Altered static and dynamic functional network connectivity in primary angle-closure glaucoma patients

To explore altered patterns of static and dynamic functional brain network connectivity (sFNC and dFNC) in Primary angle-closure glaucoma (PACG) patients. Clinically confirmed 34 PACG patients and 33 age- and gender-matched healthy controls (HCs) underwent evaluation using T1 anatomical and function...

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Vydáno v:Scientific reports Ročník 14; číslo 1; s. 11682 - 11
Hlavní autoři: Wang, Yuanyuan, Shu, Yongqiang, Cai, Guoqian, Guo, Yu, Gao, Junwei, Chen, Ye, Lv, Lianjiang, Zeng, Xianjun
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 22.05.2024
Nature Publishing Group
Nature Portfolio
Témata:
692/308
692/308/53
Aged
Brain - diagnostic imaging
Brain - pathology
Brain - physiopathology
Brain functional network
Case-Control Studies
Dynamic functional network connectivity
Female
Functional magnetic resonance imaging
Glaucoma
Glaucoma, Angle-Closure - diagnostic imaging
Glaucoma, Angle-Closure - physiopathology
Humanities and Social Sciences
Humans
Magnetic Resonance Imaging
Male
Middle Aged
multidisciplinary
Nerve Net - diagnostic imaging
Nerve Net - physiopathology
Neural networks
Optic nerve
Primary angle-closure glaucoma
Science
Science (multidisciplinary)
Static functional network connectivity
Magnetic resonance imaging
Static functional network connectivity
Dynamic functional network connectivity
Brain functional network
Primary angle-closure glaucoma
ISSN:2045-2322, 2045-2322
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Popis
Shrnutí:To explore altered patterns of static and dynamic functional brain network connectivity (sFNC and dFNC) in Primary angle-closure glaucoma (PACG) patients. Clinically confirmed 34 PACG patients and 33 age- and gender-matched healthy controls (HCs) underwent evaluation using T1 anatomical and functional MRI on a 3 T scanner. Independent component analysis, sliding window, and the K-means clustering method were employed to investigate the functional network connectivity (FNC) and temporal metrics based on eight resting-state networks. Differences in FNC and temporal metrics were identified and subsequently correlated with clinical variables. For sFNC, compared with HCs, PACG patients showed three decreased interactions, including SMN-AN, SMN-VN and VN-AN pairs. For dFNC, we derived four highly structured states of FC that occurred repeatedly between individual scans and subjects, and the results are highly congruent with sFNC. In addition, PACG patients had a decreased fraction of time in state 3 and negatively correlated with IOP (p < 0.05). PACG patients exhibit abnormalities in both sFNC and dFNC. The high degree of overlap between static and dynamic results suggests the stability of functional connectivity networks in PACG patients, which provide a new perspective to understand the neuropathological mechanisms of optic nerve damage in PACG patients.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-62635-6