Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer’s pathology

Dysfunction in fast-spiking parvalbumin interneurons (PV-INs) may represent an early pathophysiological perturbation in Alzheimer’s Disease (AD). Defining early proteomic alterations in PV-INs can provide key biological and translationally-relevant insights. We used cell-type-specific in-vivo biotin...

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Vydáno v:	Nature communications Ročník 15; číslo 1; s. 2823 - 26
Hlavní autoři:	Kumar, Prateek, Goettemoeller, Annie M., Espinosa-Garcia, Claudia, Tobin, Brendan R., Tfaily, Ali, Nelson, Ruth S., Natu, Aditya, Dammer, Eric B., Santiago, Juliet V., Malepati, Sneha, Cheng, Lihong, Xiao, Hailian, Duong, Duc D., Seyfried, Nicholas T., Wood, Levi B., Rowan, Matthew J. M., Rangaraju, Srikant
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 01.04.2024 Nature Publishing Group Nature Portfolio
Témata:	13/1 13/44 13/95 14/63 631/378/1689/1283 631/45/475 82/1 82/51 82/58 9/74 Alzheimer Disease - metabolism Alzheimer's disease Amyloid Animals Biotinylation Cognitive ability Cytoskeleton Humanities and Social Sciences Humans Interneurons Interneurons - metabolism Mass spectrometry Mass spectroscopy Metabolism Mice Mice, Transgenic Mitochondria multidisciplinary Neurodegenerative diseases Neurotransmission Parvalbumin Parvalbumins - metabolism Pathogenesis Pathology Proteins Proteome - metabolism Proteomes Proteomics Resilience Science Science (multidisciplinary) TOR protein Translation β-Amyloid
ISSN:	2041-1723, 2041-1723
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