Defining the condensate landscape of fusion oncoproteins

Fusion oncoproteins (FOs) arise from chromosomal translocations in ~17% of cancers and are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing liquid-liquid phase separation (LLPS) to form aberrant biomolecular condensates, the generality of this phenomenon is unknown. W...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Nature communications Ročník 14; číslo 1; s. 6008 - 25
Hlavní autoři:	Tripathi, Swarnendu, Shirnekhi, Hazheen K., Gorman, Scott D., Chandra, Bappaditya, Baggett, David W., Park, Cheon-Gil, Somjee, Ramiz, Lang, Benjamin, Hosseini, Seyed Mohammad Hadi, Pioso, Brittany J., Li, Yongsheng, Iacobucci, Ilaria, Gao, Qingsong, Edmonson, Michael N., Rice, Stephen V., Zhou, Xin, Bollinger, John, Mitrea, Diana M., White, Michael R., McGrail, Daniel J., Jarosz, Daniel F., Yi, S. Stephen, Babu, M. Madan, Mullighan, Charles G., Zhang, Jinghui, Sahni, Nidhi, Kriwacki, Richard W.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 28.09.2023 Nature Publishing Group Nature Portfolio
Témata:	13/106 14/19 631/114/663/2009 631/57/2269 Biomolecular Condensates Carcinogenesis Cell signaling Cell Transformation, Neoplastic Chromosome translocations Condensates Condensation Cytoplasm Functionals Gene expression HeLa Cells Humanities and Social Sciences Humans Liquid phases Localization Machine learning multidisciplinary Oncogene Proteins, Fusion Oncoproteins Phase separation Reagents Science Science (multidisciplinary) Tumorigenesis
ISSN:	2041-1723, 2041-1723
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!