Nuclear actin polymerization rapidly mediates replication fork remodeling upon stress by limiting PrimPol activity

Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replication fork plasticity is achieved in the context of nuclear organization is currently unknown. Using nuclear actin probes in living and fixed cells, we visualized nuclear actin filamen...

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Veröffentlicht in:	Nature communications Jg. 14; H. 1; S. 7819 - 15
Hauptverfasser:	Palumbieri, Maria Dilia, Merigliano, Chiara, González-Acosta, Daniel, Kuster, Danina, Krietsch, Jana, Stoy, Henriette, von Känel, Thomas, Ulferts, Svenja, Welter, Bettina, Frey, Joël, Doerdelmann, Cyril, Sanchi, Andrea, Grosse, Robert, Chiolo, Irene, Lopes, Massimo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 28.11.2023 Nature Publishing Group Nature Portfolio
Schlagworte:	13 14 14/1 14/19 14/28 631/337/1427/2566 631/337/151/2356 Actin Actins - genetics Cell Line, Tumor Chromatin Chromosomes Constraining Deoxyribonucleic acid Deregulation DNA DNA - genetics DNA biosynthesis DNA damage DNA probes DNA Replication Filaments Genomic instability Genotoxicity Humanities and Social Sciences multidisciplinary Plastic foam Plastic properties Plasticity Polymerization Replication S phase Science Science (multidisciplinary)
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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