Nuclear actin polymerization rapidly mediates replication fork remodeling upon stress by limiting PrimPol activity

Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replication fork plasticity is achieved in the context of nuclear organization is currently unknown. Using nuclear actin probes in living and fixed cells, we visualized nuclear actin filamen...

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Vydáno v:Nature communications Ročník 14; číslo 1; s. 7819 - 15
Hlavní autoři: Palumbieri, Maria Dilia, Merigliano, Chiara, González-Acosta, Daniel, Kuster, Danina, Krietsch, Jana, Stoy, Henriette, von Känel, Thomas, Ulferts, Svenja, Welter, Bettina, Frey, Joël, Doerdelmann, Cyril, Sanchi, Andrea, Grosse, Robert, Chiolo, Irene, Lopes, Massimo
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 28.11.2023
Nature Publishing Group
Nature Portfolio
Témata:
13
14
14/1
14/19
14/28
631/337/1427/2566
631/337/151/2356
Actin
Actins - genetics
Cell Line, Tumor
Chromatin
Chromosomes
Constraining
Deoxyribonucleic acid
Deregulation
DNA
DNA - genetics
DNA biosynthesis
DNA damage
DNA probes
DNA Replication
Filaments
Genomic instability
Genotoxicity
Humanities and Social Sciences
multidisciplinary
Plastic foam
Plastic properties
Plasticity
Polymerization
Replication
S phase
Science
Science (multidisciplinary)
ISSN:2041-1723, 2041-1723
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Abstract Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replication fork plasticity is achieved in the context of nuclear organization is currently unknown. Using nuclear actin probes in living and fixed cells, we visualized nuclear actin filaments in unperturbed S phase and observed their rapid extension in number and length upon genotoxic treatments, frequently taking contact with replication factories. Chemically or genetically impairing nuclear actin polymerization shortly before these treatments prevents active fork slowing and abolishes fork reversal. Defective fork remodeling is linked to deregulated chromatin loading of PrimPol, which promotes unrestrained and discontinuous DNA synthesis and limits the recruitment of RAD51 and SMARCAL1 to nascent DNA. Moreover, defective nuclear actin polymerization upon mild replication interference induces chromosomal instability in a PRIMPOL-dependent manner. Hence, by limiting PrimPol activity, nuclear F-actin orchestrates replication fork plasticity and is a key molecular determinant in the rapid cellular response to genotoxic treatments. How nuclear architecture assists the replication stress response is still largely unknown. Here the authors show that nuclear actin polymerization rapidly extends upon mild DNA damage. By limiting Primpol activity, this response mediates fork slowing and reversal, protecting chromosome stability.
AbstractList Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replication fork plasticity is achieved in the context of nuclear organization is currently unknown. Using nuclear actin probes in living and fixed cells, we visualized nuclear actin filaments in unperturbed S phase and observed their rapid extension in number and length upon genotoxic treatments, frequently taking contact with replication factories. Chemically or genetically impairing nuclear actin polymerization shortly before these treatments prevents active fork slowing and abolishes fork reversal. Defective fork remodeling is linked to deregulated chromatin loading of PrimPol, which promotes unrestrained and discontinuous DNA synthesis and limits the recruitment of RAD51 and SMARCAL1 to nascent DNA. Moreover, defective nuclear actin polymerization upon mild replication interference induces chromosomal instability in a PRIMPOL-dependent manner. Hence, by limiting PrimPol activity, nuclear F-actin orchestrates replication fork plasticity and is a key molecular determinant in the rapid cellular response to genotoxic treatments.
Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replication fork plasticity is achieved in the context of nuclear organization is currently unknown. Using nuclear actin probes in living and fixed cells, we visualized nuclear actin filaments in unperturbed S phase and observed their rapid extension in number and length upon genotoxic treatments, frequently taking contact with replication factories. Chemically or genetically impairing nuclear actin polymerization shortly before these treatments prevents active fork slowing and abolishes fork reversal. Defective fork remodeling is linked to deregulated chromatin loading of PrimPol, which promotes unrestrained and discontinuous DNA synthesis and limits the recruitment of RAD51 and SMARCAL1 to nascent DNA. Moreover, defective nuclear actin polymerization upon mild replication interference induces chromosomal instability in a PRIMPOL-dependent manner. Hence, by limiting PrimPol activity, nuclear F-actin orchestrates replication fork plasticity and is a key molecular determinant in the rapid cellular response to genotoxic treatments.Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replication fork plasticity is achieved in the context of nuclear organization is currently unknown. Using nuclear actin probes in living and fixed cells, we visualized nuclear actin filaments in unperturbed S phase and observed their rapid extension in number and length upon genotoxic treatments, frequently taking contact with replication factories. Chemically or genetically impairing nuclear actin polymerization shortly before these treatments prevents active fork slowing and abolishes fork reversal. Defective fork remodeling is linked to deregulated chromatin loading of PrimPol, which promotes unrestrained and discontinuous DNA synthesis and limits the recruitment of RAD51 and SMARCAL1 to nascent DNA. Moreover, defective nuclear actin polymerization upon mild replication interference induces chromosomal instability in a PRIMPOL-dependent manner. Hence, by limiting PrimPol activity, nuclear F-actin orchestrates replication fork plasticity and is a key molecular determinant in the rapid cellular response to genotoxic treatments.
Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replication fork plasticity is achieved in the context of nuclear organization is currently unknown. Using nuclear actin probes in living and fixed cells, we visualized nuclear actin filaments in unperturbed S phase and observed their rapid extension in number and length upon genotoxic treatments, frequently taking contact with replication factories. Chemically or genetically impairing nuclear actin polymerization shortly before these treatments prevents active fork slowing and abolishes fork reversal. Defective fork remodeling is linked to deregulated chromatin loading of PrimPol, which promotes unrestrained and discontinuous DNA synthesis and limits the recruitment of RAD51 and SMARCAL1 to nascent DNA. Moreover, defective nuclear actin polymerization upon mild replication interference induces chromosomal instability in a PRIMPOL-dependent manner. Hence, by limiting PrimPol activity, nuclear F-actin orchestrates replication fork plasticity and is a key molecular determinant in the rapid cellular response to genotoxic treatments.How nuclear architecture assists the replication stress response is still largely unknown. Here the authors show that nuclear actin polymerization rapidly extends upon mild DNA damage. By limiting Primpol activity, this response mediates fork slowing and reversal, protecting chromosome stability.
Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replication fork plasticity is achieved in the context of nuclear organization is currently unknown. Using nuclear actin probes in living and fixed cells, we visualized nuclear actin filaments in unperturbed S phase and observed their rapid extension in number and length upon genotoxic treatments, frequently taking contact with replication factories. Chemically or genetically impairing nuclear actin polymerization shortly before these treatments prevents active fork slowing and abolishes fork reversal. Defective fork remodeling is linked to deregulated chromatin loading of PrimPol, which promotes unrestrained and discontinuous DNA synthesis and limits the recruitment of RAD51 and SMARCAL1 to nascent DNA. Moreover, defective nuclear actin polymerization upon mild replication interference induces chromosomal instability in a PRIMPOL-dependent manner. Hence, by limiting PrimPol activity, nuclear F-actin orchestrates replication fork plasticity and is a key molecular determinant in the rapid cellular response to genotoxic treatments. How nuclear architecture assists the replication stress response is still largely unknown. Here the authors show that nuclear actin polymerization rapidly extends upon mild DNA damage. By limiting Primpol activity, this response mediates fork slowing and reversal, protecting chromosome stability.
Abstract Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replication fork plasticity is achieved in the context of nuclear organization is currently unknown. Using nuclear actin probes in living and fixed cells, we visualized nuclear actin filaments in unperturbed S phase and observed their rapid extension in number and length upon genotoxic treatments, frequently taking contact with replication factories. Chemically or genetically impairing nuclear actin polymerization shortly before these treatments prevents active fork slowing and abolishes fork reversal. Defective fork remodeling is linked to deregulated chromatin loading of PrimPol, which promotes unrestrained and discontinuous DNA synthesis and limits the recruitment of RAD51 and SMARCAL1 to nascent DNA. Moreover, defective nuclear actin polymerization upon mild replication interference induces chromosomal instability in a PRIMPOL-dependent manner. Hence, by limiting PrimPol activity, nuclear F-actin orchestrates replication fork plasticity and is a key molecular determinant in the rapid cellular response to genotoxic treatments.
ArticleNumber 7819
Author González-Acosta, Daniel
Stoy, Henriette
Krietsch, Jana
Doerdelmann, Cyril
Frey, Joël
von Känel, Thomas
Ulferts, Svenja
Sanchi, Andrea
Chiolo, Irene
Palumbieri, Maria Dilia
Merigliano, Chiara
Grosse, Robert
Lopes, Massimo
Kuster, Danina
Welter, Bettina
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/38016948$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/j.molcel.2013.10.035
10.1038/ncb2364
10.15252/embj.201796585
10.1016/j.molcel.2017.11.022
