FGL2 promotes tumour growth and attenuates infiltration of activated immune cells in melanoma and ovarian cancer models

The tumour microenvironment is infiltrated by immunosuppressive cells, such as regulatory T cells (Tregs), which contribute to tumour escape and impede immunotherapy outcomes. Soluble fibrinogen-like protein 2 (sFGL2), a Treg effector protein, inhibits immune cell populations, via receptors FcγRIIB...

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Bibliographic Details
Published in:	Scientific reports Vol. 14; no. 1; pp. 787 - 15
Main Authors:	Galpin, Kristianne J. C., Rodriguez, Galaxia M., Maranda, Vincent, Cook, David P., Macdonald, Elizabeth, Murshed, Humaira, Zhao, Shan, McCloskey, Curtis W., Chruscinski, Andrzej, Levy, Gary A., Ardolino, Michele, Vanderhyden, Barbara C.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 08.01.2024 Nature Publishing Group Nature Portfolio
Subjects:	631/67/1059/2325 631/67/580 Animal models Animals Antigen-Presenting Cells BRCA2 protein Breast cancer Carcinoma, Ovarian Epithelial CD226 antigen CD25 antigen CD40 antigen CD86 antigen Cell activation Dendritic cells Down-regulation Female Fgl2 protein Fibrinogen Glioblastoma Humanities and Social Sciences Humans Immunoregulation Immunotherapy Liver cancer Lymphocytes Lymphocytes T Macrophages Male Melanoma Metastases Mice Monocytes multidisciplinary Natural killer cells Oncolysis Ovarian cancer Ovarian Neoplasms - therapy Prostate cancer Prostatic Neoplasms Science Science (multidisciplinary) Tumor Microenvironment Tumors
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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