Inflammatory and neurodegenerative serum protein biomarkers increase sensitivity to detect clinical and radiographic disease activity in multiple sclerosis

The multifaceted nature of multiple sclerosis requires quantitative biomarkers that can provide insights related to diverse physiological pathways. To this end, proteomic analysis of deeply-phenotyped serum samples, biological pathway modeling, and network analysis were performed to elucidate inflam...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 4297 - 12
Main Authors:	Chitnis, Tanuja, Qureshi, Ferhan, Gehman, Victor M., Becich, Michael, Bove, Riley, Cree, Bruce A. C., Gomez, Refujia, Hauser, Stephen L., Henry, Roland G., Katrib, Amal, Lokhande, Hrishikesh, Paul, Anu, Caillier, Stacy J., Santaniello, Adam, Sattarnezhad, Neda, Saxena, Shrishti, Weiner, Howard, Yano, Hajime, Baranzini, Sergio E.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 20.05.2024 Nature Publishing Group Nature Portfolio
Subjects:	49 631/378/1689/1666 692/53/2421 692/617/375/1666 82/80 Adult Autoimmune diseases Biomarkers Biomarkers - blood Blood Proteins - analysis Cohort Studies Female Gadolinium Humanities and Social Sciences Humans Inflammation Inflammation - blood Magnetic Resonance Imaging - methods Male Middle Aged Modelling multidisciplinary Multiple sclerosis Multiple Sclerosis - blood Multiple Sclerosis - diagnostic imaging Network analysis Neurofilament Proteins - blood Proteins Proteomics Proteomics - methods Science Science (multidisciplinary) Serum proteins
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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