10.1091/mbc.02-05-0068
10.3389/fgene.2021.773426
10.1016/j.molcel.2017.08.010
10.1007/978-1-0716-2477-7_1
10.1038/ncb2472
10.3389/fgene.2018.00398
10.1038/ncb3641
10.7554/eLife.07735
10.1038/s41467-023-39517-y
10.1038/s41586-018-0261-5
10.1101/gad.2053211
10.1016/j.molcel.2021.09.013
10.1016/j.molcel.2022.09.009
10.3390/genes8010020
10.1146/annurev-pathol-012414-040424
10.1074/jbc.M114.627166
10.1038/s41467-020-17324-z
10.1038/s41586-018-0242-8
10.1016/j.celrep.2018.08.019
10.1093/nar/gkad369
10.1038/s41556-020-00605-6
10.1007/978-1-0716-0644-5_32
10.1038/s41467-017-01164-5
10.1126/sciadv.ade7997
10.1126/science.1235038
10.1016/j.trecan.2020.10.010
10.1016/bs.mie.2017.11.033
10.1083/jcb.201106022
10.1016/j.molcel.2022.05.004
10.1038/s41467-019-13322-y
10.1038/nsmb.3387
10.1101/gad.256404.114
10.1016/j.tcb.2019.02.010
10.1126/science.add7328
10.1038/s41467-020-19570-7
10.1083/jcb.201406099
10.1007/s00418-013-1151-4
10.1083/jcb.140.6.1285
10.1038/s41467-018-05009-7
10.1242/jcs.204487
10.1101/gad.178459.111
10.1038/s41467-017-01180-5
10.1038/nature18325
10.1126/science.1162790
10.1016/bs.mie.2017.03.019
10.1016/j.cell.2014.08.030
10.1038/s41556-019-0379-1
10.1038/s41467-022-31415-z
10.1038/s41467-017-01805-9
10.1016/j.semcdb.2019.10.012
10.1038/nrm3935
10.15252/embj.2020106355
10.1038/ncb2465
10.1038/nsmb.2719
10.1016/j.molcel.2019.10.008
10.1038/ncomms15222
10.1016/j.pharmthera.2018.03.005
10.1038/s41586-018-0237-5
10.1016/j.tcb.2021.06.002
10.1038/nsmb.2501
10.1038/s41467-021-26227-6
10.1126/sciadv.abm0314
10.1038/s41556-023-01167-z
10.1093/nar/gkac583
10.1126/sciimmunol.aav1987
10.1016/j.molcel.2020.04.031
10.1038/s41579-020-0407-y
10.1038/s41586-023-05981-1
10.1016/j.chembiol.2013.03.019
10.1007/s00412-023-00813-7
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References Vujanovic (CR9) 2017; 67
Hurst, Shimada, Gasser (CR29) 2019; 29
Berti (CR65) 2020; 11
Mutreja (CR24) 2018; 24
Jacobs (CR23) 2022; 82
Lemacon (CR14) 2017; 8
CR37
Macheret, Halazonetis (CR2) 2015; 10
Plessner, Melak, Chinchilla, Baarlink, Grosse (CR35) 2015; 290
Klages-Mundt, Kumar, Zhang, Kapoor, Shen (CR27) 2018; 09
Wang (CR56) 2017; 8
González‐Acosta (CR20) 2021; 40
Mehta (CR61) 2022; 8
Han (CR45) 2022; 13
Caridi, Plessner, Grosse, Chiolo (CR32) 2019; 21
Zellweger (CR11) 2015; 208
Berti (CR57) 2013; 20
Mansilla (CR62) 2023; 9
Caridi (CR40) 2018; 559
Shi (CR47) 2023; 14
Mijic (CR13) 2017; 8
Aymard (CR41) 2017; 24
de Lanerolle, Serebryannyy (CR30) 2011; 13
Piberger (CR19) 2020; 11
Baarlink, Wang, Grosse (CR34) 2013; 340
Su, Dion, Gasser, Freudenreich (CR69) 2015; 29
Caridi (CR76) 2018; 601
Guilliam (CR64) 2017; 8
See, Arya, Lin, Chiolo (CR75) 2020; 2153
Betous (CR8) 2012; 26
Bianchi (CR18) 2013; 52
Quinet (CR22) 2020; 77
Dion, Kalck, Horigome, Towbin, Gasser (CR71) 2012; 14
Neelsen, Lopes (CR6) 2015; 16
Forment, O’Connor (CR3) 2018; 188
Quinet, Lemacon, Vindigni (CR7) 2017; 68
Oshidari (CR73) 2018; 9
Wang (CR36) 2019; 10
Wynne, Rog, Carlton, Dernburg (CR67) 2012; 196
CR10
CR54
Parisis (CR43) 2017; 36
CR53
Baillie, Stirling (CR4) 2021; 7
Mourón (CR17) 2013; 20
Tirman (CR21) 2021; 81
Saxena, Zou (CR1) 2022; 82
CR51
Kokai (CR49) 2014; 141
Kang (CR59) 2021; 12
Miné-Hattab, Rothstein (CR72) 2012; 14
Chaudhuri (CR15) 2016; 535
Quinet, Carvajal-Maldonado, Lemacon, Vindigni (CR60) 2017; 591
Lamm (CR44) 2020; 22
Melak, Plessner, Grosse (CR31) 2017; 130
Posern, Sotiropoulos, Treisman (CR48) 2002; 13
Guilliam, Doherty (CR16) 2017; 8
Kyheröinen, Vartiainen (CR74) 2020; 102
Lamm, Rogers, Cesare (CR33) 2021; 31
Wootton, Soutoglou (CR25) 2021; 12
Cho, Dilley, Lampson, Greenberg (CR70) 2014; 159
CR26
Belin, Lee, Mullins (CR39) 2015; 4
Gaggioli (CR66) 2023; 25
Liu (CR12) 2023; 380
Ulferts, Prajapati, Grosse, Vartiainen (CR28) 2021; 13
Baarlink (CR38) 2017; 19
Stoy (CR55) 2022; 2528
Maya-Mendoza (CR58) 2018; 559
CR63
Jackson, Pombo (CR52) 1998; 140
Nieminuszczy (CR46) 2023; 51
Sirbu (CR50) 2011; 25
Schrank (CR42) 2018; 559
Nagai (CR68) 2008; 322
Berti, Cortez, Lopes (CR5) 2020; 18
43183_CR26
CP Caridi (43183_CR76) 2018; 601
J Shi (43183_CR47) 2023; 14
A Quinet (43183_CR60) 2017; 591
BJ Belin (43183_CR39) 2015; 4
M Berti (43183_CR5) 2020; 18
D Lemacon (43183_CR14) 2017; 8
N Lamm (43183_CR44) 2020; 22
KPM Mehta (43183_CR61) 2022; 8
BR Schrank (43183_CR42) 2018; 559
A Quinet (43183_CR22) 2020; 77
H Stoy (43183_CR55) 2022; 2528
M Plessner (43183_CR35) 2015; 290
