The role of vitamin D in cardiovascular disease and COVID-19

Patients with pre-existing cardiovascular disease (CVD) are at high risk for adverse outcomes with coronavirus disease 2019 (COVID-19). Further, COVID-19 infection is associated with numerous cardiovascular (CV) complications including arrhythmia, myocardial injury, cardiomyopathy, and thrombotic ev...

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Vydané v:Reviews in endocrine & metabolic disorders Ročník 23; číslo 2; s. 293 - 297
Hlavní autori: Driggin, Elissa, Madhavan, Mahesh V., Gupta, Aakriti
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: New York Springer US 01.04.2022
Springer
Springer Nature B.V
Predmet:
Alfacalcidol
Arrhythmia
Calcifediol
Cardiomyopathy
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - etiology
Cardiovascular Diseases - prevention & control
Clopidogrel
Complications and side effects
Contractility
Coronaviruses
COVID-19
COVID-19 - complications
COVID-19 - drug therapy
Diabetes
Dietary supplements
Diseases
Endocrinology
Humans
Immune response
Inflammation
Internal Medicine
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Risk factors
Virus diseases
Vitamin D
Vitamin D - physiology
Vitamin D - therapeutic use
Vitamin D Deficiency - complications
Vitamin D Deficiency - drug therapy
Vitamins - therapeutic use
COVID-19
Coronavirus
Vitamin D
Coagulopathy
ISSN:1389-9155, 1573-2606, 1573-2606
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Popis
Shrnutí:Patients with pre-existing cardiovascular disease (CVD) are at high risk for adverse outcomes with coronavirus disease 2019 (COVID-19). Further, COVID-19 infection is associated with numerous cardiovascular (CV) complications including arrhythmia, myocardial injury, cardiomyopathy, and thrombotic events. Increased susceptibility to COVID-19 and CV complications related to COVID-19 may be in part related to immune dysregulation and inflammation associated with CV disease which is exacerbated with viral infection. Vitamin D plays a major role in immune function and exerts anti-inflammatory effects, which may prove important in the context of CVD and COVID-19. To date, studies have shown minimal benefit for vitamin D supplementation in patients with COVID-19, though there are no studies specific to patients with CVD and related complications. Further, given that vitamin D has important protective effects on the CV system, including augmentation of myocardial contractility and anti-thrombotic effects, it is unknown if supplementation with vitamin D can mitigate CVD complications associated with COVID-19.
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ObjectType-Feature-2
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ISSN:1389-9155
1573-2606
1573-2606
DOI:10.1007/s11154-021-09674-w