PTEN Mutations as a Cause of Constitutive Insulin Sensitivity and Obesity

Evidence suggests that protection against cancer confers a risk of type 2 diabetes and vice versa. This study shows that persons susceptible to cancer owing to a constitutive mutation in the tumor-suppressor gene PTEN also have heightened sensitivity to insulin and are obese. Epidemiologic evidence...

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Bibliographic Details
Published in:The New England journal of medicine Vol. 367; no. 11; pp. 1002 - 1011
Main Authors: Pal, Aparna, Barber, Thomas M, Van de Bunt, Martijn, Rudge, Simon A, Zhang, Qifeng, Lachlan, Katherine L, Cooper, Nicola S, Linden, Helen, Levy, Jonathan C, Wakelam, Michael J.O, Walker, Lisa, Karpe, Fredrik, Gloyn, Anna L
Format: Journal Article
Language:English
Published: Waltham, MA Massachusetts Medical Society 13.09.2012
Subjects:
1-Phosphatidylinositol 3-kinase
Absorptiometry
Adiponectin - blood
Adipose Tissue
Adult
Aged
AKT protein
Anthropomorphism
Beta cells
Biological and medical sciences
Biomedical research
Biopsy
Body composition
Body mass
Body Mass Index
Cancer
Cell growth
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - genetics
Epidemiology
Female
General aspects
Glucose
Glucose Tolerance Test
Haploinsufficiency
Humans
Insulin
Insulin resistance
Insulin Resistance - genetics
Laboratories
Leptin - blood
Male
Medical sciences
Metabolic diseases
Metabolism
Middle Aged
Mutation
Neoplasms - complications
Neoplasms - genetics
Obesity
Obesity - complications
Obesity - genetics
Phosphatase
Phosphorylation
Population studies
PTEN Phosphohydrolase - genetics
PTEN protein
Skinfold thickness
Tensin
Thyroid gland
United Kingdom > UK
Medicine
Obesity
Pancreatic hormone
Nutrition disorder
Cause
Genetics
PTEN Gene
Mutation
Insulin
Nutritional status
Tumor suppressor gene
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Summary:Evidence suggests that protection against cancer confers a risk of type 2 diabetes and vice versa. This study shows that persons susceptible to cancer owing to a constitutive mutation in the tumor-suppressor gene PTEN also have heightened sensitivity to insulin and are obese. Epidemiologic evidence for a link among type 2 diabetes, obesity, and cancer has increased interest in the idea that some antidiabetes therapies may increase the risk of susceptibility to cancer, whereas others appear to offer protection. 1 Such a link is also supported by the discovery of several susceptibility loci for type 2 diabetes and their unexpected proximity to genes implicated in cell-cycle regulation. 2 The discovery of common genetic variants that influence both the risk of cancer and the risk of type 2 diabetes, in opposite directions, suggests that the two conditions may result from defects in the same pathway. 3 – . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1113966