8o9YLaIJagsP_PXcJWkhAzTtORdLPt_Z3_nO3wEcSKPjdhRrXxphfe6S2CeWKd9qmRhpeMjLaovr3-LsrNPvy_MFaM3ewuTZzahM4JNH0w30rDt8i3rDF4rigYTIIz-QrZEZd0-6L_iiarxbXxnVpJqvfm8cQouj0YRKItUEteKqdhZv4c2_yyZfnEOn6_89g4-wVkNOdlTZyAYsZPknWPlTJ9U_w48jdqFyW4yGj5llPbJIVjh2Pi6mBZqJf4wHnWX0UIkhwmUlJTK7pGoYwy4HuJ9-gavTn72TX37dWME3MW9P_UwLZXniEsU7MWVqrekoaaIsdiLQzoSRJs4fI3RHCoRgToZtJV2UlLfINog2YSkv8mwbmBXaoZQLEQdhpC2lCSKpOTehUBgaCg--zzSdmpp1nJpf3KZl9jtO0oZWPDici99VdBvvCe7hsqWk7HcFGis6Hw7xFEIYmXiwO1vitPbbSYpohgqFgjjwYH_-GT2O0igqz4r7UgZDeCJK9GCrsojnwTnx-4nIA9GwlbkAsXk3v-TDQcnqzWlzDIKv_5rYDqwiaONV0eUuLE3H99k3WDYP0-FkvFf6wxMd5QJF priority: 102 providerName: Massachusetts Medical Society |
| Title | A Randomized Trial of Protocol-Based Care for Early Septic Shock |
| URI | https://nejm.org/doi/full/10.1056/NEJMoa1401602 https://www.ncbi.nlm.nih.gov/pubmed/24635773 https://www.proquest.com/docview/1520423050 https://www.proquest.com/docview/1521324475 https://pubmed.ncbi.nlm.nih.gov/PMC4101700 |
| Volume | 370 |
| WOSCitedRecordID | wos000335405200006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVBGY databaseName: New England Journal of Medicine Current customDbUrl: eissn: 1533-4406 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: DCD dateStart: 19900101 isFulltext: true titleUrlDefault: https://www.nejm.org/medical-index providerName: Massachusetts Medical Society – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1533-4406 dateEnd: 20250909 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: M7P dateStart: 19800103 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Consumer Health Database customDbUrl: eissn: 1533-4406 dateEnd: 20250909 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: M0R dateStart: 19800103 isFulltext: true titleUrlDefault: https://search.proquest.com/familyhealth providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1533-4406 dateEnd: 20250909 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: 7X7 dateStart: 19800103 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Healthcare Administration Database customDbUrl: eissn: 1533-4406 dateEnd: 20250909 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: M0T dateStart: 19800103 isFulltext: true titleUrlDefault: https://search.proquest.com/healthmanagement providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1533-4406 dateEnd: 20250909 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: 7RV dateStart: 19800103 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest - Psychology Database customDbUrl: eissn: 1533-4406 dateEnd: 20250909 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: M2M dateStart: 19800103 isFulltext: true titleUrlDefault: https://www.proquest.com/psychology providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1533-4406 dateEnd: 20250909 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: BENPR dateStart: 19800103 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database (ProQuest) customDbUrl: eissn: 1533-4406 dateEnd: 20250909 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: 8C1 dateStart: 19800103 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Research Library customDbUrl: eissn: 1533-4406 dateEnd: 20250909 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: M2O dateStart: 