BM Sirbu (43183_CR50) 2011; 25
W Liu (43183_CR12) 2023; 380
P de Lanerolle (43183_CR30) 2011; 13
J Bianchi (43183_CR18) 2013; 52
JV Forment (43183_CR3) 2018; 188
S Kyheröinen (43183_CR74) 2020; 102
C Baarlink (43183_CR34) 2013; 340
43183_CR10
43183_CR54
S Saxena (43183_CR1) 2022; 82
C Baarlink (43183_CR38) 2017; 19
CP Caridi (43183_CR40) 2018; 559
N Parisis (43183_CR43) 2017; 36
KE Baillie (43183_CR4) 2021; 7
CP Caridi (43183_CR32) 2019; 21
S Mourón (43183_CR17) 2013; 20
D González‐Acosta (43183_CR20) 2021; 40
R Betous (43183_CR8) 2012; 26
F Aymard (43183_CR41) 2017; 24
Z Kang (43183_CR59) 2021; 12
S Ulferts (43183_CR28) 2021; 13
K Jacobs (43183_CR23) 2022; 82
Y Wang (43183_CR36) 2019; 10
S Tirman (43183_CR21) 2021; 81
43183_CR63
M Vujanovic (43183_CR9) 2017; 67
M Melak (43183_CR31) 2017; 130
C See (43183_CR75) 2020; 2153
S-S Han (43183_CR45) 2022; 13
M Macheret (43183_CR2) 2015; 10
M Berti (43183_CR65) 2020; 11
XA Su (43183_CR69) 2015; 29
V Hurst (43183_CR29) 2019; 29
M Berti (43183_CR57) 2013; 20
AL Piberger (43183_CR19) 2020; 11
E Kokai (43183_CR49) 2014; 141
43183_CR51
43183_CR53
R Zellweger (43183_CR11) 2015; 208
S Nagai (43183_CR68) 2008; 322
S Mijic (43183_CR13) 2017; 8
J Miné-Hattab (43183_CR72) 2012; 14
43183_CR37
R Oshidari (43183_CR73) 2018; 9
J Nieminuszczy (43183_CR46) 2023; 51
NW Cho (43183_CR70) 2014; 159
K Mutreja (43183_CR24) 2018; 24
AR Chaudhuri (43183_CR15) 2016; 535
V Dion (43183_CR71) 2012; 14
J Wootton (43183_CR25) 2021; 12
A Quinet (43183_CR7) 2017; 68
TA Guilliam (43183_CR64) 2017; 8
Y-H Wang (43183_CR56) 2017; 8
NL Klages-Mundt (43183_CR27) 2018; 09
G Posern (43183_CR48) 2002; 13
A Maya-Mendoza (43183_CR58) 2018; 559
KJ Neelsen (43183_CR6) 2015; 16
SF Mansilla (43183_CR62) 2023; 9
DJ Wynne (43183_CR67) 2012; 196
TA Guilliam (43183_CR16) 2017; 8
DA Jackson (43183_CR52) 1998; 140
N Lamm (43183_CR33) 2021; 31
V Gaggioli (43183_CR66) 2023; 25
36993227 - bioRxiv. 2023 Mar 25:2023.03.24.534097. doi: 10.1101/2023.03.24.534097.
References_xml – volume: 52
  start-page: 566
  year: 2013
  end-page: 573
  ident: CR18
  article-title: PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2013.10.035
– volume: 13
  start-page: 1282
  year: 2011
  end-page: 1288
  ident: CR30
  article-title: Nuclear actin and myosins: life without filaments
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2364
– volume: 36
  start-page: 3212
  year: 2017
  end-page: 3231
  ident: CR43
  article-title: Initiation of DNA replication requires actin dynamics and formin activity
  publication-title: EMBO J.
  doi: 10.15252/embj.201796585
– volume: 68
  start-page: 830
  year: 2017
  end-page: 833
  ident: CR7
  article-title: Replication fork reversal: players and guardians
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2017.11.022
– volume: 18
  start-page: 622
  year: 2020
  end-page: 19
  ident: CR5
  article-title: The plasticity of DNA replication forks in response to clinically relevant genotoxic stress
  publication-title: Nat. Rev. Mol. Cell Biol.
– volume: 13
  start-page: 4167
  year: 2002
  end-page: 4178
  ident: CR48
  article-title: Mutant actins demonstrate a role for unpolymerized actin in control of transcription by serum response factor
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.02-05-0068
– volume: 12
  start-page: 773426
  year: 2021
  ident: CR25
  article-title: Chromatin and nuclear dynamics in the maintenance of replication fork integrity
  publication-title: Front. Genet.
  doi: 10.3389/fgene.2021.773426
– ident: CR51
– volume: 67
  start-page: 882
  year: 2017
  end-page: 890.e5
  ident: CR9
  article-title: Replication fork slowing and reversal upon DNA damage require PCNA polyubiquitination and ZRANB3 DNA translocase activity
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2017.08.010
– volume: 2528
  start-page: 1
  year: 2022
  end-page: 20
  ident: CR55
  article-title: R-Loops, methods and protocols
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-0716-2477-7_1
– volume: 14
  start-page: 510
  year: 2012
  end-page: 517
  ident: CR72
  article-title: Increased chromosome mobility facilitates homology search during recombination
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2472
– volume: 09
  start-page: 398
  year: 2018
  ident: CR27
  article-title: The nature of actin-family proteins in chromatin-modifying complexes
  publication-title: Front. Genet.
