Smoking and salivary microbiota: a cross-sectional analysis of an Italian alpine population

The oral microbiota plays an important role in the exogenous nitrate reduction pathway and is associated with heart and periodontal disease and cigarette smoking. We describe smoking-related changes in oral microbiota composition and resulting potential metabolic pathway changes that may explain smo...

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Vydáno v:Scientific reports Ročník 13; číslo 1; s. 18904 - 12
Hlavní autoři: Antonello, Giacomo, Blostein, Freida, Bhaumik, Deesha, Davis, Elyse, Gögele, Martin, Melotti, Roberto, Pramstaller, Peter, Pattaro, Cristian, Segata, Nicola, Foxman, Betsy, Fuchsberger, Christian
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 02.11.2023
Nature Publishing Group
Nature Portfolio
Témata:
631/326
692/499
692/53
692/700
Cigarette Smoking
Cigarettes
Cross-Sectional Studies
Health risks
Heart diseases
Humanities and Social Sciences
Humans
Metabolic pathways
Metabolism
Microbiota
Microbiota - genetics
Microorganisms
multidisciplinary
Nitrate reduction
Nitrates
Periodontal diseases
Relative abundance
RNA, Ribosomal, 16S - genetics
rRNA 16S
Science
Science (multidisciplinary)
Smokers
Smoking
ISSN:2045-2322, 2045-2322
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Shrnutí:The oral microbiota plays an important role in the exogenous nitrate reduction pathway and is associated with heart and periodontal disease and cigarette smoking. We describe smoking-related changes in oral microbiota composition and resulting potential metabolic pathway changes that may explain smoking-related changes in disease risk. We analyzed health information and salivary microbiota composition among 1601 Cooperative Health Research in South Tyrol participants collected 2017–2018. Salivary microbiota taxa were assigned from amplicon sequences of the 16S-V4 rRNA and used to describe microbiota composition and predict metabolic pathways. Aerobic taxa relative abundance decreased with daily smoking intensity and increased with years since cessation, as did inferred nitrate reduction. Former smokers tended to be more similar to Never smokers than to Current smokers, especially those who had quit for longer than 5 years. Cigarette smoking has a consistent, generalizable association on oral microbiota composition and predicted metabolic pathways, some of which associate in a dose-dependent fashion. Smokers who quit for longer than 5 years tend to have salivary microbiota profiles comparable to never smokers.
Bibliografie:ObjectType-Article-1
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-42474-7