19800103 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest – providerCode: PRVPQU databaseName: Science Journals (ProQuest Database) customDbUrl: eissn: 1533-4406 dateEnd: 20250909 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: M2P dateStart: 19800103 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9NAEB6RFiEuvAuGEi0S4oRVP9Ze7wnatBUHEqw0VLlZ9q5XDSJ2SVIO_Hpm1pu0QZQLl5EsjyzbM975dmb8DcBbqaokjJPKl0pon5s08YllyteVTJVUPOK22-L8sxiNsulU5i7htnRtles10S7UulWUIz_AOEMtHEESfLj84dPUKKquuhEaPdhFZBNSS9cwym_QRzn46zJIjmMTY_4BTZpvS9pdpC6jso5Jvfl8SR2S5RJfkummW_wNfv7ZRXkjLJ0-_N8HegQPHCBlh50HPYY7dfME7g1dyf0pfDxk47LR7Xz2q9ZsQv7KWsPyRbtq0Yn8IwyDmtFvTAzxL7OEyeyMemUUO7vA1fYZfD09mQw--W7sgq8SHq78uhKl5qlJS54lVMfVKiuliuvEiKAyKoorYgRSosqkQIBmZBSW0sSpzTHrIN6DnaZt6hfAtKgMapkIURLuw6VUQSwrzlUkStw4Cg_er198oRwnOY3G-F7Y2niSFlt28uDdRv2yI-O4TbGPViya-tv8VoUtA28uh2gLAY5MPdhfW61wX_WyuDaZB282p_F7pCJL2dTtldXBDT7RKHrwvHOQ64tzYv8TsQdiy3U2CsT1vX2mmV1Yzm9OS2cQvPz3bb2C-wjoeNeQuQ87q8VV_Rruqp-r2XLRh54Yn5OcCiszlNkg7MPu0ckoH-PR8eAY5TAYWzkhGQ2t_GJlTlLkvwEepx2O |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3LbtQwFL1qC6Ld8KYNlGIkYEXUTOLE4wWC8qhadToa0QF1Fxw_1EFMUiZTqvJRfCP35jHtIMquC9a5sqz42PfYPj4X4JnUWdyJ4syXWhifuyT2yWXKN5lMtNQ85JXa4nNP9Pvdw0M5WIBf7VsYklW2a2K1UJtC0xn5JuYZknAEcfD6-LtPVaPodrUtoVHDYs-eneKWrXy1-x7H93kYbn8Yvtvxm6oCvo55Z-rbTCjDE5co3o3pmtLorpI6srETQeZ0GGVkeKNF1pUC-YeTYUdJFyXVEaoJImx3Ea5xchYjqWA4uGBX1dDt5sSq8fREjrFJle0LRbuZpDnBaXPg4nhckiJTlTgorq6m8Te6-6dq80Ia3L71v_3A23CzIdxsq54hd2DB5nfhxn4jKbgHb7bYR5WbYjz6aQ0b0nxkhWODSTEtcJL4bzHNG0bPtBjye1YZQrMD0gJpdnCE2eQ-fLqS_j-ApbzI7RowIzKHUS5EFsgT5No6iGTGuQ6Fwo2x8OBlO9CpbjzXqfTHt7S6-4-TdA4XHryYhR_XZiOXBW4gatLcfh1fGjAHqFlzyCaRwMnEg_UWJWmzapXpOUQ8eDr7jOsNXSKp3BYnVUwHSTgXsQerNSDPG-fkbigiD8QcVGcB5GU-_yUfHVWe5pxSQxA8_He3nsDyznC_l_Z2-3uPYAXJK6_Fp-uwNJ2c2MdwXf-YjsrJRjUxGXy5aiD_Bv_abrQ |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Nb9QwEB21BVVc-P4IlGIk4ES02cSO14cK-sGKqu1q1Zaqt5DYsbqITcpmCyo_jV_HTOJsu4hy64FzRpYVP3ue7ec3AK-UzkQ3EpmvtDQ-t7HwyWXKN5mKtdI85LXa4mhXDga942M1XIBf7VsYklW2a2K9UJtS0xl5B_MMSTgCEXSsk0UMt_rvTr_5VEGKblrbchoNRHby8x-4favWtrdwrF-HYf_D4eZH31UY8LXg3amfZzI1PLZxynuCriyN7qVKR7mwMsisDqOMzG-0zHpKIhexKuymykZxfZxqggjbXYQbkouQfPv3gv1L1lWOervTK-fviXyjQ1Xuy5R2NrE7zWnz4eJ4XJE6M61wgGxTWeNv1PdPBeellNi_8z__zLtw2xFxtt7MnHuwkBf3YXnPSQ0ewPt1tp8WphyPfuaGHdI8ZaVlw0k5LXHy-BuY_g2j51sMeT-rjaLZAWmENDs4wSzzED5dS_8fwVJRFvkTYEZmFqNsiOyQx8jBdRCpjHMdyhQ3zNKDt-2gJ9p5sVNJkK9JrQkQcTKHEQ_ezMJPGxOSqwJXEUFJkX8ZXxkwB65Zc8gykdip2IOVFjGJW82q5AIuHrycfcZ1iC6X0iIvz-qYLpJzLoUHjxtwXjTOyfVQRh7IOdjOAsjjfP5LMTqpvc45pYwgePrvbr2AZcRvsrs92HkGt5DT8kaTugJL08lZ_hxu6u_TUTVZrecog8_XjePfdVN3dw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+Randomized+Trial+of+Protocol-Based+Care+for+Early+Septic+Shock&rft.jtitle=The+New+England+journal+of+medicine&rft.au=The+ProCESS+Investigators&rft.date=2014-05-01&rft.pub=Massachusetts+Medical+Society&rft.issn=0028-4793&rft.eissn=1533-4406&rft.volume=370&rft.issue=18&rft.spage=1683&rft.epage=1693&rft_id=info:doi/10.1056%2FNEJMoa1401602&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=3291723331 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-4793&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-4793&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-4793&client=summon |