Targeting replication stress in cancer therapy

Replication stress is a major cause of genomic instability and a crucial vulnerability of cancer cells. This vulnerability can be therapeutically targeted by inhibiting kinases that coordinate the DNA damage response with cell cycle control, including ATR, CHK1, WEE1 and MYT1 checkpoint kinases. In...

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Bibliographic Details

Published in:	Nature reviews. Drug discovery Vol. 22; no. 1; pp. 38 - 58
Main Authors:	da Costa, Alexandre André B A, Chowdhury, Dipanjan, Shapiro, Geoffrey I, D'Andrea, Alan D, Konstantinopoulos, Panagiotis A
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.01.2023
Subjects:	Cancer Cell cycle Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Cycle Proteins - therapeutic use Checkpoint Kinase 1 - genetics Checkpoint Kinase 1 - metabolism Checkpoint Kinase 1 - therapeutic use Chemotherapy DNA Damage DNA Replication Humans Immune checkpoint inhibitors Neoplasms - drug therapy Neoplasms - genetics
ISSN:	1474-1776, 1474-1784, 1474-1784
Online Access:	Get full text
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