PFAS exposure during pregnancy: Implications for placental health and functioning

[Display omitted] •First study about the effects of PFAS on human placental histological parameters.•PFTrDA, PFHxPA, PFHpA, and 6:2 diPAP associated with fetal − maternal exchanges.•Women in the moderate/high exposure cluster had reduced placental weight. Animal studies have linked prenatal poly- an...

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Veröffentlicht in:Environment international Jg. 197; S. 109308
Hauptverfasser: Khan, Sadia, Ouidir, Marion, Lemaitre, Nicolas, Jovanovic, Nicolas, Bayat, Sam, Lyon-Caen, Sarah, Hoffmann, Pascale, Desseux, Morgane, Thomsen, Cathrine, Couturier-Tarrade, A., Småstuen Haug, Line, Valmary-Degano, Séverine, Siroux, Valérie, Slama, Rémy, Alfaidy, Nadia, Philippat, Claire
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier Ltd 01.03.2025
Elsevier
Schlagworte:
Adult
Angiogenesis
animals
Bayesian theory
blood serum
calcification
cluster analysis
Endocrine disruptors
environment
Environmental Pollutants - blood
Environmental Pollutants - toxicity
Female
Fetal maternal exchanges
fibrin
Fluorocarbons - blood
Fluorocarbons - toxicity
Histology
Humans
Life Sciences
Maternal Exposure - statistics & numerical data
Mixture
Per- and Polyfluoroalkyl Substances
perfluorotridecanoic acid
Placenta - drug effects
Placenta - physiology
Placental Vascularization
Pregnancy
Young Adult
Endocrine disruptors
DOHaD
FPR
PFNA
PFAS
Mixture
6:2 diPAP
Angiogenesis
Per- and Polyfluoroalkyl Substances
PFDA
PFHxPA
PFTrDA
Fetal maternal exchanges
PFR
PFPeA
HPLC
LOD
PFDoDA
PFBS
OR
PFHxS
CI
6:2Cl-PFESA
MS
Histology
PFUnDA
PFHpA
Placental Vascularization
PFOA
LOQ
GW
BKMR
br-PFHxS
PFHpS
PFOS
ISSN:0160-4120, 1873-6750, 1873-6750
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Zusammenfassung:[Display omitted] •First study about the effects of PFAS on human placental histological parameters.•PFTrDA, PFHxPA, PFHpA, and 6:2 diPAP associated with fetal − maternal exchanges.•Women in the moderate/high exposure cluster had reduced placental weight. Animal studies have linked prenatal poly- and perfluoroalkyl substances (PFAS) exposures with impaired placental structure and function. In humans, only few studies have investigated such associations. We studied whether PFAS, individually and as a mixture, affected placental function. In 367 pregnant women, we quantified 13 PFAS in serum collected at 19.3 gestational weeks (median). Placental weight was recorded at delivery. Histological examination of placental tissues allowed estimation of vascular perfusion (percentage of villi with syncytial knots, capillary density, intervillous space) and placental aging (fibrin deposition, calcification). Associations between PFAS and each of these parameters were assessed using adjusted linear, logistic regressions and mixture modeling through cluster analysis and Bayesian kernel machine regression (BKMR). PFHxPA quantification (yes versus no) was associated with an increase in the percentages of villi with syncytial knots (β = 6.0% [95% CI: 1.1; 11]) and reduced intervillous spaces (β = 4.7% [95% CI: 0.1; 9.3]). A similar pattern was observed with PFHpA. Isolated associations were observed between PFTrDA and percentages of villi with syncytial knots (β = 8.6% [95% CI: 2.2; 15]) and 6:2diPAP and capillary density (β = −17% [95% CI: −30; −4.6]). Cluster analysis suggested that women in the moderate-to-higher PFAS exposure group had on average lower placental weight (β= −30 g [95% CI: −56; −4.3]), compared to those in the lower exposure group. Pregnancy PFAS levels were associated with placental parameters of fetal-maternal exchange, highlighting their broad physiological impacts.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0160-4120
1873-6750
1873-6750
DOI:10.1016/j.envint.2025.109308