A bioabsorbable mechanoelectric fiber as electrical stimulation suture

In surgical medicine, suturing is the standard treatment for large incisions, yet traditional sutures are limited in functionality. Electrical stimulation is a non-pharmacological therapy that promotes wound healing. In this context, we designed a passive and biodegradable mechanoelectric suture. Th...

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Bibliographic Details
Published in:Nature communications Vol. 15; no. 1; pp. 8462 - 12
Main Authors: Sun, Zhouquan, Jin, Yuefan, Luo, Jiabei, Li, Linpeng, Ding, Yue, Luo, Yu, Qi, Yan, Li, Yaogang, Zhang, Qinghong, Li, Kerui, Shi, Haibo, Yin, Shankai, Wang, Hongzhi, Wang, Hui, Hou, Chengyi
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 08.10.2024
Nature Publishing Group
Nature Portfolio
Subjects:
639/166/985
639/301/54/990
639/4077/4072/4062
Absorbable Implants
Animals
Biocompatible Materials - chemistry
Biodegradation
Clinical medicine
Electric fields
Electric Stimulation - instrumentation
Electrical stimuli
Glycolic acid
Health risks
Humanities and Social Sciences
Lactic Acid - chemistry
Magnesium
Magnesium - chemistry
Male
Mechanical properties
multidisciplinary
Multilayers
Polycaprolactone
Polyesters - chemistry
Polyglycolic Acid - chemistry
Polylactic Acid-Polyglycolic Acid Copolymer - chemistry
Science
Science (multidisciplinary)
Stimulation
Suture Techniques - instrumentation
Sutures
Wound Healing
Wound infection
ISSN:2041-1723, 2041-1723
Online Access:Get full text
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Summary:In surgical medicine, suturing is the standard treatment for large incisions, yet traditional sutures are limited in functionality. Electrical stimulation is a non-pharmacological therapy that promotes wound healing. In this context, we designed a passive and biodegradable mechanoelectric suture. The suture consists of multi-layer coaxial structure composed of (poly(lactic-co-glycolic acid), polycaprolactone) and magnesium to allow safe degradation. In addition to the excellent mechanical properties, the mechanoelectrical nature of the suture grants the generation of electric fields in response to movement and stretching. This is shown to speed up wound healing by 50% and reduce the risk of infection. This work presents an evolution of the conventional wound closure procedures, using a safe and degradable device ready to be translated into clinical practice. Sutures are ubiquitous in clinical practice. They close wounds and speed up repair. Here the authors show electroactive sutures, made of triboelectric materials. They generate an electric field in response to natural movement that speed up wound healing by more than 50%
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-024-52354-x