Defining the condensate landscape of fusion oncoproteins

Fusion oncoproteins (FOs) arise from chromosomal translocations in ~17% of cancers and are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing liquid-liquid phase separation (LLPS) to form aberrant biomolecular condensates, the generality of this phenomenon is unknown. W...

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Bibliographic Details
Published in:	Nature communications Vol. 14; no. 1; pp. 6008 - 25
Main Authors:	Tripathi, Swarnendu, Shirnekhi, Hazheen K., Gorman, Scott D., Chandra, Bappaditya, Baggett, David W., Park, Cheon-Gil, Somjee, Ramiz, Lang, Benjamin, Hosseini, Seyed Mohammad Hadi, Pioso, Brittany J., Li, Yongsheng, Iacobucci, Ilaria, Gao, Qingsong, Edmonson, Michael N., Rice, Stephen V., Zhou, Xin, Bollinger, John, Mitrea, Diana M., White, Michael R., McGrail, Daniel J., Jarosz, Daniel F., Yi, S. Stephen, Babu, M. Madan, Mullighan, Charles G., Zhang, Jinghui, Sahni, Nidhi, Kriwacki, Richard W.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 28.09.2023 Nature Publishing Group Nature Portfolio
Subjects:	13/106 14/19 631/114/663/2009 631/57/2269 Biomolecular Condensates Carcinogenesis Cell signaling Cell Transformation, Neoplastic Chromosome translocations Condensates Condensation Cytoplasm Functionals Gene expression HeLa Cells Humanities and Social Sciences Humans Liquid phases Localization Machine learning multidisciplinary Oncogene Proteins, Fusion Oncoproteins Phase separation Reagents Science Science (multidisciplinary) Tumorigenesis
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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