Exposure to a mixture of non-persistent environmental chemicals and neonatal thyroid function in a cohort with improved exposure assessment

In vitro and toxicological studies have shown that non-persistent environmental chemicals can perturb thyroid hormone homeostasis. Epidemiological studies with improved exposure assessment (i.e., repeated urine samples) are needed to evaluate effects of these compounds, individually or as a mixture,...

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Vydáno v:	Environment international Ročník 173; s. 107840
Hlavní autoři:	Coiffier, Ophélie, Nakiwala, Dorothy, Rolland, Matthieu, Malatesta, Andres, Lyon-Caen, Sarah, Chovelon, Benoît, Faure, Patrice, Sophie Gauchez, Anne, Guergour, Dorra, Sakhi, Amrit K., Sabaredzovic, Azemira, Thomsen, Cathrine, Pin, Isabelle, Slama, Rémy, Corne, Christelle, Philippat, Claire
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier Ltd 01.03.2023 Elsevier
Témata:	Bayes Theorem Bayesian theory benzophenones Bisphenols blood serum children DINCH environment Environmental Exposure - adverse effects Environmental Pollutants - urine Environmental Sciences exposure assessment Female Heel-prick blood spot homeostasis Hormones Humans Infant, Newborn iodine Male maternal exposure metabolites Mixture Parabens Parabens - analysis Phthalates Phthalic Acids - toxicity Phthalic Acids - urine Pregnancy Prenatal Exposure Delayed Effects regression analysis selenium thyroid function Thyroid Gland Thyroid Hormones Thyrotropin thyroxine triclosan Triclosan - toxicity urine MEHP oxo-MINCH DiNP MMCHP Heel-prick blood spot Mixture MBzP oxo-MiNP Bisphenols ΣDiNP DEHP OH-MPHP Thyroid hormones ΣDINCH T3 WHO LOD T4 MEOHP MEHHP TSH MnBP Oh-MINCH Phthalates DINCH DEP MiBP Parabens LOQ Oh-MiNP BKMR ΣDEHP MECPP MEP cx-MiNP
ISSN:	0160-4120, 1873-6750, 1873-6750
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Popis
Shrnutí:	In vitro and toxicological studies have shown that non-persistent environmental chemicals can perturb thyroid hormone homeostasis. Epidemiological studies with improved exposure assessment (i.e., repeated urine samples) are needed to evaluate effects of these compounds, individually or as a mixture, in humans. We studied the associations between prenatal exposure to non-persistent environmental chemicals and neonatal thyroid hormones. The study population consisted of 442 mother–child pairs from the French SEPAGES mother–child cohort recruited between July 2014 and July 2017. For each participant, four parabens, five bisphenols, triclosan, triclocarban, benzophenone-3 as well as metabolites of phthalates and of di(isononyl)cyclohexane-1,2-dicarboxylate were assessed in two pools of repeated urine samples (median: 21 spot urines per pool), collected in the 2nd and 3rd trimesters of pregnancy, respectively. Thyroid stimulating hormone (TSH) and total thyroxine (T4) levels were determined in newborns from a heel-prick blood spot. Maternal iodine and selenium were assessed in urine and serum, respectively. Adjusted linear regression (uni-pollutant model) and Bayesian Kernel Machine Regression (BKMR, mixture model) were applied to study overall and sex-stratified associations between chemicals and hormone concentrations. Interaction with child sex was detected for several compounds. Triclosan, three parabens, and one phthalate metabolite (OH-MPHP) were negatively associated with T4 among girls in the uni-pollutant model. BKMR also suggested a negative association between the mixture and T4 in girls, whereas in boys the association was positive. The mixture was not linked to TSH levels, and for this hormone the uni-pollutant model revealed associations with only a few compounds. Our study, based on repeated urine samples to assess exposure, showed that prenatal exposure to some phenols and phthalates disturb thyroid hormone homeostasis at birth. Furthermore, both uni-pollutant and mixture models, suggested effect modification by child sex, while, to date underlying mechanisms for such sex-differences are not well understood.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0160-4120 1873-6750 1873-6750
DOI:	10.1016/j.envint.2023.107840