  doi: 10.3389/fgene.2018.00398
– volume: 19
  start-page: 1389
  year: 2017
  end-page: 1399
  ident: CR38
  article-title: A transient pool of nuclear F-actin at mitotic exit controls chromatin organization
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3641
– volume: 4
  start-page: e07735
  year: 2015
  ident: CR39
  article-title: DNA damage induces nuclear actin filament assembly by Formin-2 and Spire-1/2 that promotes efficient DNA repair
  publication-title: Elife
  doi: 10.7554/eLife.07735
– ident: CR54
– volume: 14
  year: 2023
  ident: CR47
  article-title: Nuclear myosin VI maintains replication fork stability
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-023-39517-y
– volume: 559
  start-page: 279
  year: 2018
  end-page: 284
  ident: CR58
  article-title: High speed of fork progression induces DNA replication stress and genomic instability
  publication-title: Nature
  doi: 10.1038/s41586-018-0261-5
– volume: 25
  start-page: 1320
  year: 2011
  end-page: 1327
  ident: CR50
  article-title: Analysis of protein dynamics at active, stalled, and collapsed replication forks
  publication-title: Genes Dev.
  doi: 10.1101/gad.2053211
– volume: 81
  start-page: 4026
  year: 2021
  end-page: 4040.e8
  ident: CR21
  article-title: Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2021.09.013
– volume: 82
  start-page: 4176
  year: 2022
  end-page: 4188.e8
  ident: CR23
  article-title: Stress-triggered hematopoietic stem cell proliferation relies on PrimPol-mediated repriming
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2022.09.009
– volume: 8
  start-page: 20
  year: 2017
  ident: CR16
  article-title: PrimPol-prime time to reprime
  publication-title: Genes
  doi: 10.3390/genes8010020
– volume: 10
  start-page: 425
  year: 2015
  end-page: 448
  ident: CR2
  article-title: DNA replication stress as a hallmark of cancer
  publication-title: Annu. Rev. Pathol.
  doi: 10.1146/annurev-pathol-012414-040424
– volume: 290
  start-page: 11209
  year: 2015
  end-page: 11216
  ident: CR35
  article-title: Nuclear F-actin formation and reorganization upon cell spreading
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M114.627166
– volume: 11
  year: 2020
  ident: CR65
  article-title: Sequential role of RAD51 paralog complexes in replication fork remodeling and restart
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-17324-z
– volume: 559
  start-page: 54
  year: 2018
  end-page: 60
  ident: CR40
  article-title: Nuclear F-actin and myosins drive relocalization of heterochromatic breaks
  publication-title: Nature
  doi: 10.1038/s41586-018-0242-8
– volume: 24
  start-page: 2629
  year: 2018
  end-page: 2642.e5
  ident: CR24
  article-title: ATR-mediated global fork slowing and reversal assist fork traverse and prevent chromosomal breakage at DNA interstrand cross-links
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2018.08.019
– volume: 51
  start-page: 6337
  year: 2023
  end-page: 6354
  ident: CR46
  article-title: Actin nucleators safeguard replication forks by limiting nascent strand degradation
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkad369
– volume: 22
  start-page: 1460
  year: 2020
  end-page: 1470
  ident: CR44
  article-title: Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stress
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-020-00605-6
– volume: 2153
  start-page: 459
  year: 2020
  end-page: 482
  ident: CR75
  article-title: Live cell imaging of nuclear actin filaments and heterochromatic repair foci in drosophila and mouse cells
  publication-title: Methods Mol. Biol. Clifton N J.
  doi: 10.1007/978-1-0716-0644-5_32
– volume: 8
  year: 2017
  ident: CR13
  article-title: Replication fork reversal triggers fork degradation in BRCA2-defective cells
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-01164-5
– volume: 9
  start-page: eade7997
  year: 2023
  ident: CR62
  article-title: Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.ade7997
– volume: 340
  start-page: 864
  year: 2013
  end-page: 867
  ident: CR34
  article-title: Nuclear actin network assembly by formins regulates the SRF coactivator MAL
  publication-title: Science
  doi: 10.1126/science.1235038
– volume: 7
  start-page: 430
  year: 2021
  end-page: 446
  ident: CR4
  article-title: Beyond kinases: targeting replication stress proteins in cancer Therapy
  publication-title: Trends Cancer
  doi: 10.1016/j.trecan.2020.10.010
– ident: CR26
– volume: 601
  start-page: 359
  year: 2018
  end-page: 389
  ident: CR76
  article-title: Quantitative methods to investigate the 4D dynamics of heterochromatic repair sites in Drosophila cells
  publication-title: Methods Enzymol.
  doi: 10.1016/bs.mie.2017.11.033
– volume: 196
  start-page: 47
  year: 2012
  end-page: 64
  ident: CR67
  article-title: Dynein-dependent processive chromosome motions promote homologous pairing in meiosis
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201106022
– volume: 82
  start-page: 2298
  year: 2022
  end-page: 2314
  ident: CR1
  article-title: Hallmarks of DNA replication stress
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2022.05.004
– volume: 10
  year: 2019
  ident: CR36
  article-title: GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-13322-y
– ident: CR37
– volume: 24
  start-page: 353
  year: 2017
  end-page: 361
  ident: CR41
  article-title: Genome wide mapping of long range contacts unveils DNA Double Strand Breaks clustering at damaged active genes
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.3387
– ident: CR53
– volume: 29
  start-page: 1006
  year: 2015
  end-page: 1017
  ident: CR69
  article-title: Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability
  publication-title: Gene Dev.
