Azathioprine promotes intestinal epithelial cell differentiation into Paneth cells and alleviates ileal Crohn’s disease severity

Paneth cells (PCs), a subset of intestinal epithelial cells (IECs) found at the base of small intestinal crypts, play an essential role in maintaining intestinal homeostasis. Altered PCs function is associated with diverse intestinal pathologies, including ileal Crohn’s disease (CD). CD patients wit...

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Bibliographic Details
Published in:	Scientific reports Vol. 14; no. 1; pp. 12879 - 18
Main Authors:	Ragab, Mohab, Schlichting, Heidi, Hicken, Maren, Mester, Patricia, Hirose, Misa, Almeida, Larissa N., Christiansen, Lea, Ibrahim, Saleh, Tews, Hauke Christian, Divanovic, Senad, Sina, Christian, Derer, Stefanie
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 05.06.2024 Nature Publishing Group Nature Portfolio
Subjects:	631/80/304 692/699/1503/257/1402 Adult Animals Antimicrobial peptides Azathioprine Azathioprine - pharmacology Cell differentiation Cell Differentiation - drug effects Cell Line Cell proliferation Cell Proliferation - drug effects Crohn Disease - drug therapy Crohn Disease - metabolism Crohn Disease - pathology Crohn's disease Epithelial cells Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Epithelium Female Gene expression Glucose Homeostasis Humanities and Social Sciences Humans Ileum - drug effects Ileum - metabolism Ileum - pathology Immunosuppressive agents Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Male Mice Middle Aged Mitochondria multidisciplinary Oral administration Organoids Organoids - drug effects Organoids - metabolism Paneth cells Paneth Cells - drug effects Paneth Cells - metabolism Paneth Cells - pathology Peptides Science Science (multidisciplinary) Severity of Illness Index Small intestine
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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