The frequency of CD38+ alveolar macrophages correlates with early control of M. tuberculosis in the murine lung

Tuberculosis, caused by Mycobacterium tuberculosis , remains an enduring global health challenge due to the limited efficacy of existing treatments. Although much research has focused on immune failure, the role of host macrophage biology in controlling the disease remains underappreciated. Here we...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 8522 - 19
Main Authors:	Pisu, Davide, Johnston, Luana, Mattila, Joshua T., Russell, David G.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 02.10.2024 Nature Publishing Group Nature Portfolio
Subjects:	38 38/90 38/91 45 631/250/2504/342/1927 631/250/255/1318 631/250/255/1856 631/326/1320 64 64/60 ADP-ribosyl Cyclase 1 - genetics ADP-ribosyl Cyclase 1 - metabolism Alveoli Animal models Animals Bacillus Calmette-Guerin vaccine BCG BCG Vaccine - immunology CD38 antigen Chromatin Disease control Disease Models, Animal Epigenetics Female Gene sequencing Global health Humanities and Social Sciences Immune system Immunization Infections Lung - immunology Lung - microbiology Lung - pathology Macrophages Macrophages, Alveolar - immunology Macrophages, Alveolar - metabolism Macrophages, Alveolar - microbiology Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Monocytes multidisciplinary Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Public health Science Science (multidisciplinary) Single-Cell Analysis Tuberculosis Tuberculosis - immunology Tuberculosis - microbiology Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - microbiology Tuberculosis, Pulmonary - pathology Vaccines
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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