PTEN Mutations as a Cause of Constitutive Insulin Sensitivity and Obesity

Evidence suggests that protection against cancer confers a risk of type 2 diabetes and vice versa. This study shows that persons susceptible to cancer owing to a constitutive mutation in the tumor-suppressor gene PTEN also have heightened sensitivity to insulin and are obese. Epidemiologic evidence...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	The New England journal of medicine Ročník 367; číslo 11; s. 1002 - 1011
Hlavní autoři:	Pal, Aparna, Barber, Thomas M, Van de Bunt, Martijn, Rudge, Simon A, Zhang, Qifeng, Lachlan, Katherine L, Cooper, Nicola S, Linden, Helen, Levy, Jonathan C, Wakelam, Michael J.O, Walker, Lisa, Karpe, Fredrik, Gloyn, Anna L
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Waltham, MA Massachusetts Medical Society 13.09.2012
Témata:	1-Phosphatidylinositol 3-kinase Absorptiometry Adiponectin - blood Adipose Tissue Adult Aged AKT protein Anthropomorphism Beta cells Biological and medical sciences Biomedical research Biopsy Body composition Body mass Body Mass Index Cancer Cell growth Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - genetics Epidemiology Female General aspects Glucose Glucose Tolerance Test Haploinsufficiency Humans Insulin Insulin resistance Insulin Resistance - genetics Laboratories Leptin - blood Male Medical sciences Metabolic diseases Metabolism Middle Aged Mutation Neoplasms - complications Neoplasms - genetics Obesity Obesity - complications Obesity - genetics Phosphatase Phosphorylation Population studies PTEN Phosphohydrolase - genetics PTEN protein Skinfold thickness Tensin Thyroid gland United Kingdom > UK Medicine Obesity Pancreatic hormone Nutrition disorder Cause Genetics PTEN Gene Mutation Insulin Nutritional status Tumor suppressor gene
ISSN:	0028-4793, 1533-4406, 1533-4406
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!