  doi: 10.1101/gad.256404.114
– volume: 29
  start-page: 462
  year: 2019
  end-page: 476
  ident: CR29
  article-title: Nuclear actin and actin-binding proteins in DNA repair
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2019.02.010
– ident: CR10
– volume: 380
  start-page: 382
  year: 2023
  end-page: 387
  ident: CR12
  article-title: RAD51 bypasses the CMG helicase to promote replication fork reversal
  publication-title: Science
  doi: 10.1126/science.add7328
– volume: 11
  year: 2020
  ident: CR19
  article-title: PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-19570-7
– volume: 208
  start-page: 563
  year: 2015
  end-page: 579
  ident: CR11
  article-title: Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201406099
– volume: 141
  start-page: 123
  year: 2014
  end-page: 135
  ident: CR49
  article-title: Analysis of nuclear actin by overexpression of wild-type and actin mutant proteins
  publication-title: Histochem. Cell Biol.
  doi: 10.1007/s00418-013-1151-4
– volume: 140
  start-page: 1285
  year: 1998
  end-page: 1295
  ident: CR52
  article-title: Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.140.6.1285
– volume: 9
  year: 2018
  ident: CR73
  article-title: Nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote DNA repair
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-05009-7
– ident: CR63
– volume: 130
  start-page: 525
  year: 2017
  end-page: 530
  ident: CR31
  article-title: Actin visualization at a glance
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.204487
– volume: 26
  start-page: 151
  year: 2012
  end-page: 162
  ident: CR8
  article-title: SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication
  publication-title: Genes Dev.
  doi: 10.1101/gad.178459.111
– volume: 8
  year: 2017
  ident: CR14
  article-title: MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-01180-5
– volume: 535
  start-page: 382
  year: 2016
  end-page: 387
  ident: CR15
  article-title: Replication fork stability confers chemoresistance in BRCA-deficient cells
  publication-title: Nature
  doi: 10.1038/nature18325
– volume: 322
  start-page: 597
  year: 2008
  end-page: 602
  ident: CR68
  article-title: Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase
  publication-title: Science
  doi: 10.1126/science.1162790
– volume: 13
  start-page: a040121
  year: 2021
  ident: CR28
  article-title: Emerging properties and functions of actin and actin filaments inside the nucleus
  publication-title: CSH Perspect. Biol.
– volume: 591
  start-page: 55
  year: 2017
  end-page: 82
  ident: CR60
  article-title: DNA fiber analysis: mind the gap!
  publication-title: Methods Enzymol.
  doi: 10.1016/bs.mie.2017.03.019
– volume: 159
  start-page: 108
  year: 2014
  end-page: 121
  ident: CR70
  article-title: Interchromosomal homology searches drive directional ALT telomere movement and synapsis
  publication-title: Cell
  doi: 10.1016/j.cell.2014.08.030
– volume: 21
  start-page: 1068
  year: 2019
  end-page: 1077
  ident: CR32
  article-title: Nuclear actin filaments in DNA repair dynamics
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-019-0379-1
– volume: 13
  year: 2022
  ident: CR45
  article-title: WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-022-31415-z
– volume: 8
  year: 2017
  ident: CR56
  article-title: DNA damage causes rapid accumulation of phosphoinositides for ATR signaling
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-01805-9
– volume: 102
  start-page: 105
  year: 2020
  end-page: 112
  ident: CR74
  article-title: Nuclear actin dynamics in gene expression and genome organization
  publication-title: Semin. Cell Dev. Biol.
  doi: 10.1016/j.semcdb.2019.10.012
– volume: 16
  start-page: 207
  year: 2015
  end-page: 220
  ident: CR6
  article-title: Replication fork reversal in eukaryotes: from dead end to dynamic response
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3935
– volume: 40
  start-page: e106355
  year: 2021
  ident: CR20
  article-title: PrimPol‐mediated repriming facilitates replication traverse of DNA interstrand crosslinks
  publication-title: EMBO J.
  doi: 10.15252/embj.2020106355
– volume: 14
  start-page: 502
  year: 2012
  end-page: 509
  ident: CR71
  article-title: Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2465
– volume: 20
  start-page: 1383
  year: 2013
  end-page: 1389
  ident: CR17
  article-title: Repriming of DNA synthesis at stalled replication forks by human PrimPol
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.2719
– volume: 77
  start-page: 461
  year: 2020
  end-page: 474.e9
  ident: CR22
  article-title: PRIMPOL-mediated adaptive response suppresses replication fork reversal in BRCA-deficient cells
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2019.10.008
– volume: 8
  start-page: 15222
  year: 2017
  end-page: 14
  ident: CR64
  article-title: Molecular basis for PrimPol recruitment to replication forks by RPA
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms15222
– volume: 188
  start-page: 155
  year: 2018
  end-page: 167
  ident: CR3
  article-title: Targeting the replication stress response in cancer
  publication-title: Pharmacol. Ther.
