COVID-19 immune signatures in Uganda persist in HIV co-infection and diverge by pandemic phase

Little is known about the pathobiology of SARS-CoV-2 infection in sub-Saharan Africa, where severe COVID-19 fatality rates are among the highest in the world and the immunological landscape is unique. In a prospective cohort study of 306 adults encompassing the entire clinical spectrum of SARS-CoV-2...

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Veröffentlicht in:	Nature communications Jg. 15; H. 1; S. 1475 - 18
Hauptverfasser:	Cummings, Matthew J., Bakamutumaho, Barnabas, Lutwama, Julius J., Owor, Nicholas, Che, Xiaoyu, Astorkia, Maider, Postler, Thomas S., Kayiwa, John, Kiconco, Jocelyn, Muwanga, Moses, Nsereko, Christopher, Rwamutwe, Emmanuel, Nayiga, Irene, Kyebambe, Stephen, Haumba, Mercy, Bosa, Henry Kyobe, Ocom, Felix, Watyaba, Benjamin, Kikaire, Bernard, Tomoiaga, Alin S., Kisaka, Stevens, Kiwanuka, Noah, Lipkin, W. Ian, O’Donnell, Max R.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 17.02.2024 Nature Publishing Group Nature Portfolio
Schlagworte:	631/250/2502 631/250/2520 631/250/254 631/250/255/2514 692/420/254 Adult Adults CD8 antigen Cell activation Coinfection - epidemiology COVID-19 Fibrosis Growth factors HIV HIV Infections - complications HIV Infections - epidemiology Human immunodeficiency virus Humanities and Social Sciences Humans Immune response Immune system Immunology Immunopathology Immunotherapy Infections Inflammasomes Inflammation Lung diseases Lymphocytes Lymphocytes T Lymphopenia Lymphotoxin multidisciplinary Pandemics Peripheral blood Platelet-derived growth factor Prospective Studies Protein biosynthesis Protein synthesis Proteins Proteomes Respiratory tract infection SARS-CoV-2 Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Transcriptomes Tumor necrosis factor-β Uganda - epidemiology Viral diseases Uganda Africa
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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