Plasma proteomics identify biomarkers predicting Parkinson’s disease up to 7 years before symptom onset

Parkinson’s disease is increasingly prevalent. It progresses from the pre-motor stage (characterised by non-motor symptoms like REM sleep behaviour disorder), to the disabling motor stage. We need objective biomarkers for early/pre-motor disease stages to be able to intervene and slow the underlying...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 4759 - 18
Main Authors:	Hällqvist, Jenny, Bartl, Michael, Dakna, Mohammed, Schade, Sebastian, Garagnani, Paolo, Bacalini, Maria-Giulia, Pirazzini, Chiara, Bhatia, Kailash, Schreglmann, Sebastian, Xylaki, Mary, Weber, Sandrina, Ernst, Marielle, Muntean, Maria-Lucia, Sixel-Döring, Friederike, Franceschi, Claudio, Doykov, Ivan, Śpiewak, Justyna, Vinette, Héloїse, Trenkwalder, Claudia, Heywood, Wendy E., Mills, Kevin, Mollenhauer, Brit
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 18.06.2024 Nature Publishing Group Nature Portfolio
Subjects:	631/337/475 631/378/1689/1718 692/617/375/346/1718 82/58 Aged Biomarkers Biomarkers - blood Blood Case-Control Studies Clinical trials Complement component C3 Female Granulin Humanities and Social Sciences Humans Inhibitors Machine Learning Male Mannan Mass Spectrometry Mass spectroscopy Middle Aged multidisciplinary Neurodegenerative diseases Parkinson Disease - blood Parkinson Disease - diagnosis Parkinson's disease Proteinase inhibitors Proteomics Proteomics - methods REM sleep REM Sleep Behavior Disorder - blood REM Sleep Behavior Disorder - diagnosis Science Science (multidisciplinary) Signal transduction Signs and symptoms Sleep Sleep disorders Wnt protein
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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