SPRING licenses S1P-mediated cleavage of SREBP2 by displacing an inhibitory pro-domain

Site-one protease (S1P) conducts the first of two cleavage events in the Golgi to activate Sterol regulatory element binding proteins (SREBPs) and upregulate lipogenic transcription. S1P is also required for a wide array of additional signaling pathways. A zymogen serine protease, S1P matures throug...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 5732 - 17
Main Authors:	Hendrix, Sebastian, Dartigue, Vincent, Hall, Hailee, Bawaria, Shrankhla, Kingma, Jenina, Bajaj, Bilkish, Zelcer, Noam, Kober, Daniel L.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 09.07.2024 Nature Publishing Group Nature Portfolio
Subjects:	101/28 13/106 13/109 631/45/287/1197 631/45/468 631/45/535/1258/1259 82/29 82/83 Animals Biochemistry Cholesterol Cholesterol - metabolism Cleavage Cryoelectron Microscopy Endoplasmic reticulum Endoplasmic Reticulum - metabolism Enzymes Fatty acids Golgi apparatus Golgi Apparatus - metabolism HEK293 Cells Homeostasis Humanities and Social Sciences Humans Licenses Metabolism multidisciplinary Mutation Peptides Proenzymes Proprotein Convertases - genetics Proprotein Convertases - metabolism Protease Protein Domains Regulatory sequences Science Science (multidisciplinary) Serine Endopeptidases - chemistry Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Serine proteinase Signal Transduction Sterol Regulatory Element Binding Protein 2 - genetics Sterol Regulatory Element Binding Protein 2 - metabolism Sterol regulatory element-binding protein Sterols Substrates Transcription factors
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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