Coenzyme A binding sites induce proximal acylation across protein families

Lysine Nɛ-acylations, such as acetylation or succinylation, are post-translational modifications that regulate protein function. In mitochondria, lysine acylation is predominantly non-enzymatic, and only a specific subset of the proteome is acylated. Coenzyme A (CoA) can act as an acyl group carrier...

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Veröffentlicht in:	Scientific reports Jg. 13; H. 1; S. 5029 - 14
Hauptverfasser:	Carrico, Chris, Cruz, Andrew, Walter, Marius, Meyer, Jesse, Wehrfritz, Cameron, Shah, Samah, Wei, Lei, Schilling, Birgit, Verdin, Eric
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 28.03.2023 Nature Publishing Group Nature Portfolio
Schlagworte:	631/114 631/114/2410 631/114/663 631/45 631/45/173 631/45/475 631/45/612 Acetylation Acyl Coenzyme A - metabolism Acylation Binding Sites Coenzyme A Computer applications Enoyl-CoA hydratase Humanities and Social Sciences Lysine Lysine - metabolism Mass spectrometry Mass spectroscopy Mitochondria multidisciplinary Post-translation Protein families Protein Processing, Post-Translational Proteins Proteomes Science Science (multidisciplinary) Succinyl-CoA
ISSN:	2045-2322, 2045-2322
Online-Zugang:	Volltext
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