PFAS exposure during pregnancy: Implications for placental health and functioning
[Display omitted] •First study about the effects of PFAS on human placental histological parameters.•PFTrDA, PFHxPA, PFHpA, and 6:2 diPAP associated with fetal − maternal exchanges.•Women in the moderate/high exposure cluster had reduced placental weight. Animal studies have linked prenatal poly- an...
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| Vydáno v: | Environment international Ročník 197; s. 109308 |
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| Hlavní autoři: | , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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Netherlands
Elsevier Ltd
01.03.2025
Elsevier |
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| ISSN: | 0160-4120, 1873-6750, 1873-6750 |
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| Abstract | [Display omitted]
•First study about the effects of PFAS on human placental histological parameters.•PFTrDA, PFHxPA, PFHpA, and 6:2 diPAP associated with fetal − maternal exchanges.•Women in the moderate/high exposure cluster had reduced placental weight.
Animal studies have linked prenatal poly- and perfluoroalkyl substances (PFAS) exposures with impaired placental structure and function. In humans, only few studies have investigated such associations.
We studied whether PFAS, individually and as a mixture, affected placental function.
In 367 pregnant women, we quantified 13 PFAS in serum collected at 19.3 gestational weeks (median). Placental weight was recorded at delivery. Histological examination of placental tissues allowed estimation of vascular perfusion (percentage of villi with syncytial knots, capillary density, intervillous space) and placental aging (fibrin deposition, calcification). Associations between PFAS and each of these parameters were assessed using adjusted linear, logistic regressions and mixture modeling through cluster analysis and Bayesian kernel machine regression (BKMR).
PFHxPA quantification (yes versus no) was associated with an increase in the percentages of villi with syncytial knots (β = 6.0% [95% CI: 1.1; 11]) and reduced intervillous spaces (β = 4.7% [95% CI: 0.1; 9.3]). A similar pattern was observed with PFHpA. Isolated associations were observed between PFTrDA and percentages of villi with syncytial knots (β = 8.6% [95% CI: 2.2; 15]) and 6:2diPAP and capillary density (β = −17% [95% CI: −30; −4.6]). Cluster analysis suggested that women in the moderate-to-higher PFAS exposure group had on average lower placental weight (β= −30 g [95% CI: −56; −4.3]), compared to those in the lower exposure group.
Pregnancy PFAS levels were associated with placental parameters of fetal-maternal exchange, highlighting their broad physiological impacts. |
|---|---|
| AbstractList | Animal studies have linked prenatal poly- and perfluoroalkyl substances (PFAS) exposures with impaired placental structure and function. In humans, only few studies have investigated such associations. We studied whether PFAS, individually and as a mixture, affected placental function. In 367 pregnant women, we quantified 13 PFAS in serum collected at 19.3 gestational weeks (median). Placental weight was recorded at delivery. Histological examination of placental tissues allowed estimation of vascular perfusion (percentage of villi with syncytial knots, capillary density, intervillous space) and placental aging (fibrin deposition, calcification). Associations between PFAS and each of these parameters were assessed using adjusted linear, logistic regressions and mixture modeling through cluster analysis and Bayesian kernel machine regression (BKMR). PFHxPA quantification (yes versus no) was associated with an increase in the percentages of villi with syncytial knots (β = 6.0% [95% CI: 1.1; 11]) and reduced intervillous spaces (β = 4.7% [95% CI: 0.1; 9.3]). A similar pattern was observed with PFHpA. Isolated associations were observed between PFTrDA and percentages of villi with syncytial knots (β = 8.6% [95% CI: 2.2; 15]) and 6:2diPAP and capillary density (β = −17% [95% CI: −30; −4.6]). Cluster analysis suggested that women in the moderate-to-higher PFAS exposure group had on average lower placental weight (β= −30 g [95% CI: −56; −4.3]), compared to those in the lower exposure group. Pregnancy PFAS levels were associated with placental parameters of fetal-maternal exchange, highlighting their broad physiological impacts. [Display omitted] •First study about the effects of PFAS on human placental histological parameters.