  doi: 10.1016/j.pharmthera.2018.03.005
– volume: 559
  start-page: 61
  year: 2018
  end-page: 66
  ident: CR42
  article-title: Nuclear Arp2/3 drives DNA break clustering for homology-directed repair
  publication-title: Nature
  doi: 10.1038/s41586-018-0237-5
– volume: 31
  start-page: 843
  year: 2021
  end-page: 855
  ident: CR33
  article-title: Chromatin mobility and relocation in DNA repair
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2021.06.002
– volume: 20
  start-page: 347
  year: 2013
  end-page: 354
  ident: CR57
  article-title: Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.2501
– volume: 12
  year: 2021
  ident: CR59
  article-title: BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-26227-6
– volume: 8
  start-page: eabm0314
  year: 2022
  ident: CR61
  article-title: CHK1 phosphorylates PRIMPOL to promote replication stress tolerance
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.abm0314
– volume: 25
  start-page: 1017
  year: 2023
  end-page: 1032
  ident: CR66
  article-title: Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-023-01167-z
– volume: 9
  year: 2018
  ident: 43183_CR73
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-05009-7
– ident: 43183_CR54
  doi: 10.1093/nar/gkac583
– volume: 29
  start-page: 1006
  year: 2015
  ident: 43183_CR69
  publication-title: Gene Dev.
  doi: 10.1101/gad.256404.114
– volume: 77
  start-page: 461
  year: 2020
  ident: 43183_CR22
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2019.10.008
– volume: 22
  start-page: 1460
  year: 2020
  ident: 43183_CR44
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-020-00605-6
– volume: 67
  start-page: 882
  year: 2017
  ident: 43183_CR9
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2017.08.010
– ident: 43183_CR37
  doi: 10.1126/sciimmunol.aav1987
– volume: 559
  start-page: 61
  year: 2018
  ident: 43183_CR42
  publication-title: Nature
  doi: 10.1038/s41586-018-0237-5
– volume: 559
  start-page: 279
  year: 2018
  ident: 43183_CR58
  publication-title: Nature
  doi: 10.1038/s41586-018-0261-5
– volume: 51
  start-page: 6337
  year: 2023
  ident: 43183_CR46
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkad369
– volume: 2528
  start-page: 1
  year: 2022
  ident: 43183_CR55
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-0716-2477-7_1
– volume: 14
  start-page: 502
  year: 2012
  ident: 43183_CR71
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2465
– volume: 8
  year: 2017
  ident: 43183_CR56
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-01805-9
– volume: 82
  start-page: 4176
  year: 2022
  ident: 43183_CR23
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2022.09.009
– volume: 2153
  start-page: 459
  year: 2020
  ident: 43183_CR75
  publication-title: Methods Mol. Biol. Clifton N J.
  doi: 10.1007/978-1-0716-0644-5_32
– volume: 188
  start-page: 155
  year: 2018
  ident: 43183_CR3
  publication-title: Pharmacol. Ther.
  doi: 10.1016/j.pharmthera.2018.03.005
– volume: 7
  start-page: 430
  year: 2021
  ident: 43183_CR4
  publication-title: Trends Cancer
  doi: 10.1016/j.trecan.2020.10.010
– volume: 11
  year: 2020
  ident: 43183_CR19
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-19570-7
– volume: 21
  start-page: 1068
  year: 2019
  ident: 43183_CR32
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-019-0379-1
– volume: 20
  start-page: 1383
  year: 2013
  ident: 43183_CR17
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.2719
– volume: 31
  start-page: 843
  year: 2021
  ident: 43183_CR33
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2021.06.002
– volume: 12
  year: 2021
  ident: 43183_CR59
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-26227-6
– volume: 24
  start-page: 2629
  year: 2018
  ident: 43183_CR24
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2018.08.019
– ident: 43183_CR10
  doi: 10.1016/j.molcel.2020.04.031
– volume: 591
  start-page: 55
  year: 2017
  ident: 43183_CR60
  publication-title: Methods Enzymol.
  doi: 10.1016/bs.mie.2017.03.019
– volume: 14
  start-page: 510
  year: 2012
  ident: 43183_CR72
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2472
– volume: 535
  start-page: 382
  year: 2016
  ident: 43183_CR15
  publication-title: Nature
  doi: 10.1038/nature18325
– volume: 18
  start-page: 622
  year: 2020
  ident: 43183_CR5
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41579-020-0407-y
– volume: 196
  start-page: 47
  year: 2012
  ident: 43183_CR67
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201106022
– volume: 13
  start-page: 4167
  year: 2002
  ident: 43183_CR48
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.02-05-0068
– volume: 68
  start-page: 830
  year: 2017
  ident: 43183_CR7
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2017.11.022
– volume: 208
  start-page: 563
  year: 2015
  ident: 43183_CR11
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201406099
– volume: 140
  start-page: 1285
  year: 1998
  ident: 43183_CR52
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.140.6.1285
– volume: 25
  start-page: 1320
  year: 2011
  ident: 43183_CR50
  publication-title: Genes Dev.
  doi: 10.1101/gad.2053211
– volume: 81
  start-page: 4026
  year: 2021
  ident: 43183_CR21
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2021.09.013
– ident: 43183_CR63
  doi: 10.1038/s41586-023-05981-1
– volume: 322
  start-page: 597
  year: 2008
  ident: 43183_CR68
  publication-title: Science
  doi: 10.1126/science.1162790
– volume: 25
  start-page: 1017
  year: 2023
  ident: 43183_CR66
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-023-01167-z
– volume: 8
  year: 2017
  ident: 43183_CR14
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-01180-5
– volume: 09
  start-page: 398
  year: 2018
  ident: 43183_CR27
  publication-title: Front. Genet.
