SARS-CoV-2 infection establishes a stable and age-independent CD8+ T cell response against a dominant nucleocapsid epitope using restricted T cell receptors

The resolution of SARS-CoV-2 replication hinges on cell-mediated immunity, wherein CD8 + T cells play a vital role. Nonetheless, the characterization of the specificity and TCR composition of CD8 + T cells targeting non-spike protein of SARS-CoV-2 before and after infection remains incomplete. Here,...

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Bibliographic Details
Published in:	Nature communications Vol. 14; no. 1; pp. 6725 - 19
Main Authors:	Choy, Cecily, Chen, Joseph, Li, Jiangyuan, Gallagher, D. Travis, Lu, Jian, Wu, Daichao, Zou, Ainslee, Hemani, Humza, Baptiste, Beverly A., Wichmann, Emily, Yang, Qian, Ciffelo, Jeffrey, Yin, Rui, McKelvy, Julia, Melvin, Denise, Wallace, Tonya, Dunn, Christopher, Nguyen, Cuong, Chia, Chee W., Fan, Jinshui, Ruffolo, Jeannie, Zukley, Linda, Shi, Guixin, Amano, Tomokazu, An, Yang, Meirelles, Osorio, Wu, Wells W., Chou, Chao-Kai, Shen, Rong-Fong, Willis, Richard A., Ko, Minoru S. H., Liu, Yu-Tsueng, De, Supriyo, Pierce, Brian G., Ferrucci, Luigi, Egan, Josephine, Mariuzza, Roy, Weng, Nan-Ping
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 23.10.2023 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/106 13/31 38/39 38/91 631/250/2152/1566 631/326/596/4130 CD8 antigen CD8-Positive T-Lymphocytes Cell activation Cell proliferation Cell-mediated immunity Chromatin COVID-19 Epitopes Epitopes, T-Lymphocyte Expanders Humanities and Social Sciences Humans Infections Lymphocytes Lymphocytes T multidisciplinary Nucleocapsid - metabolism Nucleocapsids Proteins Receptors Receptors, Antigen, T-Cell - metabolism SARS-CoV-2 - metabolism Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus Spike protein Stimulation Structural analysis T cell receptors Transcriptomes
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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