•PFTrDA, PFHxPA, PFHpA, and 6:2 diPAP associated with fetal − maternal exchanges.•Women in the moderate/high exposure cluster had reduced placental weight. Animal studies have linked prenatal poly- and perfluoroalkyl substances (PFAS) exposures with impaired placental structure and function. In humans, only few studies have investigated such associations. We studied whether PFAS, individually and as a mixture, affected placental function. In 367 pregnant women, we quantified 13 PFAS in serum collected at 19.3 gestational weeks (median). Placental weight was recorded at delivery. Histological examination of placental tissues allowed estimation of vascular perfusion (percentage of villi with syncytial knots, capillary density, intervillous space) and placental aging (fibrin deposition, calcification). Associations between PFAS and each of these parameters were assessed using adjusted linear, logistic regressions and mixture modeling through cluster analysis and Bayesian kernel machine regression (BKMR). PFHxPA quantification (yes versus no) was associated with an increase in the percentages of villi with syncytial knots (β = 6.0% [95% CI: 1.1; 11]) and reduced intervillous spaces (β = 4.7% [95% CI: 0.1; 9.3]). A similar pattern was observed with PFHpA. Isolated associations were observed between PFTrDA and percentages of villi with syncytial knots (β = 8.6% [95% CI: 2.2; 15]) and 6:2diPAP and capillary density (β = −17% [95% CI: −30; −4.6]). Cluster analysis suggested that women in the moderate-to-higher PFAS exposure group had on average lower placental weight (β= −30 g [95% CI: −56; −4.3]), compared to those in the lower exposure group. Pregnancy PFAS levels were associated with placental parameters of fetal-maternal exchange, highlighting their broad physiological impacts. Animal studies have linked prenatal poly- and perfluoroalkyl substances (PFAS) exposures with impaired placental structure and function. In humans, only few studies have investigated such associations.BACKGROUNDAnimal studies have linked prenatal poly- and perfluoroalkyl substances (PFAS) exposures with impaired placental structure and function. In humans, only few studies have investigated such associations.We studied whether PFAS, individually and as a mixture, affected placental function.OBJECTIVEWe studied whether PFAS, individually and as a mixture, affected placental function.In 367 pregnant women, we quantified 13 PFAS in serum collected at 19.3 gestational weeks (median). Placental weight was recorded at delivery. Histological examination of placental tissues allowed estimation of vascular perfusion (percentage of villi with syncytial knots, capillary density, intervillous space) and placental aging (fibrin deposition, calcification). Associations between PFAS and each of these parameters were assessed using adjusted linear, logistic regressions and mixture modeling through cluster analysis and Bayesian kernel machine regression (BKMR).METHODSIn 367 pregnant women, we quantified 13 PFAS in serum collected at 19.3 gestational weeks (median). Placental weight was recorded at delivery. Histological examination of placental tissues allowed estimation of vascular perfusion (percentage of villi with syncytial knots, capillary density, intervillous space) and placental aging (fibrin deposition, calcification). Associations between PFAS and each of these parameters were assessed using adjusted linear, logistic regressions and mixture modeling through cluster analysis and Bayesian kernel machine regression (BKMR).PFHxPA quantification (yes versus no) was associated with an increase in the percentages of villi with syncytial knots (β = 6.0% [95% CI: 1.1; 11]) and reduced intervillous spaces (β = 4.7% [95% CI: 0.1; 9.3]). A similar pattern was observed with PFHpA. Isolated associations were observed between PFTrDA and percentages of villi with syncytial knots (β = 8.6% [95% CI: 2.2; 15]) and 6:2diPAP and capillary density (β = -17% [95% CI: -30; -4.6]). Cluster analysis suggested that women in the moderate-to-higher PFAS exposure group had on average lower placental weight (β= -30 g [95% CI: -56; -4.3]), compared to those in the lower exposure group.RESULTSPFHxPA quantification (yes versus no) was associated with an increase in the percentages of villi with syncytial knots (β = 6.0% [95% CI: 1.1; 11]) and reduced intervillous spaces (β = 4.7% [95% CI: 0.1; 9.3]). A similar pattern was observed with PFHpA. Isolated associations were observed between PFTrDA and percentages of villi with syncytial knots (β = 8.6% [95% CI: 2.2; 15]) and 6:2diPAP and capillary density (β = -17% [95% CI: -30; -4.6]). Cluster analysis suggested that women in the moderate-to-higher PFAS exposure group had on average lower placental weight (β= -30 g [95% CI: -56; -4.3]), compared to those in the lower exposure group.Pregnancy PFAS levels were associated with placental parameters of fetal-maternal exchange, highlighting their broad physiological impacts.CONCLUSIONSPregnancy PFAS levels were associated with placental parameters of fetal-maternal exchange, highlighting their broad physiological impacts. Animal studies have linked prenatal poly- and perfluoroalkyl substances (PFAS) exposures with impaired placental structure and function. In humans, only few studies have investigated such associations. We studied whether PFAS, individually and as a mixture, affected placental function. In 367 pregnant women, we quantified 13 PFAS in serum collected at 19.3 gestational weeks (median). Placental weight was recorded at delivery. Histological examination of placental tissues allowed estimation of vascular perfusion (percentage of villi with syncytial knots, capillary density, intervillous space) and placental aging (fibrin deposition, calcification). Associations between PFAS and each of these parameters were assessed using adjusted linear, logistic regressions and mixture modeling through cluster analysis and Bayesian kernel machine regression (BKMR). PFHxPA quantification (yes versus no) was associated with an increase in the percentages of villi with syncytial knots (β = 6.0% [95% CI: 1.1; 11]) and reduced intervillous spaces (β = 4.7% [95% CI: 0.1; 9.3]). A similar pattern was observed with PFHpA. Isolated associations were observed between PFTrDA and percentages of villi with syncytial knots (β = 8.6% [95% CI: 2.2; 15]) and 6:2diPAP and capillary density (β = -17% [95% CI: -30; -4.6]). Cluster analysis suggested that women in the moderate-to-higher PFAS exposure group had on average lower placental weight (β= -30 g [95% CI: -56; -4.3]), compared to those in the lower exposure group. Pregnancy PFAS levels were associated with placental parameters of fetal-maternal exchange, highlighting their broad physiological impacts. Background: Animal studies have linked prenatal poly-and perfluoroalkyl substances (PFAS) exposures with impaired placental structure and function. In humans, only few studies have investigated such associations. Objective: We studied whether PFAS, individually and as a mixture, affected placental function. Methods: In 367 pregnant women, we quantified 13 PFAS in serum collected at 19.3 gestational weeks (median). Placental weight was recorded at delivery. Histological examination of placental tissues allowed estimation of vascular perfusion (percentage of villi with syncytial knots, capillary density, intervillous space) and placental aging (fibrin deposition, calcification). Associations between PFAS and each of these parameters were assessed using adjusted linear, logistic regressions and mixture modeling through cluster analysis and Bayesian kernel machine regression (BKMR). Results: PFHxPA quantification (yes versus no) was associated with an increase in the percentages of villi with syncytial knots (β = 6.0% [95% CI: 1.1; 11]) and reduced intervillous spaces (β = 4.7% [95% CI: 0.1; 9.3]). A similar pattern was observed with PFHpA. Isolated associations were observed between PFTrDA and percentages of villi with syncytial knots (β = 8.6% [95% CI: 2.2; 15]) and 6:2diPAP and capillary density (β = -17% [95% CI: -30; -4.6]). Cluster analysis suggested that women in the moderate-to-higher PFAS exposure group had on average lower placental weight (β= -30 g [95% CI: -56; -4.3]), compared to those in the lower exposure group. Conclusions: Pregnancy PFAS levels were associated with placental parameters of fetal-maternal exchange, highlighting their broad physiological impacts. Background: Animal studies have linked prenatal poly- and perfluoroalkyl substances (PFAS) exposures with impaired placental structure