  doi: 10.3389/fgene.2018.00398
– volume: 8
  start-page: 20
  year: 2017
  ident: 43183_CR16
  publication-title: Genes
  doi: 10.3390/genes8010020
– volume: 559
  start-page: 54
  year: 2018
  ident: 43183_CR40
  publication-title: Nature
  doi: 10.1038/s41586-018-0242-8
– volume: 141
  start-page: 123
  year: 2014
  ident: 43183_CR49
  publication-title: Histochem. Cell Biol.
  doi: 10.1007/s00418-013-1151-4
– volume: 380
  start-page: 382
  year: 2023
  ident: 43183_CR12
  publication-title: Science
  doi: 10.1126/science.add7328
– volume: 10
  year: 2019
  ident: 43183_CR36
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-13322-y
– volume: 8
  start-page: eabm0314
  year: 2022
  ident: 43183_CR61
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.abm0314
– volume: 4
  start-page: e07735
  year: 2015
  ident: 43183_CR39
  publication-title: Elife
  doi: 10.7554/eLife.07735
– volume: 36
  start-page: 3212
  year: 2017
  ident: 43183_CR43
  publication-title: EMBO J.
  doi: 10.15252/embj.201796585
– ident: 43183_CR53
– volume: 102
  start-page: 105
  year: 2020
  ident: 43183_CR74
  publication-title: Semin. Cell Dev. Biol.
  doi: 10.1016/j.semcdb.2019.10.012
– volume: 52
  start-page: 566
  year: 2013
  ident: 43183_CR18
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2013.10.035
– ident: 43183_CR51
  doi: 10.1016/j.chembiol.2013.03.019
– volume: 20
  start-page: 347
  year: 2013
  ident: 43183_CR57
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.2501
– volume: 8
  start-page: 15222
  year: 2017
  ident: 43183_CR64
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms15222
– volume: 13
  year: 2022
  ident: 43183_CR45
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-022-31415-z
– volume: 40
  start-page: e106355
  year: 2021
  ident: 43183_CR20
  publication-title: EMBO J.
  doi: 10.15252/embj.2020106355
– volume: 130
  start-page: 525
  year: 2017
  ident: 43183_CR31
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.204487
– volume: 26
  start-page: 151
  year: 2012
  ident: 43183_CR8
  publication-title: Genes Dev.
  doi: 10.1101/gad.178459.111
– volume: 10
  start-page: 425
  year: 2015
  ident: 43183_CR2
  publication-title: Annu. Rev. Pathol.
  doi: 10.1146/annurev-pathol-012414-040424
– volume: 8
  year: 2017
  ident: 43183_CR13
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-01164-5
– volume: 13
  start-page: a040121
  year: 2021
  ident: 43183_CR28
  publication-title: CSH Perspect. Biol.
– volume: 16
  start-page: 207
  year: 2015
  ident: 43183_CR6
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3935
– volume: 19
  start-page: 1389
  year: 2017
  ident: 43183_CR38
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3641
– volume: 159
  start-page: 108
  year: 2014
  ident: 43183_CR70
  publication-title: Cell
  doi: 10.1016/j.cell.2014.08.030
– volume: 601
  start-page: 359
  year: 2018
  ident: 43183_CR76
  publication-title: Methods Enzymol.
  doi: 10.1016/bs.mie.2017.11.033
– ident: 43183_CR26
  doi: 10.1007/s00412-023-00813-7
– volume: 24
  start-page: 353
  year: 2017
  ident: 43183_CR41
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.3387
– volume: 340
  start-page: 864
  year: 2013
  ident: 43183_CR34
  publication-title: Science
  doi: 10.1126/science.1235038
– volume: 290
  start-page: 11209
  year: 2015
  ident: 43183_CR35
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M114.627166
– volume: 82
  start-page: 2298
  year: 2022
  ident: 43183_CR1
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2022.05.004
– volume: 12
  start-page: 773426
  year: 2021
  ident: 43183_CR25
  publication-title: Front. Genet.
  doi: 10.3389/fgene.2021.773426
– volume: 29
  start-page: 462
  year: 2019
  ident: 43183_CR29
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2019.02.010
– volume: 9
  start-page: eade7997
  year: 2023
  ident: 43183_CR62
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.ade7997
– volume: 13
  start-page: 1282
  year: 2011
  ident: 43183_CR30
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2364
– volume: 11
  year: 2020
  ident: 43183_CR65
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-17324-z
– volume: 14
  year: 2023
  ident: 43183_CR47
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-023-39517-y
– reference: 36993227 - bioRxiv. 2023 Mar 25:2023.03.24.534097. doi: 10.1101/2023.03.24.534097.
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Snippet Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replication fork plasticity is achieved in the...
Abstract Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replication fork plasticity is achieved...
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14
14/1
14/19
14/28
631/337/1427/2566
631/337/151/2356
Actin
Actins - genetics
Cell Line, Tumor
Chromatin
Chromosomes
Constraining
Deoxyribonucleic acid
Deregulation
DNA
DNA - genetics
DNA biosynthesis
DNA damage
DNA probes
DNA Replication
Filaments
Genomic instability
Genotoxicity
Humanities and Social Sciences
multidisciplinary
Plastic foam
Plastic properties
Plasticity
Polymerization
Replication
S phase
Science
Science (multidisciplinary)
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Title Nuclear actin polymerization rapidly mediates replication fork remodeling upon stress by limiting PrimPol activity
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