Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies

Myeloid derived suppressor cells (MDSCs) are key regulators of immune responses and correlate with poor outcomes in hematologic malignancies. Here, we identify that MDSC mitochondrial fitness controls the efficacy of doxorubicin chemotherapy in a preclinical lymphoma model. Mechanistically, we show...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 2803 - 19
Main Authors:	Daneshmandi, Saeed, Choi, Jee Eun, Yan, Qi, MacDonald, Cameron R., Pandey, Manu, Goruganthu, Mounika, Roberts, Nathan, Singh, Prashant K., Higashi, Richard M., Lane, Andrew N., Fan, Teresa W-M., Wang, Jianmin, McCarthy, Philip L., Repasky, Elizabeth A., Mohammadpour, Hemn
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 30.03.2024 Nature Publishing Group Nature Portfolio
Subjects:	13/2 13/31 13/95 631/250/1932 631/45/320 631/67/2327 Adrenergic receptors Blood cancer Chemotherapy Disruption Down-regulation Doxorubicin Effectiveness Electron transport Electron transport chain Energy metabolism Fitness Glutamine Humanities and Social Sciences Immune response Lymphoma Malignancy Metabolism Mitochondria multidisciplinary Oxidative stress Reactive oxygen species Receptor mechanisms Receptors (physiology) Science Science (multidisciplinary) Stat3 protein Suppressor cells Tricarboxylic acid cycle Tumorigenesis
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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