and function. In humans, only few studies have investigated such associations. Objective: We studied whether PFAS, individually and as a mixture, affected placental function. Methods: In 367 pregnant women, we quantified 13 PFAS in serum collected at 19.3 gestational weeks (median). Placental weight was recorded at delivery. Histological examination of placental tissues allowed estimation of vascular perfusion (percentage of villi with syncytial knots, capillary density, intervillous space) and placental aging (fibrin deposition, calcification). Associations between PFAS and each of these parameters were assessed using adjusted linear, logistic regressions and mixture modeling through cluster analysis and Bayesian kernel machine regression (BKMR). Results: PFHxPA quantification (yes versus no) was associated with an increase in the percentages of villi with syncytial knots (β = 6.0% [95% CI: 1.1; 11]) and reduced intervillous spaces (β = 4.7% [95% CI: 0.1; 9.3]). A similar pattern was observed with PFHpA. Isolated associations were observed between PFTrDA and percentages of villi with syncytial knots (β = 8.6% [95% CI: 2.2; 15]) and 6:2diPAP and capillary density (β = −17% [95% CI: −30; −4.6]). Cluster analysis suggested that women in the moderate-to-higher PFAS exposure group had on average lower placental weight (β= −30 g [95% CI: −56; −4.3]), compared to those in the lower exposure group. Conclusions: Pregnancy PFAS levels were associated with placental parameters of fetal-maternal exchange, highlighting their broad physiological impacts. |
| ArticleNumber | 109308 |
| Author | Khan, Sadia Ouidir, Marion Jovanovic, Nicolas Alfaidy, Nadia Philippat, Claire Bayat, Sam Hoffmann, Pascale Siroux, Valérie Couturier-Tarrade, A. Lemaitre, Nicolas Småstuen Haug, Line Desseux, Morgane Valmary-Degano, Séverine Slama, Rémy Lyon-Caen, Sarah Thomsen, Cathrine |
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| CitedBy_id | crossref_primary_10_1016_j_foodcont_2025_111611 crossref_primary_10_1016_j_envint_2025_109729 crossref_primary_10_1016_j_toxlet_2025_07_333 crossref_primary_10_1016_j_envres_2025_121846 crossref_primary_10_3390_ijerph22071116 |
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| Keywords | Endocrine disruptors DOHaD FPR PFNA PFAS Mixture 6:2 diPAP Angiogenesis Per- and Polyfluoroalkyl Substances PFDA PFHxPA PFTrDA Fetal maternal exchanges PFR PFPeA HPLC LOD PFDoDA PFBS OR PFHxS CI 6:2Cl-PFESA MS Histology PFUnDA PFHpA Placental Vascularization PFOA LOQ GW BKMR br-PFHxS PFHpS PFOS |
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| PublicationDate | 2025-03-01 |
| PublicationDateYYYYMMDD | 2025-03-01 |
| PublicationDate_xml | – month: 03 year: 2025 text: 2025-03-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Environment international |
| PublicationTitleAlternate | Environ Int |
| PublicationYear | 2025 |
| Publisher | Elsevier Ltd Elsevier |
| Publisher_xml | – name: Elsevier Ltd – name: Elsevier |
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•First study about the effects of PFAS on human placental histological parameters.•PFTrDA, PFHxPA, PFHpA, and 6:2 diPAP associated with fetal... Animal studies have linked prenatal poly- and perfluoroalkyl substances (PFAS) exposures with impaired placental structure and function. In humans, only few... Background: Animal studies have linked prenatal poly-and perfluoroalkyl substances (PFAS) exposures with impaired placental structure and function. In humans,... Background: Animal studies have linked prenatal poly- and perfluoroalkyl substances (PFAS) exposures with impaired placental structure and function. In humans,... |
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| SubjectTerms | Adult Angiogenesis animals Bayesian theory blood serum calcification cluster analysis Endocrine disruptors environment Environmental Pollutants - blood Environmental Pollutants - toxicity Female Fetal maternal exchanges fibrin Fluorocarbons - blood Fluorocarbons - toxicity Histology Humans Life Sciences Maternal Exposure - statistics & numerical data Mixture Per- and Polyfluoroalkyl Substances perfluorotridecanoic acid Placenta - drug effects Placenta - physiology Placental Vascularization Pregnancy Young Adult |
| Title | PFAS exposure during pregnancy: Implications for placental health and functioning |
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