Epigenetic footprints: Investigating placental DNA methylation in the context of prenatal exposure to phenols and phthalates

•28 differentially methylated regions (DMRs), 40 for females and 42 for males.•Sex-specific effects, with few common probes and DMRs between sexes.•Most DMRs associated with parabens, DEHP, and DiNP metabolites.•DMRs encompassed 9 imprinted genes.•Enrichment in adiposity, lipid and glucose metabolis...

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Vydané v:	Environment international Ročník 189; s. 108763
Hlavní autori:	Jedynak, Paulina, Siroux, Valérie, Broséus, Lucile, Tost, Jörg, Busato, Florence, Gabet, Stephan, Thomsen, Cathrine, Sakhi, Amrit K., Sabaredzovic, Azemira, Lyon-Caen, Sarah, Bayat, Sam, Slama, Rémy, Philippat, Claire, Lepeule, Johanna
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Netherlands Elsevier Ltd 01.07.2024 Elsevier
Predmet:	adiposity Benzophenone biomarkers Bisphenol DNA methylation Endocrine disruptors environment Epigenetics epigenome exposure assessment genes glucose Life Sciences lipids maternal exposure metabolism metabolites Phthalates Placenta plasticizers pregnancy Santé publique et épidémiologie urine Endocrine disruptors EWAS MEHP OH-MINCH EDC oxo-MINCH DiNP MMCHP Benzophenone MBzP QC MCOP oxo-MiNP SLK FDR ΣDiNP DEHP nRBC OH-MPHP ΣDINCH Bisphenol BMI LOD MEOHP MEHHP DMR EDEN eQTM IQR MnBP Phthalates DINCH LMP MiBP LOQ MCPP Placenta ΣDEHP OH-MiNP MECPP Epigenetics MEP cx-MiNP MCNP phtalates epigenetics
ISSN:	0160-4120, 1873-6750, 1873-6750
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