Bmi1 loss produces an increase in astroglial cells and a decrease in neural stem cell population and proliferation

The polycomb transcriptional repressor Bmi1 promotes cell cycle progression, controls cell senescence, and is implicated in brain development. Loss of Bmi1 leads to a decreased brain size and causes progressive ataxia and epilepsy. Recently, Bmi1 was shown to control neural stem cell (NSC) renewal....

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Veröffentlicht in:	The Journal of neuroscience Jg. 25; H. 24; S. 5774
Hauptverfasser:	Zencak, Dusan, Lingbeek, Merel, Kostic, Corinne, Tekaya, Meriem, Tanger, Ellen, Hornfeld, Dana, Jaquet, Muriel, Munier, Francis L, Schorderet, Daniel F, van Lohuizen, Maarten, Arsenijevic, Yvan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.06.2005
Schlagworte:	Animals Animals, Newborn Astrocytes - cytology Base Sequence Caudate Nucleus - physiology Cell Differentiation Cell Division Cerebral Cortex - physiology DNA Primers Gene Expression Regulation, Developmental Genetic Carrier Screening Gliosis - genetics In Situ Nick-End Labeling Mice Mice, Knockout Neurons - cytology Neurons - physiology Nuclear Proteins - deficiency Nuclear Proteins - genetics Polycomb Repressive Complex 1 Proto-Oncogene Proteins - deficiency Proto-Oncogene Proteins - genetics Putamen Repressor Proteins - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Stem Cells - cytology
ISSN:	1529-2401, 1529-2401
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