Coenzyme A binding sites induce proximal acylation across protein families

Lysine Nɛ-acylations, such as acetylation or succinylation, are post-translational modifications that regulate protein function. In mitochondria, lysine acylation is predominantly non-enzymatic, and only a specific subset of the proteome is acylated. Coenzyme A (CoA) can act as an acyl group carrier...

Full description

Saved in:

Bibliographic Details
Published in:	Scientific reports Vol. 13; no. 1; pp. 5029 - 14
Main Authors:	Carrico, Chris, Cruz, Andrew, Walter, Marius, Meyer, Jesse, Wehrfritz, Cameron, Shah, Samah, Wei, Lei, Schilling, Birgit, Verdin, Eric
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 28.03.2023 Nature Publishing Group Nature Portfolio
Subjects:	631/114 631/114/2410 631/114/663 631/45 631/45/173 631/45/475 631/45/612 Acetylation Acyl Coenzyme A - metabolism Acylation Binding Sites Coenzyme A Computer applications Enoyl-CoA hydratase Humanities and Social Sciences Lysine Lysine - metabolism Mass spectrometry Mass spectroscopy Mitochondria multidisciplinary Post-translation Protein families Protein Processing, Post-Translational Proteins Proteomes Science Science (multidisciplinary) Succinyl-CoA
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!